التفاصيل البيبلوغرافية
| العنوان: |
Clinical Value of Detecting Anti-Mutated Citrullinated Vimentin, Anti-Cyclic Citrullinated Peptide, Red Cell Distribution Width and 25-Hydroxyvitamin D in the Diagnosis of Rheumatoid Arthritis. |
| المؤلفون: |
Tan, Liming, Gong, Yangyang, Zhang, Qian, Zhang, Haocheng, Lu, Xiaoxia, Huang, Huijin |
| المصدر: |
Laboratory Medicine; Jan2021, Vol. 52 Issue 1, p80-85, 6p |
| مصطلحات موضوعية: |
RHEUMATOID arthritis diagnosis, VITAMIN D metabolism, ERYTHROCYTES, ANALYSIS of variance, AUTOANTIBODIES, BIOMARKERS, ELECTROCHEMICAL analysis, ENZYME-linked immunosorbent assay, NONPARAMETRIC statistics, PEPTIDES, RESEARCH funding, VITAMIN D, RECEIVER operating characteristic curves, DATA analysis software, KRUSKAL-Wallis Test |
| مستخلص: |
Objectives To investigate the clinical value of detecting anti–mutated citrullinated vimentin (anti-MCV), anti-citrullinated peptide (anti-CCP), red-blood-cell distribution width (RDW), and 25-hydroxyvitamin D (25-[OH]D) in the diagnosis of rheumatoid arthritis (RA). Methods We enrolled 119 patients with RA, 114 control individuals without RA (disease controls), and 40 healthy controls in our study (Han Chinese). Anti-CCP and anti-MCV were detected by enzyme-linked immunosorbent assay (ELISA), 25-(OH)D was detected by electrochemical luminescence, and RDW was calculated by erythrocyte parameters detected via the electric resistance method. Results The serum levels of anti-CCP and anti-MCV in RA were higher than those in disease controls and healthy controls (P <.01). The areas under the curve (AUCs) of anti-MCV, anti-CCP, RDW, and 25-(OH)D were 0.857, 0.890, 0.611, and 0.569 respectively (P <.05). In various combinations of indicators, when RDW, 25-(OH)D, and anti-CCP; or RDW, 25-(OH)D, anti-CCP, and anti-MCV were connected in parallel, the sensitivity was the highest (all 94.1%). Also, when RDW, 25-(OH)D, anti-CCP, and anti-MCV were connected in series, the sensitivity was the lowest (13.4%). Conclusions Anti-CCP and anti-MCV are ideal indices for RA diagnosis. Also, in combination with RDW and 25-(OH)D, the diagnostic level will be improved, as well as the sensitivity and specificity, which is significant for the differential diagnosis of RA. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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