دورية أكاديمية
Evaluation of antiproliferative and protective effects of Eupatorium cannabinum L. extracts
| العنوان: | Evaluation of antiproliferative and protective effects of Eupatorium cannabinum L. extracts |
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| المؤلفون: | GRIGORE, ALICE, NEAGU, GEORGETA, DOBRE, NICOLETA, ALBULESCU, ADRIAN, IONITA, LUCIAN, IONITA, CARMEN, ALBULESCU, RADU |
| المصدر: | Turkish Journal of Biology |
| بيانات النشر: | TÃœBÄ°TAK Academic Journals |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Hemp-agrimony, antiinflammatory, methoxyflavones, endotoxemia, Biology |
| الوصف: | Eupatorium cannabinum L. (Asteraceae) has been used for a long time for medicinal purposes due to its various pharmacological effects and richness in active compounds such as phenolics, sesquiterpenes, pyrrolizidine alkaloids, and polysaccharides. Despite the high content of compounds that have important roles in medicinal plants, there are still limited literature data regarding this valuable species. The plant was fractioned using chloroform (EC) and distilled water (EA) and HPLC analysis revealed the presence of eupatorin, eupatilin, and quercetin in EC and caffeic acid and rutin in EA. The antiproliferative potential on BT-20, HepG2, Caco-2, and Jurkat cancer cell lines was assessed by MTS test. Jurkat cells were more sensitive to both extracts (IC50 of 7.35 ± 0.35 for EC and 13.77 ± 2.16 ?g/mL for EA), while the other lines were susceptible only to EC (IC50 88.27 ± 1.34 on Caco-2 cells and over 100 ?g/mL on BT- 20 and HepG2 cells) after 24 h of exposure. In an LPS-induced damage mouse model of endotoxemia, we showed that preventive administration increases the survival times of mice and leads to inhibition of proinflammatory cytokines. Both polar and nonpolar compounds are involved in exerting these effects, but further analytical studies are needed to identify the key responsible compounds and their biochemical pathways. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://journals.tubitak.gov.tr/biology/vol42/iss4/9Test; https://journals.tubitak.gov.tr/context/biology/article/1180/viewcontent/biy_42_4_9_1803_72.pdfTest |
| DOI: | 10.3906/biy-1803-72 |
| الإتاحة: | https://doi.org/10.3906/biy-1803-72Test https://journals.tubitak.gov.tr/biology/vol42/iss4/9Test https://journals.tubitak.gov.tr/context/biology/article/1180/viewcontent/biy_42_4_9_1803_72.pdfTest |
| رقم الانضمام: | edsbas.54ABCD37 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3906/biy-1803-72 |
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