التفاصيل البيبلوغرافية
| العنوان: |
Antimicrobial management of Tropheryma whipplei endocarditis: the Spanish Collaboration on Endocarditis (GAMES) experience |
| المؤلفون: |
Garcia-Alvarez, L., Sanz, M. M., Marin, M., Farinas, M. C., Montejo, M., Goikoetxea, J., Garcia, R. R., de Alarcon, A., Almela, M., Fernandez-Hidalgo, N., Socas, M. M. A., Goenaga, M. A., Navas, E., Vicioso, L., Oteo, J. A., Adan, I., Sanchez, F. F., Noureddine, M., Rosas, G., Lima, J. D., Aramendi, J., Bereciartua, E., Boado, M. V., Lazaro, M. C., Goiti, J. J., Hernandez, J. L., Iruretagoyena, J. R., Zuazabal, J. I., Lopez-Soria, L., Perez, P. M., Rodriguez, R., Voces, R., Lopez, M. V. G., Georgieva, R. I., Solero, M. M., Bailon, I. R., Morales, J. R., Cuende, A. M., Echeverria, T., Fuerte, A., Gaminde, E., Idigoras, P., Iribarren, J. A., Yarza, A. I., Urkola, X. K., Reviejo, C., Carrasco, R., Climent, V., Llamas, P., Merino, E., Plazas, J., Reus, S., Alvarez, N., Bravo-Ferrer, J. M., Castelo, L., Cuenca, J., Llinares, P., Rey, E. M., Mayo, M. R., Sanchez, E., Regueiro, D. S., Martinez, F. J., Alonso, M. D., Castro, B., Marrero, D. G., Duran, M. D., Gomez, M. A. M., La Calzada, J., Nassar, I., Ciezar, A. P., Iglesias, J. M. R., Alvarez, V. A., Costas, C., de la Hera, J., Suarez, J. F., Fraile, L. I., Arguero, V. L., Menendez, J. L., Bajo, P. M., Morales, C., Torrico, A. M., Palomo, C., Martinez, B. P., Esteban, A. R., Asensio, M. T., Ambrosioni, J., Armero, Y., Azqueta, M., Brunet, M., Cartana, R., Falces, C., Fita, G., Fuster, D., de la Maria, C. G., Gatell, J. M., Perez, J. L., Manzardo, C., Marco, F., Miro, J. M., Moreno, A., Ninot, S., Quintana, E., Pare, C., Pereda, D., Pericas, J. M., Pomar, J. L., Ramirez, J., Rovira, I., Sitges, M., Soy, D., Tellez, A., Vidal, B., Vila, J., Bermejo, J., Bouza, E., Cuerpo, G., de Egea, V., Eworo, A., Cruz, A. F., Leoni, M. E. G., del Vecchio, M. G., Ramallo, V. G., Hernandez, M. K., Martinez-Selles, M., Menarguez, M. C., Munoz, P., Rincon, C., Rodriguez-Abella, H., Rodriguez-Creixems, M., Pinilla, B., Pinto, A., Valerio, M., Moreno, E. V., Antorrena, I., Loeches, B., Moreno, M., Ramirez, U., Baston, V. R., Romero, M., Saldana, A., Castillo, C. A., Arnaiz, A., Berrazueta, J., Bellisco, S., Belaustegui, M. C., Duran, R., Farinas-Alvarez, C., Mazarrasa, C. F., Izquierdo, R. G., Rico, C. G., Diez, J. G., Duran, R. M., Pajaron, M., Parra, J. A., Teira, R., Zarauza, J., Pavia, P. G., Gonzalez, J., Orden, B., Ramos, A., Gonzalez, E. R., Centella, T., Hermida, J. M., Moya, J. L., Martin-Davila, P., Oliva, E., del Rio, A., Ruiz, S., Tenorio, C. H., de Castro, A., de Cueto, M., Gallego, P., Acebal, J. G., Bano, J. R., Garcia, E., Haro, J. L., Lepe, J. A., Lopez, F., Luque, R., Alonso, L. J., Azcarate, P., Gutierrez, J. M. A., Blanco, J. R., de Benito, N., Gurgui, M., Pacho, C., Pericas, R., Pons, G., Alvarez, M., Fernandez, A. L., Martínez Monzonís, Maria Amparo, Prieto, A., Regueiro García, Benito José, Tijeira, E., Vega Fernandez, Marino, Blasco, A. C., Mollar, J. C., Arana, J. C. G., Uriarte, O. G., Lopez, A. M., de Zarate, Z. O., Matos, J. A. U., Nacle, M. B., Sanchez-Porto, A., Vallejo, L., Leal, J. M. A., Vazquez, E. G., Torres, A. H., Blazquez, A., Valenzuela, G. D., Alonso, A., Aramburu, J., Calvo, F. E., Rodriguez, A. M., Tarabini-Castellani, P., Galvez, E. H., Bellido, C. M., Pau, J. L., Sepulveda, M. A., Sierra, P. T., Iqbal-Mirza, S. Z., Alcolea, E. C., Serrano, P. E., Roca, J. J. H., Escobar, E. M., Monje, A. P., Cabrera, V. S., Garcia, D. V., Luna, C. C., Morcillo, J. N., Seco, M. C. P., Spanish Collaboration, Endocarditis |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
Drug Therapy, Endocarditis, Middle Aged, Humans, Treatment Outcome, Follow-Up Studies, Tropheryma, Anti-Bacterial Agents, Aged, resultado del tratamiento, anciano, estudios de seguimiento, mediana edad, farmacoterapia, humanos, antibacterianos, CHUS |
| الوصف: |
OBJECTIVES: Tropheryma whipplei has been detected in 3.5% of the blood culture-negative cases of endocarditis in Spain. Experience in the management of T. whipplei endocarditis is limited. Here we report the long-term outcome of the treatment of previously reported patients who were diagnosed with infective endocarditis (IE) caused by T. whipplei from the Spanish Collaboration on Endocarditis-Grupo de Apoyo al Manejo de la Endocarditis Infecciosa en Espana (GAMES) and discuss potential options for antimicrobial therapy for IE caused by T. whipplei. PATIENTS AND METHODS: Seventeen patients with T. whipplei endocarditis were recruited between 2008 and 2014 in 25 Spanish hospitals. Patients were classified according to the therapeutic regimen: ceftriaxone and trimethoprim/sulfamethoxazole, doxycycline + hydroxychloroquine and other treatment options. RESULTS: Follow-up data were obtained from 14 patients. The median follow-up was 46.5 months. All patients completed the antibiotic treatment prescribed, with a median duration of 13 months. Six patients were treated with ceftriaxone and trimethoprim/sulfamethoxazole (median duration 13 months), four with doxycycline + hydroxychloroquine (median duration 13.8 months) and four with other treatment options (median duration 22.3 months). The follow-up after the end of the treatments was between 5 and 84 months (median 24 months). CONCLUSIONS: All treatment lines were effective and well tolerated. Therapeutic failures were not detected during the treatment. None of the patients died or experienced a relapse during the follow-up. Only six patients received antibiotic treatment in accordance with guidelines. These data suggest that shorter antimicrobial treatments could be effective. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0305-7453 |
| العلاقة: |
https://watermark.silverchair.com/dkz059.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAApowggKWBgkqhkiG9w0BBwagggKHMIICgwIBADCCAnwGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM8YO84gG6gX6D1nybAgEQgIICTSRaTe_DdQ8k37Hpx_RivcUc7zFIrNXmTIGV5v0RV4QXcBBgS75MJfXYyyCFYM4H-VsFNr-p9aS1cu96vQIELqUug_qGpIsHoBUOiJ_4JfB6GI9mEOafo2y4D-MKYjipgHKV5Fkq3s49f15CCyNkuq6t5EKjD1I2onTIUW5ZUev2BMovcR3cBTUC-KUax-BAptcI68Xi-FaD6XFilV1oz0F84KYmrl7m8iycs2s7TJtvGZNaCtcmLG8gVKcfXuY22d-33Yxw4SBLjOkByIXHATmWDGKTNvqF-3dPsV1POW4KQjDS6gwikXiX_6g8UUnI8sOrbYT_1kKxl3yQpL51S1ORP6GZmf1Lh5gEeVmu-ebZmsUv0vDbPt3V7H8Rh98MmyIaDeAEVTXc2Ifaoa-alK_dsYou0zwcqvJT2uwD09V0BVDmm9I34FVQ63yM1o4zGAKSnUrIaN1Ljdq9IHRo7NfSPZMeJdN_LUFBzmOrMdhRQN-kQqYX8D9BsJuYht4TYI6KPcXPQYcjqWD5fsSn_-2PIOtw9V-tQ7HFAl0AT4mfHltdVRS42jMKA9CJ02OL8UeWQVZ2rxKgZaikP7ZFmZ2S2l4-SrrfkS1sutuAdnx8PrVVoFI_Y2mHVYnMnTluYQwXkwahf0A2zW1yTnVo743fX_r9MflqAHc2PVbDHLT4st7NUrZU3RzfeaNPabKtM1ZbFHBosySfxziO5x7fOd70e_f9rJfcXjvuKGNpwEksmJWatl6q3hTrbMbeQkBBeqbBoRCS50jaA_BssFQTest; https://www.ncbi.nlm.nih.gov/pubmed/30789210Test; http://hdl.handle.net/20.500.11940/15639Test; 31227 |
| DOI: |
10.1093/jac/dkz059 |
| الإتاحة: |
https://doi.org/20.500.11940/15639Test
https://doi.org/10.1093/jac/dkz059Test
https://hdl.handle.net/20.500.11940/15639Test
https://www.ncbi.nlm.nih.gov/pubmed/30789210Test |
| حقوق: |
embargoedAccess |
| رقم الانضمام: |
edsbas.F7A96E94 |
| قاعدة البيانات: |
BASE |
