دورية أكاديمية
Impact of a high-fat diet on the fatty acid composition of the retina
| العنوان: | Impact of a high-fat diet on the fatty acid composition of the retina |
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| المؤلفون: | Albouery, Mayssa, Buteau, Bénédicte, Grégoire, Stéphane, Martine, Lucy, Gambert, Ségolène, Bron, Alain, M., Acar, Niyazi, Chassaing, Benoit, Bringer, Marie-Agnès |
| المساهمون: | Centre des Sciences du Goût et de l'Alimentation Dijon (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de biochimie médicale (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service d'Ophtalmologie (CHU de Dijon), Georgia State University, University System of Georgia (USG), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), The Agence Nationale de la Recherche ANR-11-LABX-0021-01, INRAE, the Conseil Régional de Bourgogne, Franche-Comté PARI grant, the FEDER (European Funding for Regional Economical Development), and the Fondation de France/Fondation de l'oeil., ANR-11-LABX-0021,Lipstic,Lipoprotéines et santé : prévention et traitement des maladies inflammatoires non vasculaires et du cancer(2011) |
| المصدر: | ISSN: 0014-4835. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | retina, high-fat diet, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, plasmalogens, essential fatty acids, metabolic syndrome, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs |
| الوصف: | International audience ; Structure and function of the retina mainly rely on its fatty acid (FA) composition. Evidence from epidemiological studies and from animal experiments indicates that FA composition of the retina is influenced by the diet. Mice under chronic high-fat diet (HFD) develop metabolic syndrome, a risk factor for diabetes that is associated with structural and functional alterations of the retina. Here, we studied the impact of chronic exposure of mice to HFD on retinal FA composition. C57BL/6 J male mice were fed either a chow diet or a HFD for 11 weeks. As expected, HFD induced weight gain, adiposity, hyperglycemia and dyslipidemia. The retinal FA composition was determined by gas chromatography coupled to flame ionization detection. No significant change in the relative abundance of total saturated FAs (SFAs), total monounsaturated FAs (MUFAs) or total polyunsaturated FAs (PUFAs) was observed. However, retinas of HFD-fed mice displayed decreased amounts of C24:0 (p = 0.0231), C16:1n-7 (p < 0.0001), C18:1n-7 (p < 0.0001), C20:3n-9 (p = 0.0425) and C20:3n-6 (p = 0.0008), and an increased amount of C20:2n-6 (p < 0.0001). In addition, the ratio of linoleic acid (C18:2n-6) to alpha-linolenic acid (C18:3n-3) was increased in the retinas of HFD-fed mice (15.0 +/- 0.8 versus 11.8 +/- 0.6 in HFD and CD, respectively, p = 0.0045). No modification in the contents of arachidonic acid (C20:4n-6, AA) and docosahexaenoic acid (C22:6n-3, DHA) were observed. Analysis of dimethylacetals (DMA), which are residues of plasmalogens (Pls), revealed that the amount of Pls containing octadecanal-aldehydes (DMA C18:0) was significantly increased in HFD-fed mice (p = 0.0447). This increase was, at least in part, balanced by a decrease in Pls containing 7-octadecanal-aldehydes (DMA C18:1n-7) (p = 0.0007). In conclusion, HFD had an impact on the relative proportion of essential dietary fatty acids linoleic acid and alpha-linolenic acid that are incorporated in the retina. However, this imbalance in PUFA ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32387380; hal-02885838; https://hal.inrae.fr/hal-02885838Test; PUBMED: 32387380; WOS: 000540257400008 |
| DOI: | 10.1016/j.exer.2020.108059 |
| الإتاحة: | https://doi.org/10.1016/j.exer.2020.108059Test https://hal.inrae.fr/hal-02885838Test |
| رقم الانضمام: | edsbas.4EB9FDE3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.exer.2020.108059 |
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