The expression of the distal dystrophin isoforms DP140 and DP71 in the human epileptic hippocampus in relation tot cognitive functioning
| العنوان: | The expression of the distal dystrophin isoforms DP140 and DP71 in the human epileptic hippocampus in relation tot cognitive functioning |
|---|---|
| المؤلفون: | Olaf E. M. G. Schijns, Marlien W. Aalbers, Marc P. H. Hendriks, Govert Hoogland, Johan S.H. Vles, Ruben G. F. Hendriksen, Rutger J. Slegers |
| المساهمون: | MUMC+: MA Niet Med Staf Neurochirurgie (9), RS: MHeNs - R3 - Neuroscience, Klinische Neurowetenschappen, Promovendi MHN, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Med Staf Spec Neurochirurgie (9), MUMC+: MA Niet Med Staf Neurologie (9) |
| المصدر: | Hippocampus, 29, 102-110 Hippocampus, 29(2), 102-110. Wiley Hippocampus, 29(2), 102-110. WILEY-LISS Hippocampus, 29, 2, pp. 102-110 |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Drug Resistant Epilepsy, Wechsler Memory Scale, Protein Isoforms/biosynthesis, Duchenne muscular dystrophy, Gene Expression, Neuropsychological Tests, Hippocampus, WESTERN-BLOT, memory, Dystrophin, Cognition, 0302 clinical medicine, Protein Isoforms, Medicine, Dystrophin/biosynthesis, Episodic memory, Cognition/physiology, medicine.diagnostic_test, biology, 05 social sciences, WECHSLER MEMORY SCALE, Neuropsychological test, intelligence, temporal lobe epilepsy, Drug Resistant Epilepsy/genetics, hippocampal sclerosis, Female, GLYCOPROTEIN COMPLEX, Adult, BRAIN DYSTROPHIN, Cognitive Neuroscience, Hippocampus/metabolism, 050105 experimental psychology, Duchenne muscular dystrophy, hippocampal sclerosis, intelligence, memory, temporal lobe epilepsy, Temporal lobe, DUCHENNE MUSCULAR-DYSTROPHY, 03 medical and health sciences, Visual memory, Humans, 0501 psychology and cognitive sciences, Memory Disorders, Hippocampal sclerosis, Neuro- en revalidatiepsychologie, business.industry, Neuropsychology and rehabilitation psychology, QUANTIFICATION, medicine.disease, DELETIONS, INTELLECTUAL IMPAIRMENT, biology.protein, Memory Disorders/genetics, Cognition Disorders, business, Cognition Disorders/genetics, Neuroscience, 030217 neurology & neurosurgery, SYSTEM, TASK-FORCE |
| الوصف: | Item does not contain fulltext Dystrophin is an important protein within the central nervous system. The absence of dystrophin, characterizing Duchenne Muscular Dystrophy (DMD), is associated with brain related comorbidities such as neurodevelopmental (e.g. cognitive and behavioural) deficits and epilepsy. Especially mutations in the downstream part of the DMD gene affecting the dystrophin isoforms Dp140 and Dp71 are found to be associated with cognitive deficits. However, the function of Dp140 is currently not well understood and its expression pattern has previously been implicated to be developmentally regulated. Therefore, we evaluated Dp140 and Dp71 expression in human hippocampi in relation to cognitive functioning in patients with drug-resistant temporal lobe epilepsy (TLE) and post-mortem controls. Hippocampal samples obtained as part of epilepsy surgery were quantitatively analyzed by Western blot and correlations with neuropsychological test results (i.e. memory and intelligence) were examined. First, we demonstrated that the expression of Dp140 does not appear to differ across different ages throughout adulthood. Second, we identified an inverse correlation between memory loss (i.e. verbal and visual memory), but not intelligence (i.e. neither verbal nor performance), and hippocampal Dp140 expression. Finally, patients with TLE appeared to have similar Dp140 expression levels compared to post-mortem controls without neurological disease. Dp140 may thus have a function in normal cognitive (i.e. episodic memory) processes. 9 p. |
| وصف الملف: | application/pdf |
| تدمد: | 1050-9631 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec47037727b1c9727227cb968ce15d9aTest http://hdl.handle.net/2066/200761Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ec47037727b1c9727227cb968ce15d9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10509631 |
|---|