دورية أكاديمية
Amygdala functional connectivity as a longitudinal biomarker of symptom changes in generalized anxiety
| العنوان: | Amygdala functional connectivity as a longitudinal biomarker of symptom changes in generalized anxiety |
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| المؤلفون: | Makovac, Elena, Watson, David R., Meeten, Frances, Garfinkel, Sarah N., Cercignani, Mara, Critchley, Hugo D., OTTAVIANI, CRISTINA |
| المساهمون: | Makovac, Elena, Watson, David R., Meeten, France, Garfinkel, Sarah N., Cercignani, Mara, Critchley, Hugo D., Ottaviani, Cristina |
| بيانات النشر: | Oxford Oxford University Press |
| سنة النشر: | 2016 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | amygdala functional connectivity, emotion regulation, generalized anxiety disorder, heart rate variability, longitudinal, perseverative cognition |
| الوصف: | Generalized anxiety disorder (GAD) is characterized by excessive worry, autonomic dysregulation and functional amygdala dysconnectivity, yet these illness markers have rarely been considered together, nor their interrelationship tested longitudinally. We hypothesized that an individual's capacity for emotion regulation predicts longer-term changes in amygdala functional connectivity, supporting the modification of GAD core symptoms. Sixteen patients with GAD (14 women) and individually matched controls were studied at two time points separated by 1 year. Resting-state fMRI data and concurrent measurement of vagally mediated heart rate variability were obtained before and after the induction of perseverative cognition. A greater rise in levels of worry following the induction predicted a stronger reduction in connectivity between right amygdala and ventromedial prefrontal cortex, and enhanced coupling between left amygdala and ventral tegmental area at follow-up. Similarly, amplified physiological responses to the induction predicted increased connectivity between right amygdala and thalamus. Longitudinal shifts in a distinct set of functional connectivity scores were associated with concomitant changes in GAD symptomatology over the course of the year. Results highlight the prognostic value of indices of emotional dysregulation and emphasize the integral role of the amygdala as a critical hub in functional neural circuitry underlying the progression of GAD symptomatology |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27369066; info:eu-repo/semantics/altIdentifier/wos/WOS:000388940000005; volume:11; issue:11; firstpage:1719; lastpage:1728; numberofpages:10; journal:SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE; http://hdl.handle.net/11573/927663Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84996848145; http://scan.oxfordjournals.orgTest/ |
| DOI: | 10.1093/scan/nsw091 |
| الإتاحة: | https://doi.org/10.1093/scan/nsw091Test http://hdl.handle.net/11573/927663Test http://scan.oxfordjournals.orgTest/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.94CC9490 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/scan/nsw091 |
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