دورية أكاديمية
The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses
| العنوان: | The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses |
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| المؤلفون: | Liangshun You, Liping Mao, Juying Wei, Shenhe Jin, Chunmei Yang, Hui Liu, Li Zhu, Wenbin Qian |
| المصدر: | Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-9 (2017) |
| بيانات النشر: | BMC, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Autophagy, Endosome, Exosomes, Immune, MHC presentation, Cancer, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract T cells recognize antigen fragments from proteolytic products that are presented to them in the form of peptides on major histocompatibility complex (MHC) molecules, which is crucial for the T cell to identify infected or transformed cells. Autophagy, a process that delivers cytoplasmic constituents for lysosomal degradation, has been observed to provide a substantial source of intra- and extracellular antigens for MHC presentation to T cells, which will impact the tumor-specific immune response. Meanwhile, extracellular components are transported to cytoplasm for the degradation/secretion process by the endo-/exosomal pathway and are thus involved in multiple physiological and pathological processes, including immune responses. Autophagy and endo-/exosomal pathways are intertwined in a highly intricate manner and both are closely involved in antigen processing for MHC presentation; thus, we propose that they may coordinate in antigen processing and presentation in anticancer T cell immune responses. In this article, we discuss the molecular and functional crosstalk between autophagy and endo-/exosomal pathways and their contributions to antigen processing for MHC presentation in anticancer T cell immune responses. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-8722 |
| العلاقة: | http://link.springer.com/article/10.1186/s13045-017-0534-8Test; https://doaj.org/toc/1756-8722Test |
| DOI: | 10.1186/s13045-017-0534-8 |
| الوصول الحر: | https://doaj.org/article/92ab6a3b2d304440a2e488ae3caed998Test |
| رقم الانضمام: | edsdoj.92ab6a3b2d304440a2e488ae3caed998 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17568722 |
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| DOI: | 10.1186/s13045-017-0534-8 |