التفاصيل البيبلوغرافية
| العنوان: |
Spatial and temporal intracerebral hemorrhage patterns in Dutch-type hereditary cerebral amyloid angiopathy. |
| المؤلفون: |
Voigt, Sabine1 (AUTHOR) s.voigt@lumc.nl, Amlal, Siham1 (AUTHOR), Koemans, Emma A1 (AUTHOR), Rasing, Ingeborg1 (AUTHOR), van Etten, Ellis S1 (AUTHOR), van Zwet, Erik W2 (AUTHOR), van Buchem, Mark A3 (AUTHOR), Terwindt, Gisela M1 (AUTHOR), van Walderveen, Marianne AA3 (AUTHOR), Wermer, Marieke JH1 (AUTHOR) |
| المصدر: |
International Journal of Stroke. Aug2022, Vol. 17 Issue 7, p793-798. 6p. |
| مصطلحات موضوعية: |
*CEREBRAL amyloid angiopathy, *CEREBRAL hemorrhage, *OCCIPITAL lobe, *FRONTAL lobe |
| مستخلص: |
Aim: To investigate whether there is a topographical and temporal pattern of index and recurrent intracerebral hemorrhages (ICH) in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA) to increase our understanding on CAA-related ICH development. Methods: We included patients with DNA confirmed D-CAA or a history with ≥1 lobar ICH and ≥1 first-degree relative with D-CAA. Topographical pattern was studied by location (proportion frontal/parietal/temporal/occipital; infra/supratentorial and occurrence ratios relative to lobe volume) and volume of index and recurrent ICHs were determined on CT. Temporal pattern was examined by time between recurrent ICHs was retrieved from medical records. Results: We included 72 patients with D-CAA (mean age at index ICH 55 years) with in total 214 ICH. The median follow-up time was 7 years (range 0.8 to 28 years). All ICH were lobar and supratentorial. The index ICH was most frequently located in the occipital lobe (34% vs. 22% in the other three lobes; with index ICH occurrence ratios relative to lobe volume of 1.9 for occipital, 1.0 for temporal, 1.2 for parietal, and 0.5 for frontal, p = 0.001). In 16/47 (34%) patients with multiple ICH, the second ICH was located in the same lobe as the index ICH. The median time-interval between subsequent ICH was #1-2 ICH 27 months, #2-3 ICH 14 months, and #3-4 ICH 7 months (p = 0.6) There was no difference in volume between index and recurrent ICHs. Conclusions: We found that index and recurrent ICHs in D-CAA have a preference for the occipital lobe and are least frequent in the frontal lobe, which adds to the existing knowledge of histopathological studies on amyloid load in CAA. Surprisingly, there was no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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