التفاصيل البيبلوغرافية
العنوان:
Comprehensive molecular portraits of human breast tumours
المؤلفون:
Julie M. Gastier-Foster , Nguyen Van Bang , Christopher Szeto , Daoud Meerzaman , Nguyen Viet Tien , Richard K. Wilson , Jennifer Brown , Singer Ma , Andrew H. Beck , Sam Ng , Phillip H. Lai , Peter J. Park , Khurram Z. Khan , Gordon B. Mills , Joel S. Parker , Li Ding , Ying Hu , Jill P. Mesirov , Rebecca Carlsen , Kevin P. White , Benjamin P. Berman , Michael C. Adams , Laura A.L. Dillon , Jake Lin , Giovanni Ciriello , Simeen Malik , Moiz S. Bootwalla , Sheila Reynolds , Petar Stojanov , B. Arman Aksoy , Jerry Usary , Mei Huang , Andrzej Mackiewicz , Prachi Kothiyal , Keith A. Baggerly , Hann Hsiang Chao , Timo Erkkilä , Elaine R. Mardis , Nils Gehlenborg , Bradley M. Broom , Tara M. Lichtenberg , Jeff Gentry , Payal Sipahimalani , Chris Wakefield , Zhining Wang , Anna Chu , Konstanty Korski , Michael S. Noble , Lawrence A. Donehower , Pavana Anur , Janita Thusberg , Rohit Bhargava , Chris Sander , Lori Boice , Juok Cho , Charles Saller , Sophie C. Egea , Marc Danie Nazaire , Heather Schmidt , Bui Duc Phu , Hye Jung E. Chun , Bradley A. Ozenberger , Robert S. Fulton , Carrie Hirst , Stephen B. Baylin , Miruna Balasundaram , Peter White , Fergus J. Couch , Saianand Balu , Christina Yau , Yevgeniy Antipin , Jacek J. Brzeziński , Rehan Akbani , Todd Pihl , Ari B. Kahn , Nianxiang Zhang , Sean P. Barletta , Mary Iacocca , Kelly Daily , Wiam Bshara , Marc Ladanyi , Michael D. Topal , Huy Nguyen , Theodore C. Goldstein , Tari A. King , Bernard Kohl , Jingchun Zhu , Wiktoria Maria Suchorska , Xuan Van Le , Wei Zhang , Yan Shi , Marta Bogusz-Czerniewicz , Barry S. Taylor , Li-Wei Chang , Matthew C. Nicholls , Julien Baboud , Honorata Tatka , Doug Voet , Vesteinn Thorsson , Richard W. Park , Aaron D. Black , Pawel Murawa , Leonid Kvecher , Raju Kucherlapati , Colleen Mitchell , Wei Zhao , Leigh B. Thorne , Artem Sokolov , Modesto Patangan , Yidi J. Turman , Teresa R. Tabler , Kyle Ellrott , Yaron S.N. Butterfield , Gordon Saksena , Ronglai Shen , Yaqin Chen , Olga Voronina , Candace Carter , Yiling Lu , Cynthia McAllister , Thomas Stricker , Chunqing Luo , Dominique L. Berton , Thomas Barr , Robert A. Holt , Christopher Wilks , David Van Den Berg , Robert Sfeir , Ilya Shmulevich , Ranabir Guin , Nilsa C. Ramirez , Hollie A. Harper , John A. Demchok , Matthew J. Ellis , David Haussler , Katherine A. Hoadley , Eric Chuah , Richard J. Mural , Charles M. Perou , Timothy J. Triche , Steven J.M. Jones , Mark A. Jensen , Jeffrey R. Marks , Hanna Perz , Rashmi N. Sanbhadti , Robin J.N. Coope , Brian Craft , Andy Chu , Peter W. Laird , Eric E. Snyder , Chunhua Yan , Martin L. Ferguson , Junyuan Wu , Richard Varhol , Daniel J. Weisenberger , Yongjun Zhao , Ewa Leporowska , Ashley Hill , Katie Tarvin , M. Teresiak , David Pot , Nguyen Phi Hung , Helga Thorvaldsdottir , Erik Zmuda , Spring Yingchun Liu , Melissa Hart-Kothari , Joshua M. Stuart , Caroline Larson , Erin Pleasance , Nikolaus Schultz , Matthew Ibbs , Hubert Stoppler , Joelle Kalicki-Veizer , Andrey Sivachenko , Christopher C. Benz , Dawid Murawa , Swapna Mahurkar , Nicholas J. Petrelli , Lynda Chin , Juinhua Zhang , Pei Lin , Michael Mayo , Wilma L. Lingle , Julian Malicki , Robin Brookens , Ethan Cerami , Angela Tam , Shelley Alonso , Carmelo Gaudioso , Dominik Stoll , Anders Jacobsen , Stephen C. Benz , Mark S. Guyer , Wendy Winckler , Roel R.G. Verhaak , Chang-Jiun Wu , Raktim Sinha , Xiaping He , Nina Thiessen , Craig D. Shriver , Kenna R. Mills Shaw , Heidi J. Sofia , Martin Hirst , Stuart R. Jefferys , Robert Penny , Adam Brufsky , Kristen M. Leraas , Joshua F. McMichael , Brenda Rabeno , Inanc Birol , David J. Dooling , Peggy Yena , Richard A. Moore , Andrew D. Cherniack , Lucinda Fulton , Jessica K. Booker , Lihua Zou , Rileen Sinha , Michael D. Iglesia , Dennis T. Maglinte , Rohini Raman , Evan O. Paull , Rameen Beroukhim , Oleg Dolzhansky , Grace O. Silva , Jiashan Zhang , Witold Kycler , Janae V. Simons , Anisha Gulabani , Michael S. Lawrence , Peter Fielding , Huynh Quyet Thang , Peter A. Kigonya , Myra M. George , Jay Bowen , Haiyan I. Li , Robert E. Pyatt , Margi Sheth , Stacey Gabriel , Ana M. Gonzalez-Angulo , Hui Shen , Andrew J. Mungall , Carmen Gomez-Fernandez , Liming Yang , Hai Hu , Radoslaw Łaźniak , Olufunmilayo I. Olopade , Christine Czerwinski , Richard A. Hajek , Michael D. McLellan , Arash Shafiei , Matthew Meyerson , Gad Getz , Stanley Girshik , Cheng Fan , Shuying Liu , Olga Potapova , Alan P. Hoyle , Mia Grifford , Daniel C. Koboldt , Jacqueline D. Palchik , Jessica Walton , Greg Eley , Jamie Leigh Campbell , Thomas Zeng , Mikhail Abramov , Benjamin Gross , Brenda Deyarmin , Maciej Wiznerowicz , Natasja Wye , Ron Bose , Darlene Lee , Carl Morrison , Albert J. Kovatich , Andrew Crenshaw , Jessica Frick , John N. Weinstein , Adrian Ally , Nam H. Pho , Brady Bernard , Scott L. Carter , Gary K. Scott , Steven E. Schumacher , Barbara Tabak , D. Neil Hayes , Robert C. Onofrio , Sean D. Mooney , Mary D. Dyer , Mark Gerken , Erin Curley , Rajiv Dhir , Anna K. Unruh , Noreen Dhalla , Candace Shelton , Kevin R. Coombes , Richard Thorp , George E. Sandusky , A. Gordon Robertson , Marco A. Marra , Roy Tarnuzzer , Mark Backus , Aleix Prat , Kristin G. Ardlie , Daniel Di Cara , Richard Kreisberg , Kenneth H. Buetow , Jacqueline E. Schein , J. Todd Auman , Jianjiong Gao , Lisa Wise , Ling Li , James A. Robinson , Jonathan S. Berg , Tod D. Casasent , James N. Ingle , Brenda Ayala , Xiaolong Meng , Boris Reva , Rui Jing , Mark D. Pegram , Arkadiusz Spychała , Joan Pontius , Jeffrey A. Hooke , Daniel E. Carlin , Nils Weinhold , Jared R. Slobodan , Tom Bodenheimer , Wenbin Liu , Christopher K. Wong , W. Kimryn Rathmell , David Mallery , Paul T. Spellman , Hailei Zhang , Ryan Bressler , Deepak Srinivasan , Lisle E. Mose , Bryan Hernandez , Stella Somiari , Chad J. Creighton , Howard H. Sussman , Frederic Waldman , Matthew G. Soloway
المساهمون:
Universitat de Barcelona
المصدر:
Recercat. Dipósit de la Recerca de Catalunya
بيانات النشر:
Nature Publishing Group
مصطلحات موضوعية:
Proteomics , Oncologia , DNA Mutational Analysis , Genes, BRCA1 , Retinoblastoma Protein , Phosphatidylinositol 3-Kinases , 0302 clinical medicine , Breast cancer , Exome , RNA, Neoplasm , Exome sequencing , Oligonucleotide Array Sequence Analysis , Ovarian Neoplasms , Genetics , 0303 health sciences , Multidisciplinary , Triple Negative Breast Neoplasms , Genomics , 3. Good health , Gene Expression Regulation, Neoplastic , Receptors, Estrogen , Oncology , 030220 oncology & carcinogenesis , Female , DNA Copy Number Variations , Class I Phosphatidylinositol 3-Kinases , Protein Array Analysis , MAP Kinase Kinase Kinase 1 , Breast Neoplasms , GATA3 Transcription Factor , Biology , Article , Càncer de mama , Genetic Heterogeneity , 03 medical and health sciences , medicine , Humans , RNA, Messenger , 030304 developmental biology , MicroRNA sequencing , Genome, Human , Genetic heterogeneity , Gene Expression Profiling , Cancer , DNA Methylation , Genes, erbB-2 , Genes, p53 , medicine.disease , Claudin-Low , Expressió gènica , MicroRNAs , Genòmica , Mutation , Gene expression , Genes, Neoplasm
الوصف:
We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays. Our ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers; however, there were numerous subtype-associated and novel gene mutations including the enrichment of specific mutations in GATA3, PIK3CA and MAP3K1 with the luminal A subtype. We identified two novel protein-expression-defined subgroups, possibly produced by stromal/microenvironmental elements, and integrated analyses identified specific signalling pathways dominant in each molecular subtype including a HER2/phosphorylated HER2/EGFR/phosphorylated EGFR signature within the HER2-enriched expression subtype. Comparison of basal-like breast tumours with high-grade serous ovarian tumours showed many molecular commonalities, indicating a related aetiology and similar therapeutic opportunities. The biological finding of the four main breast cancer subtypes caused by different subsets of genetic and epigenetic abnormalities raises the hypothesis that much of the clinically observable plasticity and heterogeneity occurs within, and not across, these major biological subtypes of breast cancer.
وصف الملف:
application/pdf
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e58d43cc0d78eda47ebd0dacd8a688Test http://hdl.handle.net/2445/101754Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....53e58d43cc0d78eda47ebd0dacd8a688
قاعدة البيانات:
OpenAIRE
