التفاصيل البيبلوغرافية
| العنوان: |
Exosomal microRNAs and exosomal long non-coding RNAs in gynecologic cancers. |
| المؤلفون: |
Hashemipour, Maryam1 (AUTHOR), Boroumand, Homa1 (AUTHOR), Mollazadeh, Samaneh1,2 (AUTHOR), Tajiknia, Vida3 (AUTHOR), Nourollahzadeh, Zahra4 (AUTHOR), Rohani Borj, Mina5 (AUTHOR), Pourghadamyari, Hossein6 (AUTHOR), Rahimian, Neda1,7 (AUTHOR) rahimian.n@iums.ac.ir, Hamblin, Michael R.1,8 (AUTHOR) hamblin.lab@gmail.com, Mirzaei, Hamed1,9 (AUTHOR) h.mirzaei2002@gmail.com |
| المصدر: |
Gynecologic Oncology. Apr2021, Vol. 161 Issue 1, p314-327. 14p. |
| مصطلحات موضوعية: |
*LINCRNA, *GYNECOLOGIC cancer, *NON-coding RNA, *MICRORNA, *GENOMIC imprinting |
| مستخلص: |
Gynecologic cancer is a group of any malignancies affecting reproductive tissues and organs of women, including ovaries, uterine, cervix, vagina, vulva, and endometrium. Several types of molecular mechanisms are associated with the progression of gynecologic cancers. Among it can be referred to the most widely studied non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs) and long ncRNAs (lncRNAs). As yet, lncRNAs are known to serve key biological roles via various mechanisms, such as splicing regulation, chromatin rearrangement, translation regulation, cell-cycle control, genetic imprinting and mRNA decay. Besides, miRNAs govern gene expression by modulation of mRNAs and lncRNAs degradation, suggestive of needing more research in this field. Generally, driving gynecological cancers pathways by miRNAs and lncRNAs lead to the current improvement in cancer-related technologies. Exosomes are extracellular microvesicles which can carry cargo molecules among cells. In recent years, more studies have been focused on exosomal non-coding RNAs (exo -ncRNAs) and exosomal microRNAs (exo-miRs) because of being natural carriers of lnc RNAs and microRNAs via programmed process. In this review we summarized recent reports concerning the function of exosomal microRNAs and exosomal long non-coding RNAs in gynecological cancers. [Display omitted] • Gynecologic cancers are one of the main health concerns of women throughout the world. • miRNAs and LncRNAs have been identified as important ncRNAs in gynecologic cancers. • Exosomes participate in signaling pathways based on ncRNAs, and can transfer different ncRNAs. • Exosomal miRNAs and exosomal lncRNAs have critical roles in gynecological cancers. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
