التفاصيل البيبلوغرافية
| العنوان: |
M85. Age-Related Effect of Vitamin D on Hippocampus Volume in Schizophrenia and Bipolar Disorder |
| المؤلفون: |
Gurholt, Tiril Pedersen, Nerhus, Mari |
| بيانات النشر: |
Oxford University Press |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
Abstracts, anthro-bio, edu |
| الوصف: |
Background: Schizophrenia and bipolar spectrum disorders (SZBD) are devastating mental disorders with unknown cause and suboptimal treatment. Vitamin D (25OHD) deficiency during development is considered a risk factor for developing schizophrenia and neonatal 25OHD status has been linked to the disorder (McGrath et al. 2010. Schizophr Bull, 36). Psychosis patients more often have sub-optimal 25OHD status and low S-25OHD has been linked to depression and negative symptoms (Nerhus et al. 2016. Schizophr Res). Vitamin D receptors and the 1alpha -hydroxylase enzyme are found in human hippocampus tissue (Eyles et al. 2005. J Chem Neuroanat, 29). Recent reports have shown positive correlation between the right hippocampus and S-25OHD (Shivakumar et al. 2015. Psychiatry Res, 233) as well as age-related hippocampus volume decline (Pujol et al. 2014. Br J Psychiatry, 205) in schizophrenia. To examine a potential role of S-25OHD in age-related hippocampus decline, SZBD patients and healthy controls (HC) were investigated for S-25OHD and hippocampus volume across the age range. |
| نوع الوثيقة: |
text |
| اللغة: |
English |
| العلاقة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475997Test/ |
| الإتاحة: |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475997Test/ |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.B36D94B0 |
| قاعدة البيانات: |
BASE |
