دورية أكاديمية
Impact of global hemodynamic load on exercise capacity in aortic stenosis.
| العنوان: | Impact of global hemodynamic load on exercise capacity in aortic stenosis. |
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| المؤلفون: | DULGHERU, Raluca Elena, Magne, Julien, Capoulade, R., DAVIN, Laurent, Vinereanu, D., Pierard, Luc, Pibarot, P., LANCELLOTTI, Patrizio |
| المصدر: | International Journal of Cardiology, 168 (3), 2272-7 (2013) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2013 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Aged, Aortic Valve Stenosis/diagnosis/physiopathology, Diastole, Echocardiography, Exercise Test, Exercise Tolerance, Female, Follow-Up Studies, Heart Ventricles/physiopathology/ultrasonography, Hemodynamics/physiology, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Severity of Illness Index, Systole, Ventricular Function, Left, Aortic stenosis, Cardiopulmonary test, Functional capacity, Valve, Valvulo-arterial impedance, Human health sciences, Cardiovascular & respiratory systems, Sciences de la santé humaine, Systèmes cardiovasculaire & respiratoire |
| الوصف: | peer reviewed ; BACKGROUND: The determinants of maximal exercise capacity (MEC) in aortic stenosis (AS) are, in large part, unknown. We hypothesized that the left ventricular (LV) global hemodynamic load--as assessed by the valvulo-arterial impedance (Zva)--is one of the main determinants of MEC and we sought to evaluate the factors associated with reduced MEC in AS. METHOD AND RESULTS: Asymptomatic patients with moderate or severe AS (n=62, aortic valve area <1.5 cm(2), 65 +/- 13 years, 68% men) and preserved LV systolic function (ejection fraction>50%) were prospectively referred for comprehensive resting echocardiography and cardiopulmonary exercise test. Absolute peak VO2 was 19.5 +/- 5.7 mL/kg/min (median 19.6 mL/kg/min; range 7.2-33.1 mL/kg/min). There were significant correlations between peak VO2 and: age, body mass index, LV stroke volumes, cardiac output, mean flow rate, mitral annulus s' and e' wave velocities, E/e' ratio and left atrial diameter (all p<0.05). Indexed mean flow rate and Zva were the strongest univariable echocardiographic determinants of peak VO2 (r=0.44, p<0.001 and r=-0.39, p=0.002, respectively). In addition, patients with reduced MEC (peak VO2 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0167-5273 1874-1754 |
| العلاقة: | urn:issn:0167-5273; urn:issn:1874-1754; https://orbi.uliege.be/handle/2268/140833Test; info:hdl:2268/140833; https://orbi.uliege.be/bitstream/2268/140833/1/impact%20of%20global%20dulgheru.pdfTest; scopus-id:2-s2.0-84885622639; info:pmid:23453444 |
| DOI: | 10.1016/j.ijcard.2013.01.205 |
| الإتاحة: | https://doi.org/10.1016/j.ijcard.2013.01.205Test https://orbi.uliege.be/handle/2268/140833Test https://orbi.uliege.be/bitstream/2268/140833/1/impact%20of%20global%20dulgheru.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.2266F023 |
| قاعدة البيانات: | BASE |
| تدمد: | 01675273 18741754 |
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| DOI: | 10.1016/j.ijcard.2013.01.205 |