دورية أكاديمية
Two-year outcomes after percutaneous coronary intervention with drug-eluting stents or bare-metal stents in elderly patients with coronary artery disease.
| العنوان: | Two-year outcomes after percutaneous coronary intervention with drug-eluting stents or bare-metal stents in elderly patients with coronary artery disease. |
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| المؤلفون: | Lafont, Alexandre, Sinnaeve, Peter R, Cuisset, Thomas, Cook, Stéphane, Sideris, Giorgios, Kedev, Sasko, Carrie, Didier, Hovasse, Thomas, Garot, Philippe, El Mahmoud, Rami, Spaulding, Christian, Helft, Gérard, Diaz Fernandez, José F, Brugaletta, Salvatore, Pinar-Bermudez, Eduardo, Ferre, Josepa Mauri, Commeau, Philippe, Teiger, Emmanuel, Bogaerts, Kris, Sabate, Manel, Morice, Marie Claude, Varenne, Olivier, SENIOR investigators |
| سنة النشر: | 2020 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | PCI, bare metal stents, drug eluting stents, elderly patients, short DAPT, Aged, Coronary Artery Disease, Drug-Eluting Stents, Humans, Percutaneous Coronary Intervention, Prosthesis Design, Risk Factors, Stents, Treatment Outcome |
| الوصف: | Report the results at 2 years of the patients included in the SENIOR trial. Patients above 75 years of age represent a fast-growing population in the cathlab. In the SENIOR trial, patients treated by percutaneous coronary intervention (PCI) with drug eluting stent (DES) and a short duration of P2Y12 inhibitor (1 and 6 months for stable and unstable coronary syndromes, respectively) compared with bare metal stents (BMS) was associated with a 29% reduction in the rate of all-cause mortality, myocardial infarction (MI), stroke, and ischaemia-driven target lesion revascularization (ID-TLR) at 1 year. The results at 2 years are reported here. We randomly assigned 1,200 patients (596[50%] to the DES group and 604[50%] to the BMS group). At 2 years, the composite endpoint of all-cause mortality, MI, stroke and ID-TLR had occurred in 116 (20%) patients in the DES group and 131 (22%) patients in the BMS group (RR 0.90 [95%CI 0.72-1.13], p = .37). IDTLR occurred in 14 (2%) patients in the DES group and 41 (7%) patients in the BMS group (RR 0.35 [95%CI 0.16-0.60], p = .0002). Major bleedings (BARC 3-5) occurred in 27(5%) patients in both groups (RR 1.00, [95%CI 0.58-1.75], p = .99). Stent thrombosis rates were low and similar between DES and BMS (0.8 vs 1.3%, (RR 0.52 [95%CI 0.01-1.95], p = .27). Among elderly PCI patients, a strategy combining a DES together with a short duration of DAPT is associated with a reduction in revascularization up to 2 years compared with BMS with very few late events and without any increased in bleeding complications or stent thrombosis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1522-726X |
| العلاقة: | http://hdl.handle.net/10668/16060Test; https://lirias.kuleuven.be/bitstream/123456789/669028/2/SENIOR%202%20Years%20Final%20revised05062020.pdfTest |
| DOI: | 10.1002/ccd.29159 |
| الإتاحة: | https://doi.org/10.1002/ccd.29159Test http://hdl.handle.net/10668/16060Test https://lirias.kuleuven.be/bitstream/123456789/669028/2/SENIOR%202%20Years%20Final%20revised05062020.pdfTest |
| حقوق: | open access |
| رقم الانضمام: | edsbas.BF5E2668 |
| قاعدة البيانات: | BASE |
| تدمد: | 1522726X |
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| DOI: | 10.1002/ccd.29159 |