المؤلفون: Lonny R. Levin, Makoto Fushimi, Jochen Buck, David J. Huggins, Melanie Balbach, Clemens Steegborn, Peter T. Meinke

المصدر: Biology of Reproduction

مصطلحات موضوعية: 0301 basic medicine, capacitation, male contraception, media_common.quotation_subject, Fertility, Biology, Bioinformatics, soluble adenylyl cyclase, 03 medical and health sciences, 0302 clinical medicine, Contraceptive Agents, On demand, Drug Discovery, Humans, education, media_common, education.field_of_study, Drug discovery, Mechanism (biology), Cell Biology, General Medicine, Soluble adenylyl cyclase, Contraceptive Special Issue, 030104 developmental biology, Reproductive Medicine, Lead, Male fertility, AcademicSubjects/MED00773, 030217 neurology & neurosurgery, Adenylyl Cyclases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a8fa47c71526e351dd32340b3be292Test
http://europepmc.org/articles/PMC7401349Test

المؤلفون: Koerschen Hg, Luis Alvarez, Kambach C, Jochen Buck, Seifert R, Hussein Hamzeh, Ulrich Benjamin Kaupp, Mayako Michino, Clemens Steegborn, Sato A, René Pascal, Navpreet Kaur, W. Boenigk, Jennings A, Lonny R. Levin, Struenker T

مصطلحات موضوعية: education.field_of_study, biology, Chemistry, Motility, Chemotaxis, Soluble adenylyl cyclase, Sperm, Sexual reproduction, Cell biology, biology.animal, External fertilization, education, Sea urchin, Sperm motility

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f12fc511669b1931b6759302c35a1a8dTest
https://doi.org/10.1101/2021.06.18.448929Test

المؤلفون: Lonny R. Levin, Clemens Steegborn, Shakarr V. Wiggins, Jochen Buck

المصدر: Pharmacology & Therapeutics. 190:173-186

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, education.field_of_study, G protein, Lipid microdomain, Phosphodiesterase, Soluble adenylyl cyclase, ADCY10, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, Cyclic nucleotide, 030104 developmental biology, chemistry, Second messenger system, Pharmacology (medical), education, Adenosine triphosphate

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c70adb6fa21c24b903a7b11dcc8d1a13Test
https://doi.org/10.1016/j.pharmthera.2018.05.008Test

المؤلفون: Ivo F Machado, Anabela P. Rolo, David A. Sinclair, Clemens Steegborn, João A. Amorim, Ana C. Castela, Carlos M. Palmeira, João S. Teodoro

المصدر: International Journal of Molecular Sciences, Vol 21, Iss 4896, p 4896 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 14

مصطلحات موضوعية: Male, Premedication, Mitochondria, Liver, Mitochondrion, Pharmacology, sirtuin 3, Adenylyl cyclase, soluble adenylyl cyclase, lcsh:Chemistry, Random Allocation, chemistry.chemical_compound, Hepatic Artery, Inducer, Phosphorylation, lcsh:QH301-705.5, Spectroscopy, Membrane Potential, Mitochondrial, education.field_of_study, biology, Portal Vein, General Medicine, Constriction, Computer Science Applications, Adenosine Diphosphate, mitochondria, Reperfusion Injury, Sirtuin, medicine.symptom, Adenylyl Cyclases, SIRT3, Thiophenes, liver, Article, Catalysis, Inorganic Chemistry, Hormesis, Oxygen Consumption, medicine, Animals, Rats, Wistar, Physical and Theoretical Chemistry, education, Molecular Biology, Organic Chemistry, Organ dysfunction, Soluble adenylyl cyclase, ischemia/reperfusion, LRE1, Rats, Disease Models, Animal, Pyrimidines, Gene Expression Regulation, Solubility, chemistry, lcsh:Biology (General), lcsh:QD1-999, Adenylyl Cyclase Inhibitors, biology.protein, NAD+ kinase, Reactive Oxygen Species, Liver Failure

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c82444c51bb5f79d9c50db8728a7816Test
https://www.mdpi.com/1422-0067/21/14/4896Test

المؤلفون: Antonio Alvau, Clemens Steegborn, Joop van den Heuvel, Giovanni Manfredi, Federica Valsecchi, Hannes Buck, Jonathan H. Zippin, Anatoly A. Starkov, J. Fraser Glickman, Lonny R. Levin, Felipe Navarrete, Carolina Adura, Jochen Buck, Silke Kleinboelting, Lavoisier Ramos-Espiritu, Pablo E. Visconti

المساهمون: Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.

المصدر: Nature chemical biology

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Allosteric regulation, Thiophenes, Cyclase, Article, ADCY10, Adenylyl cyclase, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Allosteric Regulation, Humans, education, Molecular Biology, education.field_of_study, Dose-Response Relationship, Drug, Molecular Structure, Activator (genetics), Chemistry, ADCY9, Cell Biology, Soluble adenylyl cyclase, Pyrimidines, 030104 developmental biology, Solubility, Biochemistry, Adenylyl Cyclase Inhibitors, Second messenger system, Adenylyl Cyclases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5935987d11399741ba4088204b3a515bTest
https://doi.org/10.1038/nchembio.2151Test

المؤلفون: Clemens Steegborn

المصدر: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1842(12):2535-2547

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Biology, Isozyme, Heterotrimeric G protein, cAMP, medicine, Humans, education, Receptor, Molecular Biology, chemistry.chemical_classification, education.field_of_study, Membrane Proteins, Soluble adenylyl cyclase, Adenosine, Transmembrane protein, Signaling, Cell biology, Bicarbonate, Metabolic sensor, Enzyme, Biochemistry, chemistry, Second messenger system, Molecular Medicine, Calcium, medicine.drug, Adenylyl Cyclases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efd970011a63e43292244907747f6fdTest

المؤلفون: Clemens Steegborn, Michael Weyand, Lonny R. Levin, Sébastien Moniot, Ana Diaz, Jochen Buck, Silke Kleinboelting, Joop van den Heuvel

المصدر: Proceedings of the National Academy of Sciences. 111:3727-3732

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Plasma protein binding, Substrate analog, Catalysis, Enzyme activator, chemistry.chemical_compound, Protein structure, Humans, Cloning, Molecular, education, chemistry.chemical_classification, education.field_of_study, Multidisciplinary, biology, Chemistry, Active site, Biological Sciences, Soluble adenylyl cyclase, Enzyme Activation, Sodium Bicarbonate, Enzyme, Biochemistry, embryonic structures, Second messenger system, biology.protein, Crystallization, Adenylyl Cyclases, Protein Binding, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690ca494b16411c844099890f582cd9bTest
https://doi.org/10.1073/pnas.1322778111Test

المؤلفون: Clemens Steegborn, Laureen Colis, J. Fraser Glickman, Jochen Buck, Lavoisier Ramos-Espiritu, Hannes Buck, Joop van den Heuvel, Silke Kleinboelting, Lonny R. Levin

المساهمون: Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.

مصطلحات موضوعية: 0301 basic medicine, G protein, Allosteric regulation, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Adenosine Triphosphate, Allosteric Regulation, Catalytic Domain, Humans, education, Molecular Biology, education.field_of_study, biology, Activator (genetics), Active site, Cell Biology, Soluble adenylyl cyclase, Transmembrane protein, Bicarbonates, 030104 developmental biology, Allosteric enzyme, chemistry, Enzymology, biology.protein, Bithionol, Adenosine triphosphate, Adenylyl Cyclases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee22c8c1a9c743c44e29e1d713f0eee9Test
https://hdl.handle.net/10033/620904Test

المؤلفون: Jochen Buck, Michael Russwurm, Clemens Steegborn, Rebeca Acín-Pérez, Lonny R. Levin, Kathrin Günnewig, Melanie Gertz, Georg Zoidl, Joachim Rassow, Lavoisier S. Ramos, Giovanni Manfredi

المصدر: Journal of Biological Chemistry. 286:30423-30432

مصطلحات موضوعية: Gene isoform, Cell Respiration, Green Fluorescent Proteins, Respiratory chain, Mitochondrion, Biology, Biochemistry, Animals, Humans, Protein Isoforms, education, Cyclic GMP, Molecular Biology, education.field_of_study, Microscopy, Confocal, Brain, Phosphodiesterase, Cell Biology, Soluble adenylyl cyclase, Cyclic Nucleotide Phosphodiesterases, Type 2, Mitochondria, Protein Structure, Tertiary, Rats, Cell biology, Liver, 3',5'-Cyclic-AMP Phosphodiesterases, Mitochondrial matrix, Second messenger system, Endopeptidase K, Signal transduction, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a09f18f35457c3d5a0de626b514ef0Test
https://doi.org/10.1074/jbc.m111.266379Test

المؤلفون: Clemens Steegborn, Michael Weyand, Christian Kambach, Silke Kleinboelting, Martina Leipelt, Joop van den Heuvel

المصدر: Acta Crystallographica Section F Structural Biology Communications. 70:467-469

مصطلحات موضوعية: Models, Molecular, Protein Conformation, Stereochemistry, Biophysics, Crystallography, X-Ray, Biochemistry, law.invention, Adenylyl cyclase, chemistry.chemical_compound, Protein structure, Structural Biology, law, Catalytic Domain, Genetics, Humans, Cloning, Molecular, Binding site, Crystallization, education, education.field_of_study, Binding Sites, Chemistry, Resolution (electron density), Soluble adenylyl cyclase, Condensed Matter Physics, Recombinant Proteins, Crystallography, Crystallization Communications, X-ray crystallography, Second messenger system, Adenylyl Cyclases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c75065b4cbe202046d792d341a4d77Test
https://doi.org/10.1107/s2053230x14004014Test