Determination of bone mineral density by quantitative computed tomography and single photon absorptiometry in subclinical hyperthyroidism: a risk of early osteopaenia in post-menopausal women
| العنوان: | Determination of bone mineral density by quantitative computed tomography and single photon absorptiometry in subclinical hyperthyroidism: a risk of early osteopaenia in post-menopausal women |
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| المؤلفون: | J. Lehmke, Harm Peters, D. Felsenberg, Horst Schleusener, U. Bogner |
| المصدر: | Clinical Endocrinology. 36:511-517 |
| بيانات النشر: | Wiley, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Bone density, Endocrinology, Diabetes and Metabolism, Hyperthyroidism, Absorptiometry, Photon, Endocrinology, Bone Density, Internal medicine, medicine, Humans, Quantitative computed tomography, Aged, Subclinical infection, Aged, 80 and over, Bone mineral, medicine.diagnostic_test, biology, Bone decalcification, business.industry, Middle Aged, medicine.disease, Osteopenia, Bone Diseases, Metabolic, Calcaneus, Radius, Thyroxine, Thyroidectomy, Osteocalcin, biology.protein, Female, Menopause, Tomography, X-Ray Computed, Nuclear medicine, business |
| الوصف: | OBJECTIVE There is evidence that treatment with L-thyroxine increases the risk of early osteopaenia. The aim of our study was to investigate the effect of subclinical hyperthyroidism in patients on TSH-suppressive L-thyroxine in view of the increased risk of decalcification. DESIGN Measurements of bone mineral density were performed in patients with subclinical hyperthyroidism at different scanning sites of varying trabecular portion. Bone mineral values as well as biochemical data were compared to those of normal controls. PATIENTS Fifty patients (nine men, 25 premenopausal and 16 post-menopausal women) on TSH-suppressive doses of L-thyroxine were investigated after removal of thyroid cancer. MEASUREMENTS Dual energy quantitative computed tomography was used for osteodensitometry in the lumbar spine. Single photon absorptiometry from a 125I source was applied to the calcaneus, midshaft radius and distal as well as proximal scanning sites of the distal radius. Normal bone mineral values for each measurement site were taken from healthy reference populations. RESULTS A significant decrease of bone mineral density in the calcaneus was found in 26 of 50 patients. Bone mass assessment yielded a 9.1% decrease of mean bone mineral content in all patients compared to controls (P less than 0.01). The decrease in post-menopausal women was 22% (P less than 0.001). In premenopausal women bone mineral density changes in the calcaneus were not statistically significant. Cortical measurement sites like the midshaft radius and the proximal scanning site of the distal forearm showed a 14.8% (P less than 0.05) and 10.8% (P = NS) decalcification in post-menopausal women but normal values at the distal scanning site. The lumbar spine was not affected by subclinical hyperthyroidism in either pre or post-menopausal women. In hypoparathyroid patients, bone density did not essentially differ from normals. There was no significant correlation between bone mineral values and duration of treatment or osteocalcin values. CONCLUSIONS Our data suggest that TSH suppressive L-thyroxine treatment has a detrimental effect on the appendicular skeleton in post-menopausal women. Additional effects of oestrogen deficiency and subclinical hyperthyroidism might lead to accelerated bone loss requiring close supervision to determine the smallest dose needed for suppression of the pituitary-thyroid axis. |
| تدمد: | 1365-2265 0300-0664 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced75974a9250950b0f110e413335d87Test https://doi.org/10.1111/j.1365-2265.1992.tb02254.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ced75974a9250950b0f110e413335d87 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652265 03000664 |
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