Efectos de la ssociación de estatina y del ejercicio aeróbico en los cardiomiocitos de rata. Estudio morfométrico
| العنوان: | Efectos de la ssociación de estatina y del ejercicio aeróbico en los cardiomiocitos de rata. Estudio morfométrico |
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| المؤلفون: | Mariana Rotta Bonfim, Reinaldo Azoubel, João Armando Padovani, Susimary Aparecida Trevizan Padulla, José Carlos Silva Camargo Filho, Antônio Carlos Brandão, Marilita Falangola Accioly, Dorotéia Rossi Silva Souza |
| المساهمون: | Universidade Estadual Paulista (Unesp), Univ Sao Jose do Rio Preto |
| المصدر: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP International Journal of Morphology v.27 n.1 2009 SciELO Chile CONICYT Chile instacron:CONICYT |
| بيانات النشر: | SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | medicine.medical_specialty, Statin, business.industry, medicine.drug_class, nutritional and metabolic diseases, Physical exercise, Cardiomyocite nuclei, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Internal medicine, Physical therapy, medicine, Anatomy, business, Exercise |
| الوصف: | Made available in DSpace on 2013-08-12T17:56:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-03-01 Made available in DSpace on 2013-09-30T18:09:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:23:18Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T13:23:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-03-01 Physical exercise and statins, recommended interventions to dyslipidaemia treatment, are independently related to cardiomyocytes alterations, characterized by miocardic hypertrophy and apoptosis, respectively. Thus, the objective of the present study was to analyze the effects of statin and aerobic physical exercise association in the morphometric parameters of cardiac cell nucleus. 40 male rats adults were divided into four groups: exercised (DE); sedentary (DS), exercised and statin use (DES); sedentary and statin use (DSS). The animals received during the whole experimental period a hiperlipidic diet added 20% of coconut oil and 1.25% of cholesterol; after 30 days of its ingestion, a blood collection was made to verify the dyslipidaemia. Simvastatin (20 mg) was taken five days a week, during eight weeks. During this period, the animals exercised 60 minutes daily in the treadmill. After the last day of the protocol, the cardiac muscle was collected and maintained in liquid nitrogen (-180 degrees C); the cuts were stained by Hematoxilin-Eosin method, and the cardiac fibers were submitted to the nuclear morphometric analyses. The data were analyzed using descriptive analyses, paired T test, Kruskal-Wallis test and Dunn post hoc test; for all analyses, it was adopted p |
| وصف الملف: | text/html |
| تدمد: | 0717-9502 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36da308fc44a869f440d44137797cde6Test https://doi.org/10.4067/s0717-95022009000100015Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....36da308fc44a869f440d44137797cde6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 07179502 |
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