التفاصيل البيبلوغرافية
| العنوان: |
Multiple sclerosis: The elevated antibody response to Epstein–Barr virus primarily targets, but is not confined to, the glycine–alanine repeat of Epstein–Barr nuclear antigen-1. |
| المؤلفون: |
Ruprecht, Klemens1,2 klemens.ruprecht@charite.de, Wunderlich, Benjamin1,2, Gieß, René1,2, Meyer, Petra3, Loebel, Madlen4, Lenz, Klaus5, Hofmann, Jörg6,7, Rosche, Berit1,2, Wengert, Oliver1,2, Paul, Friedemann1,2,8, Reimer, Ulf3, Scheibenbogen, Carmen4 |
| المصدر: |
Journal of Neuroimmunology. Jul2014, Vol. 272 Issue 1/2, p56-61. 6p. |
| مصطلحات موضوعية: |
*IMMUNOGLOBULINS, *EPSTEIN-Barr virus, *GLYCINE, *ALANINE, *MULTIPLE sclerosis, *EPITOPES |
| مستخلص: |
Abstract: Patients with multiple sclerosis (MS) have elevated antibodies against Epstein–Barr virus (EBV), but data on the epitope-resolved specificity of these antibodies are scarce. Using a peptide microarray containing 1465 peptides representing 8 full-length EBV proteins, we identified higher (p <0.001) antibody reactivities to 39 EBV-peptides in MS patients (n=29) compared to healthy controls (n=22). Seventeen of the 39 peptides were from EBNA-1 and 13 located within the glycine–alanine repeat of EBNA-1. Further reactivities were directed against EBNA-3, EBNA-4, EBNA-6, VP26, and LMP1. Thus, antibodies against EBV in MS patients primarily target, but are not confined to, the glycine–alanine repeat of EBNA-1. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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