التفاصيل البيبلوغرافية
| العنوان: |
Kinetics and utilization of lipid sources during acute exercise and acipimox. |
| المؤلفون: |
Nellemann, Birgitte1,2, Søndergaard, Esben1, Jensen, Jørgen2, Pedersen, Steen Bønløkke1, Jessen, Niels1,3, Lunde Jørgensen, Jens Otto1, Nielsen, Søren1 nielsen.soren@dadlnet.dk |
| المصدر: |
American Journal of Physiology: Endocrinology & Metabolism. Jul2014, Vol. 307 Issue 2, pE199-E208. 10p. |
| مصطلحات موضوعية: |
*LIPID metabolism, *PHYSIOLOGICAL effects of lipids, *EXERCISE, *OVERWEIGHT men, *PLACEBOS |
| مستخلص: |
Overweight is associated with abnormalities of lipid metabolism, many of which are reversed by exercise. We investigated the impact of experimental antilipolysis and acute exercise on lipid kinetics and oxidation from VLDL-TG, plasma FFA, and "residual lipids" in overweight men (n = 8) using VLDL-TG and palmitate tracers in combination with muscle biopsies in a randomized, placebo-controlled design. Participants received placebo or acipimox on each study day (4 h of rest, 90 min of exercise at 50% VO2 max). Exercise suppressed VLDL-TG secretion significantly during placebo but not acipimox (placebo-rest: 64.2 ± 9.4; placebo-exercise: 48.3 ± 8.0; acipimox-rest: 55.2 ± 13.4; acipimoxexercise: 52.0 ± 10.9). Resting oxidation of VLDL-TG FA and FFA was significantly reduced during acipimox compared with placebo, whereas "residual lipid oxidation" increased significantly [VLDL-TG oxidation (placebo: 18 ± 3 kcal/h; acipimox: 11 ± 2 kcal/h), FFA oxidation (placebo: 14 ± 2 kcal/h; acipimox: 4 ± 0.5 kcal/h), and residual lipid oxidation (placebo: 3 ± 5 kcal/h; acipimox: 14 ± 5 kcal/h)]. Additionally, during exercise on both placebo and acipimox, oxidation of VLDL-TG and FFA increased, but the relative contribution to total lipid oxidation diminished, except for FFA, which remained unchanged during acipimox. Residual lipid oxidation increased significantly during exercise in both absolute and relative terms. Changes in selected cellular enzymes and proteins provided no explanations for kinetic changes. In conclusion, suppressed FFA availability blunts the effect of exercise on VLDL-TG secretion and modifies the contribution of lipid sources for oxidation. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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