التفاصيل البيبلوغرافية
| العنوان: |
A lysosomal regulatory circuit essential for the development and function of microglia. |
| المؤلفون: |
Iyer, Harini1, Shen, Kimberle1,2, Meireles, Ana M.1, Talbot, William S.1 william.talbot@stanford.edu |
| المصدر: |
Science Advances. 9/2/2022, Vol. 8 Issue 35, p1-17. 17p. |
| مصطلحات موضوعية: |
*MICROGLIA, *LYSOSOMES, *TRANSCRIPTION factors, *EMBRYOLOGY, *IMMUNOREGULATION, *DEVELOPMENTAL biology, *MICROPHTHALMIA-associated transcription factor, *CELL morphology |
| مستخلص: |
The article discusses research on the essentiality of the lysosomal regulatory circuit for macrophage development and function in vivo. Embryonic macrophages in rraga mutants show increased expression of lysosomal genes. It was found that by using ribonucleic acid sequencing, lysosomal transcription factors Tfeb and Tfe3 are required for activation of lysosomal target genes under conditions of stress but not for basal expression of lysosomal pathways. |
| قاعدة البيانات: |
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