المؤلفون: Sauvonnet, Nathalie, Dujeancourt, Annick, Dautry-Varsat, Alice

المصدر: The Journal of Cell Biology, 2005 Jan 01. 168(1), 155-163.

الوصول الحر: https://www.jstor.org/stable/3658071Test

المؤلفون: Kozyraki, Renata, Fyfe, John, Verroust, Pierre J., Jacobsen, Christian, Dautry-Varsat, Alice, Gburek, Jakub, Willnow, Thomas E., Christensen, Erik Ilsø, Moestrup, Søren K.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2001 Oct . 98(22), 12491-12496.

الوصول الحر: https://www.jstor.org/stable/3056933Test

المؤلفون: Benmerah, Alexandre, Lamaze, Christophe, Bègue, Bernadette, Schmid, Sandra L., Dautry-Varsat, Alice, Cerf-Bensussan, Nadine

المصدر: The Journal of Cell Biology, 1998 Mar 01. 140(5), 1055-1062.

الوصول الحر: https://www.jstor.org/stable/1618479Test

المؤلفون: Subtil, Agathe, Delepierre, Muriel, Dautry-Varsat, Alice

المصدر: The Journal of Cell Biology, 1997 Feb 01. 136(3), 583-595.

الوصول الحر: https://www.jstor.org/stable/1617891Test

المؤلفون: Benmerah, Alexandre, Gagnon, Jean, Bègue, Bernadette, Mégarbané, Bruno, Dautry-Varsat, Alice, Cerf-Bensussan, Nadine

المصدر: The Journal of Cell Biology, 1995 Dec 01. 131(6), 1831-1838.

الوصول الحر: https://www.jstor.org/stable/1617394Test

المؤلفون: Hémar, Agnès, Subtil, Agathe, Lieb, Michèle, Morelon, Emmanuel, Hellio, Raymond, Dautry-Varsat, Alice

المصدر: The Journal of Cell Biology, 1995 Apr 01. 129(1), 55-64.

الوصول الحر: https://www.jstor.org/stable/1616900Test

المؤلفون: Dautry-Varsat, Alice, Ciechanover, Aaron, Lodish, Harvey F.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 1983 Apr . 80(8), 2258-2262.

الوصول الحر: https://www.jstor.org/stable/13490Test

المؤلفون: Moya, Maryse, Dautry-Varsat, Alice, Goud, Bruno, Louvard, Daniel, Boquet, Patrice

المصدر: The Journal of Cell Biology, 1985 Aug 01. 101(2), 548-559.

الوصول الحر: https://www.jstor.org/stable/1611492Test

المؤلفون: Dautry-Varsat, Alice, Lodish, Harvey F.

المصدر: Scientific American, 1984 May 01. 250(5), 52-61.

الوصول الحر: https://www.jstor.org/stable/24969368Test

المؤلفون: Das, Vincent, Nal, Béatrice, Dujeancourt, Annick, Thoulouze, Maria-Isabel, Galli, Thierry, Roux, Pascal, Dautry-Varsat, Alice, Alcover, Andrès

المساهمون: Biologie des Interactions Cellulaires, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Transduction du Signal et Plasticite Dans Le Systeme Nerveux, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

المصدر: Immunity
Immunity, 2004, 20 (5), pp.577-88. ⟨10.1016/S1074-7613(04)00106-2⟩
Immunity, Elsevier, 2004, 20 (5), pp.577-88. ⟨10.1016/S1074-7613(04)00106-2⟩

مصطلحات موضوعية: MESH: Protein Transport, T-Lymphocytes, Receptors, Antigen, T-Cell, Vesicular Transport Proteins, Antigen-Presenting Cells, Fluorescent Antibody Technique, chemical and pharmacologic phenomena, Lymphocyte Activation, Image Processing, Computer-Assisted, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Lymphocyte Activation, MESH: Fluorescent Antibody Technique, MESH: Humans, MESH: Antigen-Presenting Cells, Cell Polarity, Membrane Proteins, hemic and immune systems, MESH: Receptors, Antigen, T-Cell, MESH: Vesi, MESH: Image Processing, Computer-Assisted, Endocytosis, Protein Transport, MESH: T-Lymphocytes, MESH: Endocytosis, MESH: Membrane Proteins, MESH: Cell Polarity, SNARE Proteins, MESH: SNARE Proteins

الوصف: The mechanism by which T cell antigen receptors (TCR) accumulate at the immunological synapse has not been fully elucidated. Since TCRs are continuously internalized and recycled back to the cell surface, we investigated the role of polarized recycling in TCR targeting to the immunological synapse. We show here that the recycling endosomal compartment of T cells encountering activatory antigen-presenting cells (APCs) polarizes towards the T cell-APC contact site. Moreover, TCRs in transit through recycling endosomes are targeted to the immunological synapse. Inhibition of T cell polarity, constitutive TCR endocytosis, or recycling reduces TCR accumulation at the immunological synapse. Conversely, increasing the amount of TCRs in recycling endosomes before synapse formation enhanced their accumulation. Finally, we show that exocytic t-SNAREs from T cells cluster at the APC contact site and that tetanus toxin inhibits TCR accumulation at the immunological synapse, indicating that vesicle fusion mediated by SNARE complexes is involved in TCR targeting to the immunological synapse.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::73e14d10fff5bcbf2ffd649d3f07eb07Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-00137478Test