A high density recombination map of the pig reveals a correlation between sex-specific recombination and GC content
| العنوان: | A high density recombination map of the pig reveals a correlation between sex-specific recombination and GC content |
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| المؤلفون: | Gary A. Rohrer, Jonathan E. Beever, Ralph T Wiedmann, Laurent A. F. Frantz, Hendrik-Jan Megens, Alan Archibald, Flavie Tortereau, Martien A. M. Groenen, Denis Milan, Bertrand Servin, Lawrence B. Schook |
| المساهمون: | Laboratoire de Génétique Cellulaire (LGC), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Animal Breeding and Genomics Centre, Wageningen University and Research [Wageningen] (WUR), United States Department of Agriculture (USDA), University of Illinois System, University of Edinburgh, Groenen, Martien A.M. |
| المصدر: | BMC Genomics, Vol 13, Iss 1, p 586 (2012) BMC Genomics, 13 BMC Genomics BMC Genomics, BioMed Central, 2012, 13, online (november), Non paginé. ⟨10.1186/1471-2164-13-586⟩ Tortereau, F, Servin, B, Frantz, L, Megens, H-J, Milan, D, Rohrer, G, Wiedmann, R, Beever, J, Archibald, A L, Schook, L B & Groenen, M A 2012, ' A high density recombination map of the pig reveals a correlation between sex-specific recombination and GC content ', BMC Genomics, vol. 13, 586 . https://doi.org/10.1186/1471-2164-13-586Test BMC Genomics november (13, online), Non paginé. (2012) BMC Genomics 13 (2012) |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Isochore, hot-spots, Genetic Linkage, [SDV]Life Sciences [q-bio], Sus scrofa, rates, Genome, biased gene conversion, humans, Recombination, Genetic, Genetics, Base Composition, 0303 health sciences, Linkage, Chromosome Mapping, pig, recombination, genome, snp, linkage, meiosis, telomere, centromere, isochore, 04 agricultural and veterinary sciences, Telomere, SNP genotyping, Meiosis, Female, Recombination, multipoint linkage analysis, Research Article, Biotechnology, Genome evolution, mice, Genotype, lcsh:QH426-470, lcsh:Biotechnology, Quantitative Trait Loci, Centromere, interference, SNP, sus-scrofa, Single-nucleotide polymorphism, Quantitative trait locus, Biology, Animal Breeding and Genomics, Polymorphism, Single Nucleotide, Chromosomes, 03 medical and health sciences, porcine genome, Genetic linkage, lcsh:TP248.13-248.65, evolution, Animals, Fokkerij en Genomica, 030304 developmental biology, Pig, 0402 animal and dairy science, Chromosome, 040201 dairy & animal science, lcsh:Genetics, WIAS |
| الوصف: | Background The availability of a high-density SNP genotyping chip and a reference genome sequence of the pig (Sus scrofa) enabled the construction of a high-density linkage map. A high-density linkage map is an essential tool for further fine-mapping of quantitative trait loci (QTL) for a variety of traits in the pig and for a better understanding of mechanisms underlying genome evolution. Results Four different pig pedigrees were genotyped using the Illumina PorcineSNP60 BeadChip. Recombination maps for the autosomes were computed for each individual pedigree using a common set of markers. The resulting genetic maps comprised 38,599 SNPs, including 928 SNPs not positioned on a chromosome in the current assembly of the pig genome (build 10.2). The total genetic length varied according to the pedigree, from 1797 to 2149 cM. Female maps were longer than male maps, with a notable exception for SSC1 where male maps are characterized by a higher recombination rate than females in the region between 91–250 Mb. The recombination rates varied among chromosomes and along individual chromosomes, regions with high recombination rates tending to cluster close to the chromosome ends, irrespective of the position of the centromere. Correlations between main sequence features and recombination rates were investigated and significant correlations were obtained for all the studied motifs. Regions characterized by high recombination rates were enriched for specific GC-rich sequence motifs as compared to low recombinant regions. These correlations were higher in females than in males, and females were found to be more recombinant than males at regions where the GC content was greater than 0.4. Conclusions The analysis of the recombination rate along the pig genome highlighted that the regions exhibiting higher levels of recombination tend to cluster around the ends of the chromosomes irrespective of the location of the centromere. Major sex-differences in recombination were observed: females had a higher recombination rate within GC-rich regions and exhibited a stronger correlation between recombination rates and specific sequence features. |
| وصف الملف: | application/octet-stream; application/pdf |
| اللغة: | English |
| تدمد: | 1471-2164 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1d80d48683492e88fdab0230944b86Test https://doi.org/10.1186/1471-2164-13-586Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fc1d80d48683492e88fdab0230944b86 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712164 |
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