Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols
| العنوان: | Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols |
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| المؤلفون: | Tania Marcourakis, Rodrigo S. Chaves, Karla P. Melo, Michael F. Almeida, Carolliny M. Silva, Sandra M. Cardoso, Marilene Demasi, Luis Eduardo Soares Netto, Merari F. R. Ferrari |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, medicine.medical_specialty, Insecticides, Physical exercise, Toxicology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Physical Conditioning, Animal, Rotenone, medicine, Animals, ESTRESSE OXIDATIVO, business.industry, General Neuroscience, Neurodegeneration, Autophagy, Motor Cortex, medicine.disease, Spinal cord, Rats, Oxidative Stress, 030104 developmental biology, Proteostasis, Endocrinology, medicine.anatomical_structure, Rats, Inbred Lew, Nerve Degeneration, Exercise Test, Neuron, business, 030217 neurology & neurosurgery, Oxidative stress, Motor cortex |
| الوصف: | Proteostasis and oxidative stress were evaluated in motor cortex and spinal cord of aged Lewis rats exposed to 1 mg/kg/day of rotenone during 4 or 8 weeks, prior or after practicing three protocols of mild treadmill running. Results demonstrated that exercise done after the beginning of neurodegeneration reverted the increased oxidative stress (measured by H2O2 levels and SOD activity), increased neuron strength, and improved proteostasis in motor cortex. Spinal cord was not affected. Treadmill running practiced before neurodegeneration protected cortical motor neurons of the rotenone-exposed rats; but in this case, oxidative stress was not altered, whereas proteasome activity was increased and autophagy decreased. Spinal cord was not protected when exercise was practiced before neurodegeneration. Prolonged treadmill running (10 weeks) increased oxidative stress, autophagy, and proteasome activity, whereas neuron viability was decreased in motor cortex. In spinal cord, this protocol decreased oxidative stress and increased proteasome activity. Major conclusions were that treadmill running practiced before or after the beginning of neurodegeneration may protect motor cortex neurons, whereas prolonged mild running seems to be beneficial for spinal cord. |
| تدمد: | 1476-3524 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358f5750b75a567d6c121c25aaf72c13Test https://pubmed.ncbi.nlm.nih.gov/30276717Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....358f5750b75a567d6c121c25aaf72c13 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14763524 |
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