Effect of Statins and Aerobic Physical Exercise on Liver Function in Dyslipidemic Rats: Morphometric Study
| العنوان: | Effect of Statins and Aerobic Physical Exercise on Liver Function in Dyslipidemic Rats: Morphometric Study |
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| المؤلفون: | Susimary Aparecida Trevizan Padulla, José Carlos Silva Camargo Filho, Alex Tadeu Martins, Reinaldo Azoubel, Antônio Carlos Brandão, Marilita Falângola Accioly, Edna Maria do Carmo, Dorotéia Rossi Silva Souza |
| المساهمون: | Universidade Federal do Triângulo Mineiro (UFTM), Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp), Univ Ctr Educ Fundat Barretos UNIFEB |
| المصدر: | International Journal of Morphology v.31 n.4 2013 SciELO Chile CONICYT Chile instacron:CONICYT Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| بيانات النشر: | Sociedad Chilena de Anatomía, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Pathology, Simvastatin, Cariometry, business.industry, H&E stain, Physical exercise, Staining, Diet, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Endocrinology, Internal medicine, Statistical significance, medicine, Liver function, Anatomy, business, Exercise, medicine.drug |
| الوصف: | Made available in DSpace on 2014-12-03T13:11:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-12-01Bitstream added on 2014-12-03T13:22:30Z : No. of bitstreams: 1 S0717-95022013000400026.pdf: 185254 bytes, checksum: 7ed45698a019ed46fe39936696bd7b80 (MD5) The present study was carried out to evaluate the effect of statins associated with physical exercise (PE) in liver cells in dyslipidemic rats through cariometry. The animals were divided into six groups: animals subjected to a hypercholesterolemic diet (HD), simvastatin, with (G1) and without (G2) physical exercise (PE); HD submitted (G3) or not (G4) to PE, and commercial food diet (F) with (G5) and without (G6) PE. Histological analysis of the liver was performed by staining the slides with hematoxylin and eosin. The cariometric study included measuring the major and minor diameters of the hepatocytes nuclei. The Shapiro-Wilk test was also performed. To determine the differences among the groups, the Kruskal-Wallis Test with Dunn's post-test were conducted. The significance level was set at 5%. No difference was found in the hepatocytes nuclei between G5 and G6. When these groups were related with G3 and G4, reduced nuclei were observed. There was no difference between G1 and G6. The comparison between G6 and G2 showed that the nuclei in G2 were smaller. No difference was detected between G5 and G1. Changes were observed in the nuclei shape in G2 in comparison to G1. Considering G2 and G3, a decrease in the size of nuclei was observed in G3. On the other hand, G2 showed changes in shape in the comparative analysis with G4. The size and shape of G1 nuclei were larger than G3 as well as changes in shape were observed when compared to G4. G4 showed smaller nuclei than G3. Therefore, F, associated or not with the practice of PE, does not alter the size and shape of the hepatocytes nuclei; HD combined with sedentarism influences changes in the morphometric parameters of hepatocytes; and the association of simvastatin and PE seems to protect the hepatocytes nuclei with regard to HD. Univ Fed Triangulo Mineiro, Dept Appl Phys Therapy, Uberaba, MG, Brazil Fac Med Sao Jose Rio Preto FAMERP, Sao Jose do Rio Preto, SP, Brazil FCT UNESP, Dept Phys Therapy, Campus Presidente Pruden, SP, Brazil Univ Ctr Educ Fundat Barretos UNIFEB, Program Dent Sci, Barretos, SP, Brazil Fac Med Sao Jose Rio Preto FAMERP, Hlth Sci Program, Sao Jose do Rio Preto, SP, Brazil FCT UNESP, Dept Phys Therapy, Campus Presidente Pruden, SP, Brazil |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 0717-9502 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6534366e7d2059aa09667ef4567cabTest http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000400026Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6f6534366e7d2059aa09667ef4567cab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 07179502 |
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