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1
المؤلفون: Nancy Torres, Eileen Frommer, Bloom Jonathan David, Karen Collins, Dunnick Alejandro Lee, George Diamantidis, Yongbo Hu, Minu Dutia, Christoph W. Zapf, Zhang Chunchun, Darrin William Hopper, Dan Maarten Berger, Donald Wojciechowicz, Dennis Powell, Martin Di Grandi, Jeremy I. Levin
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6957-6961
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyridines, Isostere, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Indazole, biology, Bicyclic molecule, Cell growth, Organic Chemistry, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6346230a46b93ee107f73ab7d8869701Test
https://doi.org/10.1016/j.bmcl.2009.10.058Test -
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المؤلفون: Steven C. Kim, Frederick Lee, Eileen Frommer, Mengxiao Shi, Yongbo Hu, Donald Wojciechowicz, Robert Mallon, Greg Ciszewski, Dan Maarten Berger, Karen Collins, Ariamala Gopalsamy, Larry Feldberg
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6890-6892
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyrimidine, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Carboxamide, Biochemistry, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Kinase, Organic Chemistry, Hit to lead, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Pyrazoles, Molecular Medicine, Signal transduction, Lead compound
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6af29a6344c217dfecdc0daf235230Test
https://doi.org/10.1016/j.bmcl.2009.10.074Test -
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المؤلفون: Edward J. Salaski, Wang Xiaolun, Dennis Powell, Donald Wojciechowicz, Eileen Frommer, Dan M. Berger, Karen Collins, Yongbo Hu
المصدر: Bioorganicmedicinal chemistry letters. 21(23)
مصطلحات موضوعية: Models, Molecular, Niacinamide, Proto-Oncogene Proteins B-raf, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Isoindoles, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Potency, Enzyme Inhibitors, Molecular Biology, Molecular Structure, Chemistry, Kinase, Phenylurea Compounds, Organic Chemistry, Benzenesulfonates, Imidazoles, Isoindoline, Sorafenib, Combinatorial chemistry, Enzyme Activation, Drug Design, Molecular Medicine, Structure based, Phthalazines, Selectivity
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2b84f81a40df7101d2b4f6a8635c87Test
https://pubmed.ncbi.nlm.nih.gov/22024030Test