التفاصيل البيبلوغرافية
| العنوان: |
Computational modelling in source space from scalp EEG to inform presurgical evaluation of epilepsy. |
| المؤلفون: |
Lopes, Marinho A.1,2,3,4 (AUTHOR) m.lopes@exeter.ac.uk, Junges, Leandro1,2,3 (AUTHOR), Tait, Luke1,2,3,5 (AUTHOR), Terry, John R.3,6,7 (AUTHOR), Abela, Eugenio8 (AUTHOR), Richardson, Mark P.3,8 (AUTHOR), Goodfellow, Marc1,2,3 (AUTHOR) |
| المصدر: |
Clinical Neurophysiology. Jan2020, Vol. 131 Issue 1, p225-234. 10p. |
| مصطلحات موضوعية: |
*EPILEPSY, *SCALP, *ELECTROENCEPHALOGRAPHY, *EPILEPSY surgery, *SEIZURES (Medicine) |
| مستخلص: |
• Computational modelling is combined with scalp EEG to assess epilepsy lateralization. • Our approach proved useful in informing lateralization in 12 out of 15 individuals studied. • The framework proposed may be used to aid deciding where to implant intracranial electrodes. The effectiveness of intracranial electroencephalography (iEEG) to inform epilepsy surgery depends on where iEEG electrodes are implanted. This decision is informed by noninvasive recording modalities such as scalp EEG. Herein we propose a framework to interrogate scalp EEG and determine epilepsy lateralization to aid in electrode implantation. We use eLORETA to map source activities from seizure epochs recorded from scalp EEG and consider 15 regions of interest (ROIs). Functional networks are then constructed using the phase-locking value and studied using a mathematical model. By removing different ROIs from the network and simulating their impact on the network's ability to generate seizures in silico , the framework provides predictions of epilepsy lateralization. We consider 15 individuals from the EPILEPSIAE database and study a total of 62 seizures. Results were assessed by taking into account actual intracranial implantations and surgical outcome. The framework provided potentially useful information regarding epilepsy lateralization in 12 out of the 15 individuals (p = 0.02 , binomial test). Our results show promise for the use of this framework to better interrogate scalp EEG to determine epilepsy lateralization. The framework may aid clinicians in the decision process to define where to implant electrodes for intracranial monitoring. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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