التفاصيل البيبلوغرافية
| العنوان: |
Cutaneous Findings in Hemophagocytic Lymphohistiocytosis. |
| المؤلفون: |
Zerah, Michele L., DeWitt, Christine A. |
| المصدر: |
Dermatology (10188665); Mar2015, Vol. 230 Issue 3, p234-243, 10p, 3 Diagrams, 2 Charts |
| مستخلص: |
Background: Cutaneous findings associated with hemophagocytic lymphohistiocytosis (HLH) remain largely undescribed in the literature, yet are substantial and correlative with disease course. Objective: To catalog the clinical findings of cutaneous eruptions associated with HLH. Methods: We performed a retrospective chart review of patients meeting the criteria for HLH at two hospitals over 5 years. All patients meeting the criteria for HLH as defined by the HLH-2004 protocol were included. Results: Cutaneous lesions were categorized based on clinical presentations and histology. Lesions independent of immunocompromised state were observed, including pyoderma gangrenosum, panniculitis, morbilliform eruptions, Stevens-Johnson syndrome, atypical targetoid lesions and bullae. Histologic findings were non-specific. Conclusion: Cutaneous eruptions as a consequence of HLH are variable in presentation and identified as a diagnosis of exclusion. Findings are both primarily and secondarily induced by altered immunity. Further study is needed to allow better understanding of the immunopathogenesis involved. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
