Impact of obesity on diagnosis and treatment of breast cancer
| العنوان: | Impact of obesity on diagnosis and treatment of breast cancer |
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| المؤلفون: | Elisabetta Rapiti, Georges Vlastos, M. Castiglione, Silvia Ess, Helena M. Verkooijen, Massimo Usel, Mafalda Burri, Carole Deglise, Pierre O. Chappuis, Christine Bouchardy, Michela Ceschi, Isabelle Neyroud-Caspar |
| المصدر: | Breast Cancer Research and Treatment, Vol. 120, No 1 (2010) pp. 185-93 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Population, Breast Neoplasms, Body Mass Index, Breast cancer, Lymphatic Metastasis/diagnosis, medicine, Humans, Obesity, education, ddc:613, Aged, Neoplasm Staging, ddc:616, education.field_of_study, ddc:618, Obstetrics, business.industry, Cancer, Breast Neoplasms/complications/diagnosis/therapy, Odds ratio, Length of Stay, Middle Aged, medicine.disease, Surgery, Oncology, Lymphatic Metastasis, Female, Breast disease, Obesity/complications, Underweight, medicine.symptom, business, Body mass index |
| الوصف: | In this population-based study, we evaluated the impact of obesity on presentation, diagnosis and treatment of breast cancer. Among all women diagnosed with invasive breast cancer in the canton Geneva (Switzerland) between 2003 and 2005, we identified those with information on body mass index (BMI) and categorized them into normal/underweight (BMI or =- or =30 kg/m(2)) women. Using multivariate logistic regression, we compared tumour, diagnosis and treatment characteristics between groups. Obese women presented significantly more often with stage III-IV disease (adjusted odds ratio [OR(adj)]: 1.8, 95% CI: 1.0-3.3). Tumours > or =1 cm and pN2-N3 lymph nodes were significantly more often impalpable in obese than in normal/underweight patients (OR(adj) 2.4, [1.1-5.3] and OR(adj) 5.1, [1.0-25.4], respectively). Obese women were less likely to have undergone ultrasound (OR(adj) 0.5, [0.3-0.9]) and MRI (OR(adj) 0.3, [0.1-0.6]) and were at increased risk of prolonged hospital stay (OR(adj) 4.7, [2.0-10.9]). This study finds important diagnostic and therapeutic differences between obese and lean women, which may impair survival of obese women with breast cancer. Specific strategies are needed to optimize the care of obese women with or at risk of breast cancer. |
| تدمد: | 1573-7217 0167-6806 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc20cfeab98000d5812be0e0fc24615Test https://doi.org/10.1007/s10549-009-0459-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8cc20cfeab98000d5812be0e0fc24615 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737217 01676806 |
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