التفاصيل البيبلوغرافية
| العنوان: |
Cobalt‐Catalyzed Enantioselective Synthesis of Chiral gem‐Bis(boryl)alkanes. |
| المؤلفون: |
Teo, Wei Jie1, Ge, Shaozhong1 chmgsh@nus.edu.sg |
| المصدر: |
Angewandte Chemie International Edition. 9/24/2018, Vol. 57 Issue 39, p12935-12939. 5p. |
| مصطلحات موضوعية: |
*ENANTIOSELECTIVE catalysis, *SESQUITERPENES, *BORENES, *STEREOSPECIFICITY, STEREOISOMERISM |
| مستخلص: |
Abstract: We report an asymmetric synthesis of enantioenriched gem‐bis(boryl)alkanes in an enantioselective diborylation of 1,1‐disubstituted alkenes catalyzed by Co(acac)2/(R)‐DM‐segphos. A range of activated and unactivated alkenes underwent this asymmetric diborylation in the presence of cyclooctene as a hydrogen acceptor, affording the corresponding gem‐bis(boryl)alkanes with high enantioselectivity. The synthetic utility of these chiral organoboronate compounds was demonstrated through several stereospecific derivatizations and the synthesis of sesquiterpene and sesquiterpenoid natural products. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
