المؤلفون: Chehaibou, Ismael, Manoharan, Niranjan, Govetto, Andrea, Tsui, Irena, Hubschman, Jean-Pierre

المصدر: Retinal cases & brief reports, vol 16, iss 4

مصطلحات موضوعية: genetic structures, Visual Acuity, Epiretinal Membrane, Neurodegenerative, Retinal Perforations, Eye, eye diseases, Macular Degeneration, Optical Coherence, Clinical Research, Opthalmology and Optometry, Vitrectomy, Humans, sense organs, Tomography, Eye Disease and Disorders of Vision, Retrospective Studies, Follow-Up Studies

الوصف: PurposeTo report two cases of spontaneous closure of lamellar macular holes with epiretinal proliferation (ERP).MethodsObservational cases report.ResultsTwo patients affected with lamellar macular hole showed progressive and spontaneous closure of the hole associated with ERP development. At presentation, both patients presented with irregular foveal contour, and foveal cavitation with apparent loss of retinal tissue. In both cases, ERP, also called "lamellar hole-associated epiretinal proliferation", was present and increased in size over time. This proliferation progressively developed across the hole with apparent restoration of the foveal contour and preservation of visual acuity.ConclusionThis report describes two cases of lamellar macular hole in which ERP increased over time, resulting in lamellar macular hole closure. Such observations may suggest a spontaneous healing process driven by glial cell proliferation.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f02daa6491f45ceb6490016d85c1dc45Test
https://escholarship.org/uc/item/95w9x931Test

المؤلفون: Hubschman, Jean-Pierre, Govetto, Andrea, Spaide, Richard, Schumann, RG, Steel, David H, Figueroa, Marta, Sebag, J, Gaudric, Alain, Staurenghi, Giovanni, Haritoglou, Christos, Kazuaki, Kadonosono, Thompson, John, Chang, Stanley, Bottoni, Ferdinando, Tadayoni, Ramin

مصطلحات موضوعية: genetic structures, Opthalmology and Optometry, Macula, Clinical Sciences, Public Health and Health Services, sense organs, Ophthalmology & Optometry, eye diseases, Retina

الوصف: Background: A consensus on an optical coherence tomography (OCT) definition of lamellar macular hole (LMH) and similar conditions is needed. Methods: The panel reviewed relevant peer-reviewed literature to reach a consensus on LMH definition and to differentiate LMH from other similar conditions. Results: The panel reached a consensus on the definition of 3 clinical entities: LMH, epiretinal membrane (ERM) foveoschisis and macular pseudohole (MPH). LMH definition is based on 3 mandatory criteria and 3 optional anatomical features. The 3 mandatory criteria are the presence of irregular foveal contour, the presence of a foveal cavity with undermined edges, and the apparent loss of foveal tissue. Optional anatomical features include the presence of epiretinal proliferation, the presence of a foveal bump and the disruption of the ellipsoid line. ERM foveoschisis definition is based on 2 mandatory criteria: the presence of ERM and the presence of schisis at the level of Henle’s fiber layer. Three optional anatomical features can also be present: the presence of microcystoid spaces in the inner nuclear layer (INL), an increase of retinal thickness, and the presence of retinal wrinkling. MPH definition is based on 3 mandatory criteria and 2 optional anatomical features. Mandatory criteria include the presence of a foveal sparing ERM, the presence of a steepened foveal profile and an increased central retinal thickness. Optional anatomical features are the presence of microcystoid spaces in the INL and a normal retinal thickness. Conclusions: The use of the proposed definitions may provide uniform language for clinicians and future research.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______325::727f73e5f20cc889718d61b29d38f780Test
https://escholarship.org/uc/item/5gn9s3c4Test

المؤلفون: dell’Omo, Roberto, Filippelli, Mariaelena, De Turris, Serena, Govetto, Andrea, Napolitano, Pasquale, Ermanno dell’Omo, Costagliola, Ciro

المصدر: Journal of Ophthalmology.

مصطلحات موضوعية: genetic structures, Article Subject, sense organs, eye diseases

الوصف: Evolution of imaging techniques has renewed interest in the diagnosis of lamellar macular hole (LMH) and greatly implemented the possibilities of gaining more detailed insights into its pathogenesis. Among noninvasive techniques, optical coherence tomography (OCT) is considered the primary examination modality to study LMHs, given its ability to image foveal structure and its widespread availability. OCT also allows to resolve the epiretinal materials associated with LMH, i.e., tractional epiretinal membranes (ERMs) and epiretinal proliferation (EP). En face OCT reconstructions are useful to confirm the foveal abnormalities shown by the eyes with LMH, whereas OCT angiography may reveal alterations of the size and shape of the foveal avascular zone and alterations of the density of the superficial and deep vascular plexuses. On slit-lamp biomicroscopy or fundus camera examination, LMH appears as a round or oval, reddish lesion at the center of the macula, slightly darker than the surrounding retina. The associated tractional ERM, causing wrinkling and glistening of the retinal surface, is usually readily appreciable, whereas EP is hardly apparent on biomicroscopy or fundus photography since the retina surface appears smooth. When imaged with blue fundus autofluorescence (B-FAF) imaging, LMHs are characterized by an increased autofluorescent signal, the intensity of which does not correlate with the thickness of the residual outer retinal tissue. Green reflectance and blue reflectance (BR) images clearly show the increased reflection and wrinkling of the retinal surface caused by tractional ERM associated with LMH. BR and multicolor imaging enable the visualization of EP associated with LMH in the form of a sharply demarcated dark area and in the form of a yellowish area surrounding the hole, respectively. Scarce data regarding invasive imaging techniques, such as fluorescein angiography, for the study of LMH are available in the literature. The aim of this review is to evaluate the contribution that each imaging modality can provide to study the morphologic characteristics of LMH.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=hindawi_publ::69ce1f5e63b642aff1be34d34b1dcd8fTest

المؤلفون: Chen, Cheng-Wei, Francone, Anibal Andrés, Gerber, Matthew J, Lee, Yu-Hsiu, Govetto, Andrea, Tsao, Tsu-Chin, Hubschman, Jean-Pierre

المصدر: Journal of cataract and refractive surgery, vol 45, iss 11

مصطلحات موضوعية: Phacoemulsification, genetic structures, Crystalline, Swine, Animal, Operative Time, Clinical Sciences, Ophthalmology & Optometry, eye diseases, Capsulorhexis, Lens, Computer-Assisted, Robotic Surgical Procedures, Optical Coherence, Models, Opthalmology and Optometry, Animals, Surgery, sense organs, Intraoperative Complications, Tomography

الوصف: PurposeTo evaluate semiautomated surgical lens extraction procedures using the optical coherence tomography (OCT)-integrated Intraocular Robotic Interventional Surgical System.SettingStein Eye Institute and Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, USA.DesignExperimental study.MethodsSemiautomated lens extraction was performed on postmortem pig eyes using a robotic platform integrated with an OCT imaging system. Lens extraction was performed using a series of automated steps including robot-to-eye alignment, irrigation/aspiration (I/A) handpiece insertion, anatomic modeling, surgical path planning, and I/A handpiece navigation. Intraoperative surgical supervision and human intervention were enabled by real-time OCT image feedback to the surgeon via a graphical user interface. Manual preparation of the pig-eye models, including the corneal incision and capsulorhexis, was performed by a trained cataract surgeon before the semiautomated lens extraction procedures. A scoring system was used to assess surgical complications in a postoperative evaluation.ResultsComplete lens extraction was achieved in 25 of 30 eyes. In the remaining 5 eyes, small lens pieces (≤1.0mm3) were detected near the lens equator, where transpupillary OCT could not image. No posterior capsule rupture or corneal leakage occurred. The mean surgical duration was 277seconds±42 (SD). Based on a 3-point scale (0=no damage), damage to the iris was 0.33±0.20, damage to the cornea was 1.47±0.20 (due to tissue dehydration), and stress at the incision was 0.97±0.11.ConclusionsNo posterior capsule rupture was reported. Complete lens removal was achieved in 25 trials without significant surgical complications. Refinements to the procedures are required before fully automated lens extraction can be realized.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od_______325::42ab60d8e18fb1a573378cdbc206f70cTest
https://escholarship.org/uc/item/8795c97sTest

المؤلفون: Chen, Cheng-Wei, Lee, Yu-Hsiu, Gerber, Matthew J, Cheng, Harrison, Yang, Yan-Chao, Govetto, Andrea, Francone, Anibal Andrés, Soatto, Stefano, Grundfest, Warren S, Hubschman, Jean-Pierre, Tsao, Tsu-Chin

المساهمون: Clive, Loughlin

المصدر: The international journal of medical robotics + computer assisted surgery : MRCAS, vol 14, iss 6

مصطلحات موضوعية: cataract extraction, Aging, genetic structures, Swine, automated cataract surgery, Clinical Sciences, intraocular surgery, Bioengineering, Equipment Design, OCT-guided surgery, eye diseases, Cataract, Automation, Robotic Surgical Procedures, Optical Coherence, robotic surgery, Biomedical Imaging, Animals, Humans, Surgery, sense organs, robot-assisted ophthalmic surgery, Eye Disease and Disorders of Vision, Tomography, Software

الوصف: BackgroundWith the development of laser-assisted platforms, the outcomes of cataract surgery have been improved by automating several procedures. The cataract-extraction step continues to be manually performed, but due to deficiencies in sensing capabilities, surgical complications such as posterior capsule rupture and incomplete cataract removal remain.MethodsAn optical coherence tomography (OCT) system is integrated into our intraocular robotic interventional surgical system (IRISS) robot. The OCT images are used for preoperative planning and intraoperative intervention in a series of automated procedures. Real-time intervention allows surgeons to evaluate the progress and override the operation.ResultsThe developed system was validated by performing lens extraction on 30 postmortem pig eyes. Complete lens extraction was achieved on 25 eyes, and "almost complete" extraction was achieved on the remainder due to an inability to image small lens particles behind the iris. No capsule rupture was found.ConclusionThe IRISS successfully demonstrated semiautomated OCT-guided lens removal with real-time supervision and intervention.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3508244c23e21d9e7e38c3c7c984100aTest
https://escholarship.org/uc/item/8km2n4tbTest

المؤلفون: Preti, Rony C, Govetto, Andrea, Filho, Richard Geraldo Aqueta, Cabral Zacharias, Leandro, Gianotti Pimentel, Sergio, Takahashi, Walter Y, Monteiro, Mario LR, Hubschman, Jean Pierre, Sarraf, David

المصدر: Retina (Philadelphia, Pa.), vol 38, iss 8

مصطلحات موضوعية: Male, genetic structures, Retinal Degeneration, Visual Acuity, microcystic macular changes, Retinal Pigment Epithelium, Middle Aged, Retinal Photoreceptor Cell Outer Segment, Ophthalmology & Optometry, choroidal neovascularization, eye diseases, spectral domain optical coherence tomography, Muller cells, Optical Coherence, outer retinal tubulations, Opthalmology and Optometry, Geographic Atrophy, 80 and over, Humans, Female, sense organs, Tomography, Retrospective Studies, Aged

الوصف: PurposeTo describe the sequential evolution of outer retinal tubulations (ORTs) in patients diagnosed with choroidal neovascularization and/or retinal pigment epithelium atrophy.MethodsRetrospective evaluation of spectral domain optical coherence tomography of a consecutive cohort of patients with various retinal conditions.ResultsWe reviewed the clinical findings of 238 eyes of 119 consecutive patients (54 men and 65 women) with a mean age of 76.2 ± 14.2 years (range: 57-90) and a mean follow-up of 3 ± 1.6 years (range 1-7). Over the follow-up period, ORTs were diagnosed in 67 of 238 eyes (28.1%), 9 of which were imaged with sequential, eye-tracked spectral domain optical coherence tomography dating from the beginning of ORT formation. The presence of geographic atrophy and subretinal hyperreflective material at baseline were found to be risk factors for ORT development (P < 0.001 and P < 0.001, respectively). Outer retinal tubulations were divided into forming versus formed morphologies. The latter was comprised open and closed ORTs of which the open subtype was the most common. The formation of ORTs was significantly associated with microcystic macular lesions in the inner nuclear layer and the downward displacement of the outer plexiform layer, referred to as the outer plexiform layer subsidence sign (P < 0.001).ConclusionOuter retinal tubulation is a frequent optical coherence tomography finding in eyes with choroidal neovascularization and geographic atrophy. Open ORTs with progressive scrolled edges and shortened diameter were significantly associated with microcystic macular lesions in the inner nuclear layer and the outer plexiform layer subsidence sign.

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https://escholarship.org/uc/item/17v734z0Test

المؤلفون: Ferrara, M., Romano, V., Steel, D. H., Gupta, R., Iovino, C., van Dijk, E. H. C., Rocha-de-Lossada, C., Bali, E., Valldeperas, X., Romano, D., Gadhvi, K. A., Matarazzo, F., Tzamalis, A., Grassi, P., Rachwani, R., Coco, G., Reyes-Delfino, C. D., Amoroso, F., Nakhoul, N., Sabatino, F., Shaikh, S., Au, A., Di Carlo, E., Steger, B., Govetto, A., Toro, M., Cennamo, M., Demirel, S., Napolitano, P., Cartes, C., Raimondi, R., Montericcio, A., Dell'Aversanaorabona, G., Comune, C., Borroni, D., Pagano, L., Montalbano, C., Iannetta, D., Angi, M., Romano, M. R.

المساهمون: Ferrara, M., Romano, V., Steel, D. H., Gupta, R., Iovino, C., van Dijk, E. H. C., Rocha-de-Lossada, C., Bali, E., Valldeperas, X., Romano, D., Gadhvi, K. A., Matarazzo, F., Tzamalis, A., Grassi, P., Rachwani, R., Coco, G., Reyes-Delfino, C. D., Amoroso, F., Nakhoul, N., Sabatino, F., Shaikh, S., Au, A., Di Carlo, E., Steger, B., Govetto, A., Toro, M., Cennamo, M., Demirel, S., Napolitano, P., Cartes, C., Raimondi, R., Montericcio, A., Dell'Aversanaorabona, G., Comune, C., Borroni, D., Pagano, L., Montalbano, C., Iannetta, D., Angi, M., Romano, M. R., Ferrara, Mariantonia, Romano, Vito, H Steel, Davi, Gupta, Rajen, Iovino, Claudio, van Dijk, Elon H. C., Rocha-de-Lossada, Carlo, Bali, Ernesto, Valldeperas, Xavier, Romano, Davide, Gadhvi, Kunal A., Matarazzo, Francesco, Tzamalis, Argyrio, Grassi, Piergiacomo, Rachwani, Rahul, Coco, Giulia, Dianne Reyes-Delfino, Catherine, Amoroso, Francesca, Nakhoul, Nakhoul, Sabatino, Francesco, Shaikh, Sufiyan, Au, Adrian, Di Carlo, Emiliano, Steger, Bernhard, Govetto, Andrea, Toro, mario damiano, Cennamo, Michela, Demirel, Sibel, Napolitano, Pasquale, Cartes, Cristian, Raimondi, Raffaele, Montericcio, Alessio, Dell’Aversana Orabona, Giancarlo, Comune, Chiara, Borroni, Davide, Pagano, Luca, Montalbano, Clara, Iannetta, Danilo, Angi, Martina, Romano, Mario

المصدر: EYE
Eye
Eye, 34(11), 2089-2097. SPRINGERNATURE

مصطلحات موضوعية: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Eye Diseases, Pneumonia, Viral, Events, education, MEDLINE, Comorbidity, Training (civil), Article, Education, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Medical research, Ophthalmology, Settore MED/30, Surveys and Questionnaires, Pandemic, Correspondence, medicine, Surveys and Questionnaire, Humans, Curriculum, Pandemics, Descriptive statistics, Betacoronaviru, business.industry, Coronavirus Infection, SARS-CoV-2, Internship and Residency, COVID-19, Eye Disease, medicine.disease, Surgical training, Health services, Education, Medical, Graduate, 030221 ophthalmology & optometry, business, Coronavirus Infections, 030217 neurology & neurosurgery, Human

الوصف: Background: The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on practical activities and didactic teaching of residents and fellows. This survey aimed to propose long-term changes for ophthalmology training based on the changes experienced by trainees and their perception of new training opportunities. Methods: An online survey was distributed to ophthalmology trainees in multiple countries. Descriptive statistics were used to analyse the data. Results: A total of 504 analyzable responses were collected from 32 different countries. The current impact of COVID-19 pandemic was described as “severe” by most trainees (55.2%); however, the future perspective was more optimistic as demonstrated by the greater number of responses reporting a presumed “moderate” (37.3%), “mild” (14.1%) or “slight” (4.2%) long-term impact. The vast majority of trainees reported a decrease ≥50% of clinical activity (76.4%) and >75% of surgical activity (74.6%). Although an initial gap in didactic teaching has been experienced by many (55.4%), regular web-based teaching was reportedly attended by 67.7% of the respondents. A strong agreement was found regarding the worthwhile role of web-based case-presentations in clinical training (91.7%), web-based discussion of edited surgical videos (85.7%) and simulation-based practice (86.9%) in surgical training. Conclusions: This survey, focusing on trainees’ perspective, strongly reinforces the need to promptly include new technology-based training tools, such as web-based teaching, virtual surgical simulators, and telementoring, in long-term reorganisation of ophthalmology training to ensure its continuity and effectiveness, which would remain available even in the face of another unpredictable crisis within the health system.

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الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9131cc4f3acbd375102e48815d4908dTest
https://hdl.handle.net/1887/3182877Test