التفاصيل البيبلوغرافية
| العنوان: |
Detection and molecular characterization of the novel recombinant norovirus GII.P16-GII.4 Sydney in southeastern Brazil in 2016. |
| المؤلفون: |
Barreira, Débora Maria Pires Gonçalves, Fumian, Túlio Machado, Tonini, Marco André Loureiro, Volpini, Lays Paula Bondi, Santos, Rodrigo Pratte, Ribeiro, Anézia Lima Chaves, Leite, José Paulo Gagliardi, Souza, Márcia Terezinha Baroni de Moraes e, Brasil, Patrícia, da Cunha, Denise Cotrim, Miagostovich, Marize Pereira, Spano, Liliana Cruz |
| المصدر: |
PLoS ONE; 12/13/2017, Vol. 12 Issue 12, p1-9, 9p |
| مصطلحات موضوعية: |
NOROVIRUSES, GASTROENTERITIS, PUBLIC health, CHILDREN'S hospitals, CALICIVIRUSES |
| مستخلص: |
Noroviruses are the leading cause of acute gastroenteritis (AGE) in all age groups worldwide. Despite the high genetic diversity of noroviruses, most AGE outbreaks are caused by a single norovirus genotype: GII.4. Since 1995, several different variants of norovirus GII.4 have been associated with pandemics, with each variant circulating for 3 to 8 years. The Sydney_2012 variant was first reported in Australia and then in other countries. A new variant, GII.P16-GII.4, was recently described in Japan and South Korea and then in the USA, France, Germany and England. In our study, 190 faecal specimens were collected from children admitted to a paediatric hospital and a public health facility during a surveillance study of sporadic cases of AGE conducted between January 2015 and July 2016. The norovirus was detected by RT-qPCR in 51 samples (26.8%), and in 37 of them (72.5%), the ORF1-2 junction was successfully sequenced. The new recombinant GII.P16-GII.4 Sydney was revealed for the first time in Brazil in 2016 and predominated among other strains (9 GII.Pe-GII.4, 3 GII.P17-GII.17, 1 GII.Pg-GII.1, 1 GII.P16-GII.3 and 1 GII.PNA-GII.4). The epidemiological significance of this new recombinant is still unknown, but continuous surveillance studies may evaluate its impact on the population, its potential to replace the first recombinant GII.Pe-GII.4 Sydney 2012 variant, and the emergence of new recombinant forms of GII.P16. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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