التفاصيل البيبلوغرافية
| العنوان: |
Post-extrasystolic potentiation as a predictor of premature ventricular contraction-cardiomyopathy in an animal model. |
| المؤلفون: |
Kowlgi, Gurukripa N, Ramirez, Rafael J, Kaszala, Karoly, Joslyn, Martha, Koneru, Jayanthi N, Ellenbogen, Kenneth A, Tan, Alex Y, Huizar, Jose F |
| المصدر: |
EP: Europace; May2020, Vol. 22 Issue 5, p813-820, 8p |
| مصطلحات موضوعية: |
ARRHYTHMIA diagnosis, ECHOCARDIOGRAPHY, LEFT heart ventricle, RESEARCH, CARDIOMYOPATHIES, ANIMAL experimentation, RESEARCH methodology, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RESEARCH funding, HEART physiology, STROKE volume (Cardiac output), DOGS |
| مستخلص: |
Aims: High premature ventricular contractions (PVCs) burden does not always predict the development of PVC-cardiomyopathy (CM). We sought to evaluate post-extrasystolic potentiation (PESP) of left ventricular ejection fraction (LVEF) to predict the severity of PVC-CM in an animal model.Methods and Results: Right ventricular apical bigeminal PVCs were introduced for 12 weeks in 11 canines to induce PVC-CM. Echocardiograms were performed to obtain LVEF without ectopy (Echo-1) and during PVCs (200 and 350 ms coupling intervals, Echo-2, and Echo-3, respectively), and premature atrial contractions (PACs) (Echo-4) at baseline and after 12 weeks of bigeminal PVCs. PESP was calculated as delta-LVEF between the sinus beat post-ectopy LVEF (Echo-2, -3, and -4, respectively) and LVEF without PVC (Echo-1) at baseline and 12 weeks of high PVC burden. A hyperdynamic LV function (LVEF > 70%) was noted in all animals only with early-coupled PVCs (LVEF at 200 ms: 74.4 ± 6%) at baseline. While PVC PESP at 200 ms had a strong significant correlation with the final 12-week LVEF (R = 0.8, P = 0.003), PVC PESP at 350 ms and PAC PESP had a positive but non-significant correlation (R = 0.53, P = 0.09, and R = 0.29, P = 0.34, respectively). Premature ventricular contraction PESP at 350 ms was significantly higher after PVC-CM had developed (delta-LVEF baseline 2.7 ± 2.9% vs. 12 weeks 18.6 ± 12.3% P < 0.001).Conclusion: Bigeminal early-coupled PVCs cause hyperdynamic left ventricular function in the structurally normal canine heart due to PESP. The degree of PESP at baseline is inversely proportional to the PVC-CM severity at 12 weeks and maybe a predictor of PVC-CM as it may assess the myocardial adaptation reserve to PVCs. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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