التفاصيل البيبلوغرافية
| العنوان: |
Severe varicella-zoster virus pneumonia: a multicenter cohort study. |
| المؤلفون: |
Mirouse, Adrien, Vignon, Philippe, Piron, Prescillia, Robert, René, Papazian, Laurent, Géri, Guillaume, Blanc, Pascal, Guitton, Christophe, Guérin, Claude, Bigé, Naïke, Rabbat, Antoine, Lefebvre, Aurélie, Razazi, Keyvan, Fartoukh, Muriel, Mariotte, Eric, Bouadma, Lila, Ricard, Jean-Damien, Seguin, Amélie, Souweine, Bertrand, Moreau, Anne-Sophie |
| المصدر: |
Critical Care; 6/7/2017, Vol. 21, p1-10, 10p |
| مصطلحات موضوعية: |
ARTIFICIAL respiration, COMPARATIVE studies, HEALTH status indicators, HERPESVIRUSES, LENGTH of stay in hospitals, INTENSIVE care units, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PNEUMONIA, RESEARCH, EVALUATION research, RETROSPECTIVE studies, HOSPITAL mortality, ODDS ratio, DISEASE complications |
| مصطلحات جغرافية: |
FRANCE |
| مستخلص: |
Background: Pneumonia is a dreaded complication of varicella-zoster virus (VZV) infection in adults; however, the data are limited. Our objective was to investigate the clinical features, management, and outcomes of critically ill patients with VZV-related community-acquired pneumonia (VZV-CAP).Methods: This was an observational study of patients with VZV-CAP admitted to 29 intensive care units (ICUs) from January 1996 to January 2015.Results: One hundred and two patients with VZV-CAP were included. Patients were young (age 39 years (interquartile range 32-51)) and 53 (52%) were immunocompromised. Time since respiratory symptom onset was 2 (1-3) days. There was a seasonal distribution of the disease, with more cases during spring and winter time. All but four patients presented with typical skin rash on ICU admission. Half the patients received mechanical ventilation within 1 (1-2) day following ICU admission (the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) = 150 (80-284), 80% with acute respiratory distress syndrome (ARDS)). Sequential Organ Failure Assessment (SOFA) score on day 1 (odds ratio (OR) 1.90 (1.33-2.70); p < 0.001), oxygen flow at ICU admission (OR 1.25 (1.08-1.45); p = 0.004), and early bacterial co-infection (OR 14.94 (2.00-111.8); p = 0.009) were independently associated with the need for mechanical ventilation. Duration of mechanical ventilation was 14 (7-21) days. ICU and hospital mortality rates were 17% and 24%, respectively. All patients were treated with aciclovir and 10 received adjunctive therapy with steroids. Compared to 60 matched steroid-free controls, patients treated with steroids had a longer mechanical ventilation duration, ICU length of stay, and a similar hospital mortality, but experienced more ICU-acquired infections.Conclusions: Severe VZV-CAP is responsible for an acute pulmonary involvement associated with a significant morbidity and mortality. Steroid therapy did not influence mortality, but increased the risk of superinfection. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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