دورية أكاديمية
Olfactory neuron substance P is overexpressed in Parkinson's disease reflecting gut dysfunction
| العنوان: | Olfactory neuron substance P is overexpressed in Parkinson's disease reflecting gut dysfunction |
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| المؤلفون: | Schirinzi, Tommaso, Maftei, Daniela, Grillo, Piergiorgio, Bovenzi, Roberta, Bissacco, Jacopo, Simonetta, Clara, Mascioli, Davide, Zenuni, Henri, Cerroni, Rocco, Vincenzi, Martina, Maurizi, Riccardo, Passali, Francesco M, Di Girolamo, Stefano, Ralli, Massimo, Magliulo, Giuseppe, Tirassa, Paola, Stefani, Alessandro, Mercuri, Nicola B, Lattanzi, Roberta, Severini, Cinzia |
| المساهمون: | Schirinzi, Tommaso, Maftei, Daniela, Grillo, Piergiorgio, Bovenzi, Roberta, Bissacco, Jacopo, Simonetta, Clara, Mascioli, Davide, Zenuni, Henri, Cerroni, Rocco, Vincenzi, Martina, Maurizi, Riccardo, Passali, Francesco M, Di Girolamo, Stefano, Ralli, Massimo, Magliulo, Giuseppe, Tirassa, Paola, Stefani, Alessandro, Mercuri, Nicola B, Lattanzi, Roberta, Severini, Cinzia |
| بيانات النشر: | John Wiley & Sons, Inc. Hoboken, NJ 07030 Stati Uniti |
| سنة النشر: | 2023 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Parkinson's disease (PD), neurokinin receptor 1 (NK1R), olfactory neurons (ONs), central nervous system, peripheral nervous system, enteric nervous system, immune cells |
| الوصف: | bstance P (SP) and its cognate Neurokinin receptor 1 (NK1R) are tachykinergic neuroinflammatory mediators widely expressed in the central nervous system, peripheral nervous system, enteric nervous system, and immune cells. The SP/NK1R pathway is activated by several noxious stimuli and triggers a sustained inflammatory response by inducing cytokines release from different cell subtypes. In Parkinson's disease (PD), SP colocalizes with α-synuclein in the central and peripheral structures more prone to degeneration, mostly within the gastrointestinal–nervous ascending system, suggesting a potential role in the disease pathogenesis through inflammation-related mechanisms. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/37157902; info:eu-repo/semantics/altIdentifier/wos/WOS:000984574700001; numberofpages:4; journal:MOVEMENT DISORDERS; https://hdl.handle.net/11573/1679667Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85158162279 |
| DOI: | 10.1002/mds.29433 |
| الإتاحة: | https://doi.org/10.1002/mds.29433Test https://hdl.handle.net/11573/1679667Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.174EFD30 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mds.29433 |
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