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المؤلفون: Margareth C, Ozelo, Johnny, Mahlangu, K John, Pasi, Adam, Giermasz, Andrew D, Leavitt, Michael, Laffan, Emily, Symington, Doris V, Quon, Jiaan-Der, Wang, Kathelijne, Peerlinck, Steven W, Pipe, Bella, Madan, Nigel S, Key, Glenn F, Pierce, Brian, O'Mahony, Radoslaw, Kaczmarek, Joshua, Henshaw, Adebayo, Lawal, Kala, Jayaram, Mei, Huang, Xinqun, Yang, Wing Y, Wong, Benjamin, Kim, Annette, Von Drygalski
المصدر: New England Journal of Medicine. 386:1013-1025
مصطلحات موضوعية: Adult, Male, GENEr8-1 Trial Group, Factor VIII, Genetic Vectors, Alanine Transaminase, Hemorrhage, Genetic Therapy, General Medicine, Dependovirus, Hemophilia A, Intention to Treat Analysis, HIV Seronegativity, General & Internal Medicine, Humans, Infusions, Intravenous, 11 Medical and Health Sciences
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7596a3e58a0a0931c39ea2ce694c13Test
https://doi.org/10.1056/nejmoa2113708Test -
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المؤلفون: Emily Symington, Glenn F. Pierce, Adam Giermasz, K. John Pasi, Stefan Tiefenbacher, Stephen J. Zoog, Mary Robinson, Savita Rangarajan, Steffen Rosen, Christian Vettermann, Donnie Mackenzie, Jaydeep K. Srimani, Benjamin Kim, Mei Huang, Terri Christianson
المصدر: Blood. 136:2524-2534
مصطلحات موضوعية: Male, congenital, hereditary, and neonatal diseases and abnormalities, Genetic enhancement, Transgene, Immunology, 030204 cardiovascular system & hematology, Pharmacology, Hemophilia A, Biochemistry, Virus, law.invention, 03 medical and health sciences, 0302 clinical medicine, Thrombin, Parvovirinae, law, hemic and lymphatic diseases, medicine, Humans, media_common.cataloged_instance, Transgenes, European union, media_common, Factor VIII, business.industry, Genetic Therapy, Cell Biology, Hematology, Dependovirus, Coagulation, Recombinant DNA, Specific activity, business, 030215 immunology, medicine.drug
وصف الملف: text
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b54fc4a67379b3e101a905a194db2aTest
https://doi.org/10.1182/blood.2020005683Test -
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المؤلفون: Bent Winding, Keiji Nogami, Guy Young, Chris Barnes, Huixing Yuan, Johannes Oldenburg, Elena Santagostino, Liane Khoo, Beatrice Nolan, Barbara A. Konkle, Joachim Fruebis, K. John Pasi, Ingrid Pabinger, Dan Rudin, Johnny Mahlangu
المصدر: Haemophilia
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Adolescent, Recombinant Fusion Proteins, 030204 cardiovascular system & hematology, Haemophilia, Hemophilia A, Recombinant factor viii, bleed rate, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, medicine, Clinical endpoint, Humans, Clinical Haemophilia, Child, Genetics (clinical), rFVIIIFc, Aged, extended half‐life, Factor VIII, business.industry, Hematology, General Medicine, Original Articles, Bleed, Middle Aged, medicine.disease, Confidence interval, Immunoglobulin Fc Fragments, Regimen, Fc fusion, Treatment Outcome, individualized prophylaxis, Child, Preschool, Severe haemophilia A, Original Article, Female, business, perioperative haemostasis, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4022ccca7aa7b264ac7e5d898662bfTest
http://europepmc.org/articles/PMC7384031Test -
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المؤلفون: Tara M Robinson, Savita Rangarajan, K. John Pasi, Michael Laffan, Emily Symington, Will Lester, Bella Madan, Wing Yen Wong, Glenn F. Pierce, Xinqun Yang, Benjamin Kim, Nina Mitchell
المساهمون: Apollo - University of Cambridge Repository
المصدر: Haemophilia : the official journal of the World Federation of Hemophilia. 27(6)
مصطلحات موضوعية: FVIII, Male, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, IMPACT, Genetic enhancement, Haemophilia A, haemophilia A, Hemorrhage, Haemophilia, Hemophilia A, Gastroenterology, PROPHYLAXIS, Hemostatics, Quality of life, QUALITY-OF-LIFE, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Adverse effect, Genetics (clinical), Science & Technology, Factor VIII, business.industry, 1103 Clinical Sciences, ADULTS, Hematology, General Medicine, Genetic Therapy, medicine.disease, Confidence interval, Cardiovascular System & Hematology, Tolerability, Child, Preschool, haemostasis, Cohort, Quality of Life, business, Life Sciences & Biomedicine
وصف الملف: text/xml; application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c531853ba9fa59e5941dee55d492e2dTest
https://pubmed.ncbi.nlm.nih.gov/34378280Test -
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المؤلفون: Sylvia Fong, Bridget Yates, Choong-Ryoul Sihn, Aras N. Mattis, Nina Mitchell, Su Liu, Chris B. Russell, Benjamin Kim, Adebayo Lawal, Savita Rangarajan, Will Lester, Stuart Bunting, Glenn F. Pierce, K. John Pasi, Wing Yen Wong
المصدر: Nature medicine. 28(4)
مصطلحات موضوعية: Factor VIII, Genetic Vectors, Humans, General Medicine, Genetic Therapy, RNA, Messenger, Transgenes, Dependovirus, Hemophilia A, General Biochemistry, Genetics and Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ec81cb125a763b18f0efb8ec326442Test
https://pubmed.ncbi.nlm.nih.gov/35411075Test -
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المؤلفون: Cedric Hermans, Maria Elisa Mancuso, K. John Pasi, Beatrice Nolan
المساهمون: UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service d'hématologie
المصدر: European Journal of Haematology
European journal of haematology, Vol. 106, no. 6, p. 745-761 (2021)مصطلحات موضوعية: medicine.medical_specialty, immune tolerance, Recombinant Fusion Proteins, Haemophilia A, Once weekly, factor VIII‐Fc fusion protein, haemophilia A, Review Article, Haemophilia, Hemophilia A, Recombinant factor viii, 03 medical and health sciences, Therapeutic approach, 0302 clinical medicine, hemic and lymphatic diseases, half‐life, medicine, Humans, Factor VIII-Fc fusion protein, Intensive care medicine, surgical haemostasis, rFVIIIFc, Clinical Trials as Topic, Factor VIII, business.industry, Prophylaxis, Immune tolerance, Hematology, General Medicine, medicine.disease, Half-life, Immunoglobulin Fc Fragments, Fc fusion, Patient need, 030220 oncology & carcinogenesis, recombinant fusion proteins, prophylaxis, business, Dosing Frequency, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5f34e0da36f347a33816459b9017d8Test
https://pubmed.ncbi.nlm.nih.gov/33650192Test -
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المؤلفون: Chris B. Russell, Nina Mitchell, K. John Pasi, Savita Rangarajan, Wing Yen Wong, Michael Laffan, Will Lester, Bella Madan, Glenn F. Pierce, Emily Symington, Mingjin Li
مصطلحات موضوعية: Oncology, Adult, Male, LIVER TRANSDUCTION, FVIII, medicine.medical_specialty, STRESS, VIRUS VECTOR GENOMES, viruses, Genetic enhancement, Genetic Vectors, MEDLINE, Hemorrhage, 030204 cardiovascular system & hematology, Hemophilia A, Virus, PREEXISTING IMMUNITY, 03 medical and health sciences, Dependovirus, Young Adult, 0302 clinical medicine, Medicine, General & Internal, Internal medicine, General & Internal Medicine, medicine, Humans, 030212 general & internal medicine, Transgenes, Young adult, Infusions, Intravenous, 11 Medical and Health Sciences, Factor VIII, Science & Technology, business.industry, Coagulants, Follow up studies, General Medicine, Genetic Therapy, FACTOR-IX, ASSOCIATION, Middle Aged, Clinical trial, MICE, business, Life Sciences & Biomedicine, Biomarkers, Follow-Up Studies
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2fb2f488cde0f386819c674b197bcaaTest
http://hdl.handle.net/10044/1/75763Test -
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المؤلفون: Hua Yu, Michael Laffan, Liron Walsh, Savita Rangarajan, David Perry, Glenn F. Pierce, Christian Vettermann, Wing Yen Wong, K. John Pasi, Will Lester, Bella Madan
مصطلحات موضوعية: 0301 basic medicine, Serotype, Adult, Male, medicine.medical_specialty, Genetic enhancement, VARIANT, Genetic Vectors, Hemorrhage, Antibodies, Viral, Hemophilia A, Gastroenterology, THERAPY, Virus, PROPHYLAXIS, 03 medical and health sciences, Young Adult, Medicine, General & Internal, hemic and lymphatic diseases, Internal medicine, General & Internal Medicine, medicine, MANAGEMENT, Humans, RATES, Young adult, Infusions, Intravenous, 11 Medical and Health Sciences, Factor IX, Science & Technology, Factor VIII, biology, business.industry, General Medicine, FACTOR-IX, Genetic Therapy, Dependovirus, Virus Shedding, Clinical trial, MICE, 030104 developmental biology, Cohort, DNA, Viral, biology.protein, TRIAL, Antibody, business, Life Sciences & Biomedicine, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4024b00e18bbd0f716af1b6f423e6c1dTest
http://hdl.handle.net/10044/1/57163Test -
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المؤلفون: Glenn F. Pierce, Guy Young, Johnny Mahlangu, Lynda M. Cristiano, Chris Barnes, Roshni Kulkarni, Beatrice Nolan, John Pasi, G. Allen, Srividya Neelakantan, Giulia Gambino, R. Liesner
المصدر: Journal of Thrombosis and Haemostasis. 13:967-977
مصطلحات موضوعية: Male, China, Pediatrics, medicine.medical_specialty, Recombinant Fusion Proteins, Population, Hemophilia A, Severity of Illness Index, Drug Administration Schedule, South Africa, Pharmacokinetics, Risk Factors, Internal medicine, Hemarthrosis, Severity of illness, Clinical endpoint, Humans, Medicine, Child, Infusions, Intravenous, education, Adverse effect, education.field_of_study, Factor VIII, Coagulants, business.industry, Age Factors, Australia, Hematology, Bleed, medicine.disease, Antibodies, Neutralizing, Immunoglobulin Fc Fragments, Europe, Regimen, Treatment Outcome, Child, Preschool, North America, Female, business, Half-Life
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6426bd1f0ecc2973f52f4530a7c57fTest
https://doi.org/10.1111/jth.12911Test -
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المؤلفون: Johnny, Mahlangu, Jerry S, Powell, Margaret V, Ragni, Pratima, Chowdary, Neil C, Josephson, Ingrid, Pabinger, Hideji, Hanabusa, Naresh, Gupta, Roshni, Kulkarni, Patrick, Fogarty, David, Perry, Amy, Shapiro, K John, Pasi, Shashikant, Apte, Ivan, Nestorov, Haiyan, Jiang, Shuanglian, Li, Srividya, Neelakantan, Lynda M, Cristiano, Jaya, Goyal, Jurg M, Sommer, Jennifer A, Dumont, Nigel, Dodd, Karen, Nugent, Gloria, Vigliani, Alvin, Luk, Aoife, Brennan, Glenn F, Pierce, Michael, Guerrera
المصدر: Blood. 123:317-325
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Time Factors, Adolescent, Recombinant Fusion Proteins, Immunology, Population, Phases of clinical research, Hemorrhage, Hemophilia A, Biochemistry, Gastroenterology, Drug Administration Schedule, law.invention, Young Adult, Pharmacokinetics, Randomized controlled trial, law, Internal medicine, medicine, Humans, Child, education, Adverse effect, Aged, Emicizumab, education.field_of_study, Factor VIII, business.industry, Cell Biology, Hematology, Perioperative, Middle Aged, Immunoglobulin Fc Fragments, Surgery, Clinical trial, Treatment Outcome, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ad06452fa42ce883fe6419d169422eTest
https://doi.org/10.1182/blood-2013-10-529974Test