المؤلفون: Koji Miyamoto, Hiroki Takahashi, Takashi Noda, Satoshi Yasuda, Naoya Kataoka, Keiichi Ashikaga, Masahiko Takagi, Yoh Masue, Hiroshi Tada, Kengo Kusano, Kazuhiro Satomi, Kanae Hasegawa, Koji Fukuzawa

المصدر: Journal of Arrhythmia
Journal of Arrhythmia, Vol 36, Iss 3, Pp 449-455 (2020)

مصطلحات موضوعية: lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Radiofrequency ablation, cryoballoon, medicine.medical_treatment, Catheter ablation, RF ablation, Pulmonary vein, law.invention, law, Internal medicine, Clinical endpoint, Medicine, Ejection fraction, business.industry, Atrial fibrillation, Original Articles, AF, Ablation, medicine.disease, lcsh:RC666-701, Heart failure, Cardiology, Original Article, Cardiology and Cardiovascular Medicine, business

الوصف: Background Catheter ablation of atrial fibrillation (AF) is increasingly performed worldwide in patients with heart failure (HF). However, it has been recently emphasized that AF ablation in patients with HF is associated with increased risks of procedure‐related complications and mortality. There are little data about the differences in the efficacy and safety between cryoballoon (CB) and radiofrequency (RF) ablation of AF in patients with HF. Methods The CRABL‐HF study is designed as a prospective, multicenter, open‐label, controlled, and randomized clinical trial comparing the efficacy and safety of AF ablation between CB and RF ablation in patients with HF (LVEF ≤40%) (UMIN Clinical Trials Registry UMIN000032433). The CRABL‐HF study will consist of 110 patients at multicenter in Japan. The patients will be registered and randomly assigned to either the CB ablation or RF ablation group with a 1:1 allocation. The primary endpoint of this study is the occurrence of atrial tachyarrhythmias (ATs) at 1 year with a blanking period of 90 days after ablation. Key secondary endpoints are the success rate of the pulmonary vein isolation, total procedural time, left atrial dwelling time, total fluoroscopy time, radiation exposure, complication rate, composite of all‐cause mortality or HF hospitalizations, cardiovascular events, change in left ventricular ejection fraction, and change in quality of life. Results The results of this study are currently under investigation. Conclusion The CRABL‐HF study is being conducted to compare the efficacy and safety of catheter ablation of AF between CB and RF ablation in patients with HF.
There are little data about the differences in the efficacy and safety between cryoballoon (CB) and radiofrequency (RF) ablation of atrial fibrillation (AF) in patients with heart failure (HF). The CRABL‐HF study is being conducted to compare the efficacy and safety of catheter ablation of PAF between CB and RF ablation in patients with HF.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f119aec4bd21b8eb23d7287c8ae70e9dTest
https://doi.org/10.1002/joa3.12322Test

المؤلفون: Tomoo Harada, Michifumi Tokuda, Ikutaro Nakajima, Shiro Nakahara, Naoya Matsumoto, Teiichi Yamane, Ryuta Watanabe, Yoshinao Yazaki, Takayuki Otsuka, Yasuo Okumura, Takeshi Kato, AF Ablation Frontier Registry Investigators, Hidehira Fukaya, Wataru Shimizu, Naoto Otsuka, Hiroshi Hayashi, Ken Okumura, Yukihiko Momiyama, Noriko Nonoguchi, Shinya Suzuki, Junjiroh Koyama, Katsuaki Yokoyama, Masato Murakami, Kazumasa Sonoda, Masaru Inoue, Kazuhiro Satomi, Mitsuru Takami, Masahide Harada, Nobuhisa Hagiwara, Akio Hirata, Koji Kumagai, Kyoko Soejima, Yuji Wakamatsu, Yu-ki Iwasaki, Yuji Watari, Masaomi Kimura, Hidemori Hayashi, Koichiro Ejima, Koichi Nagashima, Kojiro Tanimoto

المصدر: Circulation journal : official journal of the Japanese Circulation Society. 86(2)

مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Renal function, Hemorrhage, Recurrence, Diabetes mellitus, Internal medicine, Atrial Fibrillation, medicine, Humans, Stroke, Aged, Retrospective Studies, Ejection fraction, Vascular disease, business.industry, Atrial fibrillation, General Medicine, medicine.disease, Ablation, Treatment Outcome, Quartile, Ischemic Attack, Transient, Cardiology, Catheter Ablation, Female, Cardiology and Cardiovascular Medicine, business

الوصف: BACKGROUND It is unclear whether there are differences in the clinical factors between atrial fibrillation (AF) recurrence and adverse clinical events (AEs), including stroke/transient ischemic attack (TIA), major bleeding, and death, after AF ablation.Methods and Results:We examined the data from a retrospective multicenter Japanese registry conducted at 24 cardiovascular centers between 2011 and 2017. Of the 3,451 patients (74.1% men; 63.3±10.3 years) who underwent AF ablation, 1,046 (30.3%) had AF recurrence and 224 (6.5%) suffered AEs (51 strokes/TIAs, 71 major bleeding events, and 36 deaths) over a median follow-up of 20.7 months. After multivariate adjustment, female sex, persistent and long-lasting persistent AF (vs. paroxysmal AF), and stepwise increased left atrial diameter (LAd) quartiles were significantly associated with post-ablation recurrences. A multivariate analysis revealed that an age ≥75 years (vs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29aba59ab866fd3cd7b5b8edcbdd61c4Test
https://pubmed.ncbi.nlm.nih.gov/34471068Test

المؤلفون: Yuko Nakazawa, Kazuaki Kaitani, Atsushi Kobori, Kaeko Hirai, Kazuhiro Satomi, Satoshi Shizuta, Koichi Inoue, Kengo Kusano, T Kurotobi, T Kimura, Naofumi Doi, Hajime Fujimoto, Hirosuke Yamaji, I Morishima, Masaki Naito

المصدر: European Heart Journal. 40

مصطلحات موضوعية: medicine.medical_specialty, Ejection fraction, business.industry, medicine.medical_treatment, Atrial fibrillation, Catheter ablation, medicine.disease, Internal medicine, Heart failure, cardiovascular system, Cardiology, Medicine, In patient, cardiovascular diseases, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology

الوصف: Introduction The presence of atrial fibrillation (AF) in patients with reduced left ventricular ejection fraction (LVEF) is associated with increased risks of mortality and hospitalization for heart failure (HF). Although prior studies reported that catheter ablation (CA) for AF in low LVEF patients reduced risks of all-cause mortality and HF hospitalization, the predictors of worsening HF after ablation has not been adequately evaluated. Purpose The purpose of this study was to investigate the impact of improvement in LVEF after AF ablation on the incidence of subsequent HF hospitalization in patients with low LVEF. Methods The Kansai Plus Atrial Fibrillation (KPAF) Registry is a multicenter registry enrolling 5,013 consecutive patients undergoing first-time ablation for AF. The current study population consisted of 1,031 patients with reduced LVEF of Results During the median follow-up of 1067 [879–1226] days, patients improved LVEF had lower rate of HF hospitalization, compared with those with unchanged and worsened LVEF (2.1%, 8.0%, and 21.5%, respectively, P Figure 1 Conclusion Among patients with reduced LVEF undergoing AF ablation, patients with subsequently improved LVEF in association with maintained sinus rhythm had markedly lower risk of HF hospitalization during follow-up as compared with those with unchanged or worsened LVEF.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::260d9e37378293917902a2fa5851b69dTest
https://doi.org/10.1093/eurheartj/ehz746.0593Test

المؤلفون: Toshihisa Anzai, Mitsuru Wada, Kohei Ishibashi, Takashi Noda, Satoshi Yasuda, Hideo Okamura, Shiro Kamakura, Takeshi Aiba, Yosuke Otsuka, Kengo Kusano, Ikutaro Nakajima, Hisao Ogawa, Kazuhiro Satomi, Teruo Noguchi, Yoshitaka Kimura, Koji Miyamoto

المصدر: JACC: Clinical Electrophysiology. 2:546-555

مصطلحات موضوعية: Heart transplantation, medicine.medical_specialty, Ejection fraction, business.industry, medicine.medical_treatment, 030204 cardiovascular system & hematology, medicine.disease, Ventricular tachycardia, Right ventricular cardiomyopathy, Sudden cardiac death, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Heart failure, Ventricular fibrillation, medicine, Cardiology, 030212 general & internal medicine, Risk factor, business

الوصف: Objectives The aim of this study was to assess sex-related differences in sporadic cases of arrhythmogenic right ventricular cardiomyopathy (ARVC). Background Previous studies have suggested male predominance in ARVC. However, the impact of sex on the heterogeneous clinical profile and prognosis of ARVC were not fully recognized. Methods The study population included 110 patients with ARVC who fulfilled the revised Task Force criteria (median age 48 years [interquartile range (IQR): 36 to 57 years]). All patients were sporadic cases without family history of ARVC. Male patients had a 3:1 predominance (75%). Ninety-seven patients (88%) were considered to have “definite” ARVC based on revised Task Force criteria. Results At the initial evaluation, there were no significant sex-related differences in age, 12-lead electrocardiogram findings, late potentials by signal-averaged electrocardiogram, left ventricular ejection fraction, or right ventricular ejection fraction. During a median follow-up of 10.0 years (IQR: 5.2 to 15.6 years), 18 patients died from cardiac causes. Kaplan-Meier analysis, considering patients’ lives since birth, revealed that male patients had a significantly higher risk of ventricular tachycardia/ventricular fibrillation than did female patients (56% vs. 90%, p = 0.02), whereas female patients had a significantly higher risk of heart failure (HF) death or heart transplantation (22% vs. 5%, p = 0.002). On multivariate Cox regression analysis, female sex was an independent risk factor for HF death or heart transplantation due to HF (hazard ratio: 6.29, 95% confidence interval: 1.29 to 40.2; p = 0.02). Conclusions Among patients with sporadic ARVC, men had a significantly higher risk of ventricular tachycardia/ventricular fibrillation, whereas women had a significantly higher risk of HF death or heart transplantation due to HF.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5371a9351fbc271cd8b9037f9eea70bcTest
https://doi.org/10.1016/j.jacep.2016.02.019Test

المؤلفون: Soichiro Kitamura, Hisao Ogawa, Toshihisa Anzai, Hajime Ohgushi, Noritoshi Nagaya, Teruo Noguchi, Wataru Shimizu, Kazuhiro Satomi, Takeshi Yagyu, Takeshi Nakatani, Satoshi Yasuda, Kenji Kangawa, Kaori Doi, Kengo Kusano

المصدر: Circulation journal : official journal of the Japanese Circulation Society. 83(7)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Cardiac Catheterization, medicine.medical_treatment, Cardiomyopathy, 030204 cardiovascular system & hematology, Mesenchymal Stem Cell Transplantation, Intracardiac injection, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Adverse effect, Heart transplantation, Heart Failure, Ischemic cardiomyopathy, Ejection fraction, business.industry, General Medicine, Middle Aged, medicine.disease, Transplantation, Survival Rate, Heart failure, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Cardiomyopathies, Follow-Up Studies

الوصف: Background Mesenchymal stem cells (MSCs), which have the potential to differentiate into cardiomyocytes or vascular endothelial cells, have been used clinically as therapy for cardiomyopathy. In this study, we aimed to evaluate the long-term follow-up results.Methods and Results:We studied 8 patients with symptomatic heart failure (HF) on guideline-directed therapy (ischemic cardiomyopathy, n=3; nonischemic cardiomyopathy, n=5) who underwent intracardiac MSC transplantation using a catheter-based injection method between May 2004 and April 2006. Major adverse events and hospitalizations were investigated up to 10 years afterward. Compared with baseline, there were no significant differences in B-type natriuretic peptide (BNP) (from 211 to 173 pg/mL), left ventricular ejection fraction (LVEF) (from 24% to 26%), and peak oxygen uptake (from 16.5 to 19.2 mL/min/kg) at 2 months. During the follow-up period, no patients experienced serious adverse events such as arrhythmias. Three patients died of pneumonia in the 1st year, liver cancer in the 6th year, and HF in the 7th year. Of the remaining 5 patients, 3 patients were hospitalized for exacerbated HF, 1 of whom required heart transplantation in the 2nd year; 2 patients survived for 10 years without worsening HF. Conclusions The results of this exploratory study of intracardiac MSCs administration suggest further research regarding the feasibility and efficacy is warranted.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac6015e82add9052b24b5e8e2ad8dceTest
https://pubmed.ncbi.nlm.nih.gov/31142705Test

المؤلفون: Wataru Shimizu, Hideo Okamura, Takeshi Aiba, Toshihisa Anzai, Koji Miyamoto, Shiro Kamakura, Mitsuru Wada, Teruo Noguchi, Takashi Noda, Kengo Kusano, Satoshi Yasuda, Ikutaro Nakajima, Kohei Ishibashi, Kazuhiro Satomi, Hisao Ogawa

المصدر: Heart and Vessels. 31:1337-1346

مصطلحات موضوعية: Male, medicine.medical_specialty, Heart Ventricles, medicine.medical_treatment, Myocardial Ischemia, Cardiomyopathy, Catheter ablation, 030204 cardiovascular system & hematology, Ventricular tachycardia, Ventricular Function, Left, Cicatrix, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, parasitic diseases, medicine, Humans, 030212 general & internal medicine, Endocardium, Aged, Retrospective Studies, Ejection fraction, Ischemic cardiomyopathy, business.industry, Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Middle Aged, medicine.disease, Catheter Ablation, Tachycardia, Ventricular, Cardiology, Female, Cardiomyopathies, Electrophysiologic Techniques, Cardiac, Cardiology and Cardiovascular Medicine, business, Pericardium

الوصف: Patients with ischemic and non-ischemic cardiomyopathy often have substrate for ventricular tachycardia (VT) in the endocardium (ENDO), epicardium (EPI), and/or intramural. Although it has been reported that the ENDO unipolar (UNI) voltage map is useful in detecting EPI substrate, its feasibility to detect intramural scarring and its usefulness in radiofrequency catheter ablation (RFCA) remain unclear. To assess the relationship between the left ventricle (LV) ENDO UNI voltage map and the LV EPI bipolar (BIP) voltage map, and to determine the usefulness of the ENDO UNI voltage map to guide RFCA for VT in patients with cardiomyopathy undergoing combined ENDO- and EPI RFCA. Eleven patients with VT undergoing detailed ENDO and EPI electroanatomical mapping of the LV were included (mean age 59 ± 11 years, 9 men). We assessed the value of the LV ENDO UNI voltage map in identifying EPI and/or intramural substrate in these 11 patients with non-ischemic or ischemic cardiomyopathy. The underlying heart disease was dilated cardiomyopathy in 4 patients, cardiac sarcoidosis in 3, hypertrophic cardiomyopathy in 2, and ischemic heart disease in 2 patients. The mean LV ejection fraction was 24 ± 7 %. The low voltage zone (LVZ) was defined as

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd84dce3f0c1b159f28764e4114f8a7dTest
https://doi.org/10.1007/s00380-015-0732-7Test

المؤلفون: Wataru Shimizu, Kengo Kusano, Koji Miyamoto, Kazuhiro Satomi, Hiroshi Kawakami, Takashi Noda

المصدر: HeartRhythm Case Reports
HeartRhythm Case Reports, Vol 1, Iss 3, Pp 110-113 (2015)

مصطلحات موضوعية: medicine.medical_specialty, PM, papillary muscle, medicine.medical_treatment, Case Report, Catheter ablation, Ventricular tachycardia, Chordae tendineae, Intracardiac injection, CMR, cardiac magnetic resonance, Cardiac magnetic resonance imaging, Internal medicine, LVEF, left ventricular ejection fraction, VT, ventricular tachycardia, Papillary muscle, medicine, Diseases of the circulatory (Cardiovascular) system, RF, radiofrequency, PPM, posterior papillary muscle, Ejection fraction, medicine.diagnostic_test, business.industry, VA, ventricular arrhythmia, Three dimensional echocardiography, medicine.disease, LV, left ventricle, medicine.anatomical_structure, RC666-701, Intracardiac echocardiography, Cardiology, Cardiology and Cardiovascular Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5baa74bb3073e7afa2958bd8a323a0c3Test
https://doi.org/10.1016/j.hrcr.2014.12.011Test

المؤلفون: Nobukazu Ishizaka, Hideaki Kanzaki, Yasushi Kitaura, Takashi Noda, Masafumi Kitakaze, Wataru Shimizu, Shiro Kamakura, Kazuhiro Satomi

المصدر: Internal Medicine. 54:1329-1335

مصطلحات موضوعية: Male, Acute effects, medicine.medical_specialty, Heart Ventricles, medicine.medical_treatment, Diastole, Cardiac resynchronization therapy, Ventricular Function, Left, Contractility, QRS complex, Heart Conduction System, Internal medicine, Internal Medicine, medicine, Humans, In patient, Heart Failure, Ejection fraction, business.industry, Cardiac Pacing, Artificial, General Medicine, Middle Aged, medicine.disease, Heart failure, cardiovascular system, Cardiology, Female, business

الوصف: OBJECTIVE Upgrading to biventricular (BiV) pacing benefits heart failure patients with right ventricular (RV) apical pacing. However, the impact of switching from RV apical pacing to BiV pacing on the left ventricular (LV) function accompanied by changes in the QRS duration remains unknown. We aimed to investigate the effects of BiV pacing in heart failure patients under RV apical pacing. METHODS In 37 patients with heart failure (LV ejection fraction: 22±9%), the maximum rate of LV pressure rise (LV dP/dtmax) and time constant of LV relaxation (tau) were determined in order to assess LV contractility and diastolic relaxation, respectively, under RV apical pacing and BiV pacing. Switching from RV pacing to BiV pacing, the QRS duration was shortened from 209±42 to 162±28 ms (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9648feac11ca0b8ab1d6c8130606e5Test
https://doi.org/10.2169/internalmedicine.54.3081Test

المؤلفون: Mitsuru Wada, Takeshi Aiba, Toshihisa Anzai, Takashi Noda, Satoshi Nagase, Teruo Noguchi, Kazuhiro Satomi, Hideo Okamura, Kohei Ishibashi, Yuko Wada, Hiroaki Shimokawa, Satoshi Yasuda, Seiko Ohno, Koji Miyamoto, Yoshitaka Kimura, Minoru Horie, Shiro Kamakura, Kengo Kusano, Taka aki Matsuyama, Tsukasa Kamakura, Yuko Inoue, Wataru Shimizu, Yosuke Otsuka

المصدر: International journal of cardiology. 241

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, 030204 cardiovascular system & hematology, Right ventricular cardiomyopathy, Sudden cardiac death, Cohort Studies, 03 medical and health sciences, Electrocardiography, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, 030212 general & internal medicine, PR interval, Risk factor, Arrhythmogenic Right Ventricular Dysplasia, Retrospective Studies, Heart Failure, Ejection fraction, business.industry, Stroke Volume, Middle Aged, Implantable cardioverter-defibrillator, medicine.disease, Hospitalization, First-degree atrioventricular block, Echocardiography, Heart failure, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies

الوصف: We previously demonstrated that heart failure (HF) was one of the major causes of death in arrhythmogenic right ventricular cardiomyopathy (ARVC). The purpose of this study was to elucidate the clinical impact and risk factors of HF in patients with ARVC.We evaluated cardiac adverse outcomes including HF in 113 consecutive patients with ARVC (85 men, mean age: 44±15years). During a median follow-up of 10.0years (interquartile range: 5.2 to 15.7years), 29 patients (26%) were hospitalized for progressive HF. The patients with one or more episodes of HF hospitalization had about a 10-fold increased incidence of cardiac death (14/29 [48%] vs. 4/84 [4.7%], p0.0001). Left ventricular ejection fraction (LVEF) and right ventricular ejection fraction (RVEF) were significantly lower in the patients with HF hospitalization compared to the patients without HF hospitalization (LVEF, 45±15 vs. 54±13%, p=0.001; RVEF, 26±10 vs. 33±11%, p=0.003, respectively). Regarding the ECG findings, the prevalence of first-degree atrioventricular block (AVB, PR interval200ms) and epsilon waves were significantly higher in patients with HF hospitalization than those without HF hospitalization (first-degree AVB, 14/29 [48%] vs. 11/84 [13%], p0.0001; epsilon waves, 10/29 [34%] vs. 12/84 [14%], p=0.02). In multivariate analysis, first-degree AVB at baseline was the strongest independent risk factor for HF hospitalization in patients with ARVC (hazard ratio 4.24, 95% confidence interval 1.79-10.47, p=0.0011).HF hospitalization has a significant relation with malignant clinical course in ARVC patients. First-degree AVB was an independent determinant for increased risk of HF hospitalization.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8194ddbf422e71341e593fbdc5dfaec5Test
https://pubmed.ncbi.nlm.nih.gov/28465114Test

المؤلفون: Kazuhiro Suyama, Hideo Okamura, Teruki Yokoyama, Hiro Kawata, Ikutaro Nakajima, Takeshi Aiba, Hisaki Makimoto, Shiro Kamakura, Takashi Noda, Wataru Shimizu, Kazuhiro Satomi, Naohiko Aihara, Kenichiro Yamagata, Yuko Yamada, Atsushi Doi

المصدر: Japanese Journal of Electrocardiology. 30:385-394

مصطلحات موضوعية: medicine.medical_specialty, Electrophysiology, Ejection fraction, business.industry, Internal medicine, medicine, Cardiology, In patient, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3bc943e513ae57cd71e552de9172c36cTest
https://doi.org/10.5105/jse.30.385Test