التفاصيل البيبلوغرافية
| العنوان: |
Effects of early life stress during stress hyporesponsive period (SHRP) on anxiety and curiosity in adolescent rats. |
| المؤلفون: |
Sharma, Shruthi S., Srinivas Bharath, M. M., Doreswamy, Yoganarasimha, Laxmi, T. Rao |
| المصدر: |
Experimental Brain Research; Apr2022, Vol. 240 Issue 4, p1127-1138, 12p |
| مصطلحات موضوعية: |
LIFE change events, CURIOSITY, IMMOBILIZATION stress, RISK-taking behavior, SPRAGUE Dawley rats, ANIMAL behavior, ANXIETY |
| مستخلص: |
Repeated exposure to adverse experiences in early life, termed Early Life Stress (ELS), can increase anxiety disorders later in life. Anxiety is directly associated with curiosity, a form of intrinsic drive state associated with increased novelty-seeking behaviour and risk taking for challenging opportunities and could probably modulate learning and memory. In humans, elevated curiosity during adolescence tends to elicit increased exploration, novelty seeking, high risk-taking behaviour and heightened emotionality. Such behaviours are beneficial in maintaining social skills and cognitive functions later in life. We investigated whether ELS-induced anxiety impacts curiosity-like behaviour at adolescence in an animal model. ELS was induced by subjecting Sprague Dawley rat pups to maternal separation and isolation (MS) stress during the stress hyporesponsive period (SHRP) from post-natal days (PND) 4-PND 14. This rat model was tested for anxiety, spontaneous exploratory behaviour and curiosity-like behaviour in a custom-designed arena during adolescence (PND 30–45). ELS-induced changes in the stress were confirmed by corticosterone, while, basal dopamine level was estimated to understand the neurochemical basis of MS stress-induced changes in curiosity. We observed an increase in the levels of anxiety and intrinsic drive state such as curiosity-like behaviour, which was associated with elevated plasma corticosterone and dopamine in MS animals during adolescence suggesting the impact of ELS during SHRP on adolescent behaviour. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
