دورية أكاديمية
Efficacy and safety of flexible versus rigid endoscopic third ventriculostomy in pediatric and adult populations: a systematic review and meta-analysis
| العنوان: | Efficacy and safety of flexible versus rigid endoscopic third ventriculostomy in pediatric and adult populations: a systematic review and meta-analysis |
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| المؤلفون: | Boaro, Alessandro, Mahadik, Bhargavi, Petrillo, Anthony, Siddi, Francesca, Devi, Sharmila, Chawla, Shreya, Abunimer, Abdullah M, Feletti, Alberto, Fiorindi, Alessandro, Longatti, Pierluigi, Sala, Francesco, Smith, Timothy R, Mekary, Rania A |
| المساهمون: | Boaro, Alessandro, Mahadik, Bhargavi, Petrillo, Anthony, Siddi, Francesca, Devi, Sharmila, Chawla, Shreya, Abunimer, Abdullah M, Feletti, Alberto, Fiorindi, Alessandro, Longatti, Pierluigi, Sala, Francesco, Smith, Timothy R, Mekary, Rania A |
| سنة النشر: | 2022 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | complications, efficacy, endoscopic third ventriculostomy, flexible neuroendoscopy, hydrocephalus, rigid neuroendoscopy |
| الوصف: | Endoscopic third ventriculostomy (ETV) is a well-established surgical procedure for hydrocephalus treatment, but there is sparse evidence on the optimal choice between flexible and rigid approaches. A meta-analysis was conducted to compare efficacy and safety profiles of both techniques in pediatrics and adults. A comprehensive search was conducted on PubMED, EMBASE, and Cochrane until 11/10/2019. Efficacy was evaluated comparing incidence of ETV failure, while safety was defined by the incidence of perioperative complications, intraoperative bleedings, and deaths. Random-effects models were used to pool the incidence. Out of 1365 studies, 46 case series were meta-analyzed, yielding 821 patients who underwent flexible ETV and 2918 who underwent rigid ETV, with an age range of [5days-87years]. Although flexible ETV had a higher incidence of failure in adults (flexible: 54%, 95%CI: 22-82% vs rigid: 20%, 95%CI: 22-82%) possibly due to confounding due to etiology in adults treated with flexible, a smaller difference was seen in pediatrics (flexible: 36%, pediatric: 32%). Safety profiles were acceptable for both techniques, with a certain degree of variability for complications (flexible 2%, rigid 18%) and death (flexible 1%, rigid 3%) in pediatrics as well as complications (rigid 9%, flexible 13%), death (flexible 4%, rigid 6%) and intra-operative bleeding events (rigid 6%, flexible 8%) in adults. No clear superiority in efficacy could be depicted between flexible and rigid ETV for hydrocephalus treatment. Safety profiles varied by age but were acceptable for both techniques. Well-designed comparative studies are needed to assess the optimal endoscopic treatment option for hydrocephalus. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34173114; info:eu-repo/semantics/altIdentifier/wos/WOS:000666999500002; volume:45; issue:1; firstpage:199; lastpage:216; numberofpages:18; journal:NEUROSURGICAL REVIEW; http://hdl.handle.net/11562/1045423Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85108827259; https://doi.org/10.1007/s10143-021-01590-6Test |
| DOI: | 10.1007/s10143-021-01590-6 |
| الإتاحة: | https://doi.org/10.1007/s10143-021-01590-6Test http://hdl.handle.net/11562/1045423Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5A5F9F96 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10143-021-01590-6 |
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