المؤلفون: Matalliotakis, Ioannis, Cakmak, Hakan, Dermitzaki, Despina, Zervoudis, Stefanos, Goumenou, Anastasia, Fragouli, Yvoni

المصدر: Gynecological Endocrinology; Apr2008, Vol. 24 Issue 4, p194-198, 5p, 3 Charts

مصطلحات موضوعية: ENDOMETRIOSIS, FEMALE reproductive organ diseases, PELVIC diseases, FERTILIZATION in vitro, HUMAN fertility

مستخلص: Background. There are conflicting data concerning endometriosis and spontaneous abortion (SAB). The aim of the present study was to evaluate if there was any association between endometriosis and SAB. Moreover, we investigated risk factors in women with endometriosis and SAB. Methods. The medical files of 457 married women with endometriosis and 200 infertile women without endometriosis were studied retrospectively. All cases were diagnosed by laparoscopy. Data concerning demographic variables and menstrual characteristics were recorded from 226 women with endometriosis, which were divided into two groups. Group 1 included 126 cases with endometriosis and SAB, and Group 2 comprised 100 parous women with endometriosis and without SAB. Statistical comparisons between groups were made using the χ2 test and odds ratios (OR) and 95% confidence intervals (CI). Results. The proportion of SAB was significantly higher in women with endometriosis than in infertile women without endometriosis (126/457 (27.6%) vs. 36/200 (18.0% ); OR = 1.7, 95% CI 1.1 = 2.6; p = 0.01). The frequency of nulligravid women was significantly higher in women with endometriosis than in the control group (OR = 1.9, 95% CI 1.4 - 2.81; p = 0.001). Mean age, age at onset of endometriosis, race, height, weight, body mass index, medical history of allergies, and family histories of endometriosis and cancer were similar in women with endometriosis and SAB and in parous women with endometriosis but without SAB. Moreover, the two groups were similar in age at menarche, length of cycle, duration and amount of flow, and the severity of disease. The incidence of infertility was significantly higher in women with SAB (p < 0.001). Conclusion. These data suggest but do not prove that the risk of SAB is increased in women with endometriosis. The epidemiological risk factors of endometriosis are not associated with an increase in the abortion rate. [ABSTRACT FROM AUTHOR]

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المؤلفون: Matalliotakis, Ioannis M.^1,2 matakgr@yahoo.com, Cakmak, Hakan¹, Krasonikolakis, Georgios D.², Dermitzaki, Despina², Fragouli, Yvoni³, Vlastos, Georges⁴, Arici, Aydin¹

المصدر: Surgical Oncology. Mar2010, Vol. 19 Issue 1, p33-37. 5p.

مصطلحات موضوعية: *ENDOMETRIOSIS, *FAMILY history (Medicine), *LAPAROSCOPY, *OVARIAN tumors, *PROSTATE cancer, *COLON cancer, *GENETICS

مستخلص: Abstract: Objective: Recent studies reported that endometriosis could behave as a neoplasmatic process. The purpose of this study is to investigate the family risk of ovarian, colon and prostate cancer in women with endometriosis. Study design: A search of medical records at the Yale New Haven Hospital from 1996 to 2002 identified 348 women with endometriosis and 179 women without endometriosis. All the cases were diagnosed by laparoscopy. Demographic characteristics were evaluated in women with positive or negative family history of cancers in women with endometriosis. Results: The overall risk of patients with endometriosis and positive family history of cancers was 7.7 (95% confidence interval 3.8–15.7) (χ 2 =39.8, P <0.001). Significant excess was observed for ovarian cancer in first- and second-degree relatives (OR=10.5, 95% CI (2.5–44.2), χ 2 =14.3, P <0.001), colon cancer (OR=7.5, 95% CI (2.7–21.1), χ 2 =18.2, P <0.001) and prostate cancer (OR=4.5, 95% CI (14–15.3), χ 2 =6.1, P <0.001). We found similar results in first- and second-degree relatives with ovarian and colon cancer. Moreover, we found similar results regarding the demographic characteristics in women with positive family history of cancers and in women with negative history. Conclusions: These data suggest a familial association of endometriosis with ovarian, colon and prostate cancers. This evidence could support the genetics and molecular similarities between endometriosis and cancer. Future studies will be important to determine a clear genetic link between endometriosis and cancer. [Copyright &y& Elsevier]