Highly Sensitive Electrochemical Sensor for Anticancer Drug by a Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite
| العنوان: | Highly Sensitive Electrochemical Sensor for Anticancer Drug by a Zirconia Nanoparticle-Decorated Reduced Graphene Oxide Nanocomposite |
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| المؤلفون: | Ankireddy Seshadri Reddy, Minyoung Yoon, M. Venu, Vinod Kumar Gupta, Yenugu Veera Manohara Reddy, Gajulapalli Madhavi, Sada Venkateswarlu |
| المصدر: | ACS Omega ACS Omega, Vol 3, Iss 11, Pp 14597-14605 (2018) |
| بيانات النشر: | American Chemical Society, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Materials science, Nanocomposite, Graphene, General Chemical Engineering, 010401 analytical chemistry, Oxide, Nanoparticle, Nanotechnology, 02 engineering and technology, General Chemistry, Conductivity, 021001 nanoscience & nanotechnology, 01 natural sciences, Article, 0104 chemical sciences, Electrochemical gas sensor, law.invention, Highly sensitive, lcsh:Chemistry, chemistry.chemical_compound, chemistry, lcsh:QD1-999, law, Cubic zirconia, 0210 nano-technology |
| الوصف: | Because of their large surface area and conductivity, some inorganic materials have emerged as good candidates for the trace-level detection of pharmaceutical drugs. In the present work, we demonstrate the detection of an anticancer drug (regorafenib, REG) by using an electrochemical sensor based on a nanocomposite material. We synthesized a zirconia-nanoparticle-decorated reduced graphene oxide composite (ZrO2/rGO) using a one-pot hydrothermal method. Reduction of the graphene oxide supports of the Zr2+ ions with hydrazine hydrate helped in preventing the agglomeration of the zirconia nanoparticles and in obtaining an excellent electrocatalytic response of the nanostructure ZrO2/rGO-based electrochemical sensor. Structural and morphological characterization of the nanostructure ZrO2/rGO was performed using various analytical methods. A novel regorafenib (REG) electrochemical sensor was fabricated by immobilizing the as-prepared nanostructure ZrO2/rGO on to a glassy carbon electrode (GCE). The resulting ZrO2/rGO/GCE could be used for the rapid and selective determination of REG in the presence of ascorbic acid and uric acid. The ZrO2/rGO/GCE showed a linear response for the REG analysis in the dynamic range 11–343 nM, with a remarkable lower detection limit and limit of quantifications of 17 and 59 nM, respectively. The newly developed sensor was used for the accurate determination of REG in both serum samples and pharmaceutical formulations, with satisfactory results. |
| اللغة: | English |
| تدمد: | 2470-1343 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7ee441e502f26af01b77fd5fa8b420Test http://europepmc.org/articles/PMC6289492Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....af7ee441e502f26af01b77fd5fa8b420 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24701343 |
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