المؤلفون: Stefan A. Mann, Kanigula Mubagwa, Urs Thomet, Beatrice Mihaela Radu, Thomas Knott, Bogdan Amuzescu

المصدر: European Journal of Pharmacology

مصطلحات موضوعية: ERG1 Potassium Channel, Patch-Clamp Techniques, hERG, Action Potentials, Pharmacology, Inhibitory postsynaptic potential, Proarrhythmogenic risk predictor, Antiviral Agents, Risk Assessment, Article, Cytocentering automated patch-clamp, NAV1.5 Voltage-Gated Sodium Channel, Inhibitory Concentration 50, Chloroquine, medicine, Humans, Computer Simulation, Myocytes, Cardiac, Potassium Channels, Inwardly Rectifying, Correlation of Data, IC50, Proarrhythmia, Dose-Response Relationship, Drug, biology, SARS-CoV-2, Chemistry, Arrhythmias, Cardiac, Atrial fibrillation, Hydroxychloroquine, medicine.disease, Human induced pluripotent stem cell-derived cardiomyocyte, In vitro, COVID-19 Drug Treatment, Kinetics, HEK293 Cells, Potassium Channels, Voltage-Gated, Comprehensive in vitro proarrhythmia assay, KCNQ1 Potassium Channel, biology.protein, Biological Assay, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3aec1cdeb5b434f3d9232f4e3a2fb9Test
https://doi.org/10.1016/j.ejphar.2021.174632Test

المؤلفون: Manfred Kayser, Winand N.M. Dinjens, Germaine Liebrechts-Akkerman, Ronald van Marion, Fan Liu

المساهمون: Genetic Identification, Pathology

المصدر: Forensic Science International: Genetics, 46. Elsevier Ireland Ltd

مصطلحات موضوعية: Ankyrins, Forensic Genetics, 0301 basic medicine, ERG1 Potassium Channel, medicine.medical_specialty, Calcium Channels, L-Type, Bioinformatics, NAV1.5 Voltage-Gated Sodium Channel, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, ANK2, Genetics, Humans, Medicine, 030216 legal & forensic medicine, Potassium Channels, Inwardly Rectifying, Exome sequencing, Netherlands, Retrospective Studies, Cause of death, Massive parallel sequencing, biology, business.industry, Genetic Variation, High-Throughput Nucleotide Sequencing, Infant, Cardiac arrhythmia, KCNE2, Arrhythmias, Cardiac, Exons, Sudden infant death syndrome, 030104 developmental biology, Potassium Channels, Voltage-Gated, KCNQ1 Potassium Channel, cardiovascular system, biology.protein, Medical genetics, business, Sudden Infant Death

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91d0c13205aa2863a99c84625bb464bTest
https://pure.eur.nl/en/publications/9a5f3a28-e55e-4b78-8641-4319adbeee77Test

المؤلفون: Beth A. McNally, Matthew C. Trudeau, Zeus D. Pendon

المصدر: Journal of Biological Chemistry. 292:21548-21557

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, ERG1 Potassium Channel, hERG, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Membrane Biology, Fluorescence Resonance Energy Transfer, Humans, Protein Isoforms, Molecular Biology, Ion channel, biology, Chemistry, Myocardium, Heart, Cardiac action potential, Cell Biology, Ether-A-Go-Go Potassium Channels, Potassium channel, Long QT Syndrome, Protein Subunits, Electrophysiology, 030104 developmental biology, Förster resonance energy transfer, Potassium Channels, Voltage-Gated, Biophysics, biology.protein, Ion Channel Gating, 030217 neurology & neurosurgery, Cysteine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::837bf6a44fb9484a1001c998b7944b41Test
https://doi.org/10.1074/jbc.m117.816488Test

المؤلفون: Chung Chuan Chou, Hung Ta Wo, Ming Shien Wen, Hui Ling Lee, Po-Cheng Chang, Shien-Fong Lin, Yen Chu, Yu Chang Huang

المصدر: Cardiovascular Therapeutics
Cardiovascular Therapeutics, Vol 2019 (2019)

مصطلحات موضوعية: Male, 0301 basic medicine, ERG1 Potassium Channel, lcsh:Diseases of the circulatory (Cardiovascular) system, Myocardial Infarction, Tetrazoles, 030204 cardiovascular system & hematology, Ventricular Function, Left, Sacubitril, NAV1.5 Voltage-Gated Sodium Channel, Rats, Sprague-Dawley, 0302 clinical medicine, Heart Rate, Pharmacology (medical), Myocardial infarction, Ejection fraction, Aminobutyrates, General Medicine, Drug Combinations, Valsartan, Potassium Channels, Voltage-Gated, Cardiology, Female, Cardiology and Cardiovascular Medicine, Anti-Arrhythmia Agents, Erg, medicine.drug, Research Article, medicine.medical_specialty, Article Subject, Heart Ventricles, 03 medical and health sciences, Internal medicine, medicine, Animals, Enalapril, cardiovascular diseases, Heart Failure, Pharmacology, business.industry, Biphenyl Compounds, lcsh:RM1-950, Arrhythmias, Cardiac, Stroke Volume, medicine.disease, Disease Models, Animal, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, lcsh:RC666-701, Heart failure, Myocardial infarction complications, business

وصف الملف: text/xhtml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20f3aa681762e87bfd22ededfd062baTest
http://europepmc.org/articles/PMC6739798Test

المؤلفون: E. Ramos-Luis, Rocio Gil, Mario Páramo, F. Lotufo-Neto, Angel Carracedo, A.M. Bermejo, Montserrat Santori, Maria Brion, Alejandro Blanco-Verea, Mario Hiroyuki Hirata, Francesca Brisighelli, Juan Ansede-Bermejo, M. Martinez-Matilla

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: 0301 basic medicine, Male, ERG1 Potassium Channel, Potassium Channels, Pharmacogenomic Variants, Cardiomyopathy, Arrhythmias, Settore MED/03 - GENETICA MEDICA, Bioinformatics, Sudden cardiac death, Death, Sudden, 0302 clinical medicine, Medicine, Cytochrome P-450 CYP3A, Child, SUD, Voltage-Gated, High-Throughput Nucleotide Sequencing, Middle Aged, FARMACODINÂMICA, Death, Long QT Syndrome, Cytochrome P-450 CYP2D6, Potassium Channels, Voltage-Gated, Female, Cardiac, Adult, Adolescent, Genotype, CYP2C19, QT interval, Pathology and Forensic Medicine, 03 medical and health sciences, Young Adult, Genetic variation, Genetic susceptibility, Genetics, Genetic predisposition, Humans, Pharmacokinetics, Genetic Predisposition to Disease, 030216 legal & forensic medicine, Cytochrome P-450 CYP2C9, Cardiotoxicity, business.industry, Genetic Variation, Arrhythmias, Cardiac, medicine.disease, Sudden, Pharmacogenomic Testing, Drug-induced arrhythmia, Cytochrome P-450 CYP2C19, 030104 developmental biology, Pharmacodynamics, Channelopathies, business, Adverse drug reaction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c73baa7443eacc48d2094253e90fbaTest
https://pubmed.ncbi.nlm.nih.gov/31376648Test

المؤلفون: Sung-Ae Hyun, Jong-Hak Chae, Ki-Suk Kim, Byungjin Byun, Hyang-Ae Lee

المصدر: PLoS ONE
PLoS ONE, Vol 13, Iss 4, p e0195577 (2018)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, ERG1 Potassium Channel, Patch-Clamp Techniques, Physiology, lcsh:Medicine, Action Potentials, 030204 cardiovascular system & hematology, Vandetanib, Biochemistry, Ion Channels, NAV1.5 Voltage-Gated Sodium Channel, 0302 clinical medicine, Piperidines, Animal Cells, Medicine and Health Sciences, Myocyte, Myocytes, Cardiac, lcsh:Science, Mammals, Multidisciplinary, biology, Rectifiers, Chemistry, Physics, Eukaryota, Depolarization, Animal Models, Potassium channel, Electrophysiology, medicine.anatomical_structure, Bioassays and Physiological Analysis, Experimental Organism Systems, Potassium Channels, Voltage-Gated, Physical Sciences, Vertebrates, KCNQ1 Potassium Channel, Leporids, Engineering and Technology, Female, Rabbits, Cellular Types, Anatomy, medicine.drug, Research Article, Purkinje fibers, hERG, Induced Pluripotent Stem Cells, Biophysics, Muscle Tissue, Neurophysiology, In Vitro Techniques, Research and Analysis Methods, Membrane Potential, Cardiotoxins, Purkinje Fibers, 03 medical and health sciences, medicine, Animals, Humans, Patch clamp, Potassium Channels, Inwardly Rectifying, Protein Kinase Inhibitors, Pharmacology, Cardiotoxicity, Muscle Cells, Drug Screening, lcsh:R, Electrophysiological Techniques, Organisms, Biology and Life Sciences, Proteins, Cell Biology, Electrophysiological Phenomena, 030104 developmental biology, Biological Tissue, HEK293 Cells, Amniotes, biology.protein, Quinazolines, lcsh:Q, Cardiac Electrophysiology, Electronics, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e34fb502c1c03009f2d2888aca2ed63Test
http://europepmc.org/articles/PMC5891061Test

المؤلفون: Hyungki Lee, Sung-Gap Lee, Sung Joon Kim, Kisok Kim

المصدر: Human & Experimental Toxicology. 35:501-510

مصطلحات موضوعية: 0301 basic medicine, ERG1 Potassium Channel, medicine.medical_specialty, Patch-Clamp Techniques, Health, Toxicology and Mutagenesis, hERG, Cell Culture Techniques, Action Potentials, Pharmacology, Transfection, Toxicology, QT interval, 03 medical and health sciences, Internal medicine, medicine, Humans, Myocytes, Cardiac, Patch clamp, Ion channel, Cardiotoxicity, Dose-Response Relationship, Drug, biology, Chemistry, Cardiac arrhythmia, Trazodone, Cardiac action potential, General Medicine, HEK293 Cells, 030104 developmental biology, Endocrinology, Potassium Channels, Voltage-Gated, KCNQ1 Potassium Channel, biology.protein, Antidepressive Agents, Second-Generation, Selective Serotonin Reuptake Inhibitors, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c01ef7353da60a8cb5d2a2908a42f3Test
https://doi.org/10.1177/0960327115595683Test

المؤلفون: Jinjun Liang, Zhaohui Yao, Chao Shen, Congxin Huang, Li Li

المصدر: Genetic Testing and Molecular Biomarkers. 19:359-365

مصطلحات موضوعية: Male, ERG1 Potassium Channel, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Haploview, Single-nucleotide polymorphism, Bioinformatics, Polymorphism, Single Nucleotide, law.invention, Gene Frequency, Risk Factors, law, Internal medicine, Atrial Fibrillation, Genotype, medicine, Humans, Genetic Predisposition to Disease, International HapMap Project, Genetic Association Studies, Genetics (clinical), Polymerase chain reaction, Aged, Retrospective Studies, business.industry, Age Factors, Cardiac arrhythmia, Atrial fibrillation, General Medicine, Odds ratio, Middle Aged, medicine.disease, Ether-A-Go-Go Potassium Channels, Potassium Channels, Voltage-Gated, Case-Control Studies, KCNQ1 Potassium Channel, cardiovascular system, Cardiology, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba99fbf52c701c120c50c05586719083Test
https://doi.org/10.1089/gtmb.2014.0307Test

المؤلفون: Ji Yeon Lee, Ki Duck Ahn, Sung Kim, Poong-Lyul Rhee, Eunju Ko

المصدر: American Journal of Physiology-Gastrointestinal and Liver Physiology

مصطلحات موضوعية: Male, ERG1 Potassium Channel, BK channel, medicine.medical_specialty, Patch-Clamp Techniques, Time Factors, Charybdotoxin, Small-Conductance Calcium-Activated Potassium Channels, Physiology, Apamin, gastrointestinal motility, Neuroregulation and Motility, Membrane Potentials, chemistry.chemical_compound, human stomach, KATP Channels, Physiology (medical), Internal medicine, Potassium Channel Blockers, medicine, Humans, Patch clamp, Potassium Channels, Inwardly Rectifying, smooth muscle cell, Membrane potential, Tetraethylammonium, Hepatology, biology, resting membrane potentials, Reverse Transcriptase Polymerase Chain Reaction, Chemistry, Stomach, Gastroenterology, Muscle, Smooth, Depolarization, Potassium channel blocker, Middle Aged, Ether-A-Go-Go Potassium Channels, Endocrinology, Gastric Mucosa, Potassium Channels, Voltage-Gated, slow wave potentials, Potassium, biology.protein, Biophysics, Female, Microelectrodes, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce4c7088176b7e4a84a9386de9e9b28Test
https://doi.org/10.1152/ajpgi.00220.2014Test

المؤلفون: Paul G.A. Volders, Kristina H. Haugaa, Michael J. Ackerman, Thor Edvardsen, Arthur van den Wijngaard, Rachel M.A. ter Bekke, J. Martijn Bos

المساهمون: RS: CARIM - R2 - Cardiac function and failure, Genetica & Celbiologie, Klinische Genetica, MUMC+: MA Med Staf Spec Cardiologie (9), MUMC+: DA KG Lab Centraal Lab (9), Cardiologie

المصدر: European Heart Journal, 36(3), 179-186. Oxford University Press

مصطلحات موضوعية: Adult, Male, ERG1 Potassium Channel, Heterozygote, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Genotype, Long QT syndrome, Adrenergic beta-Antagonists, Torsades de pointes, Long-QT syndrome, Sudden death, QT interval, Ion Channels, NAV1.5 Voltage-Gated Sodium Channel, Electrocardiography, Risk Factors, Internal medicine, medicine, Humans, cardiovascular diseases, Systole, Analysis of Variance, medicine.diagnostic_test, business.industry, Cardiac arrhythmia, Arrhythmias, Cardiac, Ultrasonography, Doppler, Odds ratio, medicine.disease, Ether-A-Go-Go Potassium Channels, Long QT Syndrome, Death, Sudden, Cardiac, Echocardiography, Potassium Channels, Voltage-Gated, Case-Control Studies, Anesthesia, KCNQ1 Potassium Channel, Mutation, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Anti-Arrhythmia Agents, Arrhythmia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c34e9c4708956b9a38652af8b10736Test
https://doi.org/10.1093/eurheartj/ehu370Test