Epidemiology and clinical characteristics of severe non-polio enteroviruses infections: the pediatric experience of the National Institute for Infectious Diseases 'Prof. Dr. Matei Balş', a 5 year survey
التفاصيل البيبلوغرافية
العنوان:
Epidemiology and clinical characteristics of severe non-polio enteroviruses infections: the pediatric experience of the National Institute for Infectious Diseases 'Prof. Dr. Matei Balş', a 5 year survey
Results There were 63 laboratory-confirmed enteroviruses severe infections during this period. In our cohort 67% of the patients were males and the median age was 4.2±2.2 years of age. The average days from onset to deterioration were 4.3 days (range 1–10 days). Interestingly, more than half did not have oral ulcers, and/or characteristic skin rashes, thus making earlier diagnosis more difficult. The vast majority (92% of the patients) associated gastrointestinal manifestations. A total of 23 patients were diagnosed with severe nonpolio enterovirus aseptic meningitis, with the highest prevalence of the cases in the summer of 2012, when 18 children developed acute flaccid paralysis, 13 manifested non-specific febrile skin rashes and 9 presented with viral hepatitis. The average time of hospitalization was 6.4 days (range 4-31 days) and all patients required interdisciplinary consults, 12 required kineto-therapy after discharge but neither one of our patients had a fatal outcome.
