التفاصيل البيبلوغرافية
| العنوان: |
Multicenter prospective observational study of dupilumab‐induced ocular events in atopic dermatitis patients. |
| المؤلفون: |
Costedoat, Ingrid, Wallaert, Martin, Gaultier, Aurelie, Vasseur, Robin, Vanhaecke, Clelia, Viguier, Manuelle, Cordelette, Charles, Denoyer, Alexandre, Ferrier le Bouëdec, Marie‐Christine, Coutu, Adrien, Lamiaux, Marie, Tran, Thi Ha Châu, Lacour, Jean Philippe, Elmaleh, Valerie, Tetart, Florence, Gueudry, Julie, Tauber, Marie, Giordano‐Labadie, Francoise, Cassagne, Myriam, Nosbaum, Audrey |
| المصدر: |
Journal of the European Academy of Dermatology & Venereology; May2023, Vol. 37 Issue 5, p1056-1063, 8p |
| مصطلحات موضوعية: |
ATOPIC dermatitis, DRY eye syndromes, LONGITUDINAL method, SCIENTIFIC observation, DUPILUMAB, HEAD & neck cancer |
| مستخلص: |
Background: Although ocular adverse events are frequent in AD patients treated with dupilumab, their characterization remains limited due to a lack of prospective studies with a systematic ophthalmological examination. Objective: To examine the incidence, characteristics and risk factors of dupilumab‐induced ocular adverse events. Methods: A prospective, multicenter, and real‐life study in adult AD patients treated with dupilumab. Results: At baseline, 27 out of 181 patients (14.9%) had conjunctivitis. At week 16 (W16), 25 out of 27 had improved their conjunctivitis and 2 remained stable and 34 out of 181 patients (18.7%) had dupilumab‐induced blepharoconjunctivitis: either de novo (n = 32) or worsening of underlying blepharoconjunctivitis (n = 2). Most events (27/34; 79.4%) were moderate. A multivariate analysis showed that head and neck AD (OR = 7.254; 95%CI [1.938–30.07]; p = 0.004), erythroderma (OR = 5.635; 95%CI [1.635–21.50]; p = 0.007) and the presence of dry eye syndrome at baseline (OR = 3.51; 95%CI [3.158–13.90]; p = 0.031) were independent factors associated with dupilumab‐induced blepharoconjunctivitis. Limitations: Our follow‐up period was 16 weeks and some late‐onset time effects may still occur. Conclusion: This study showed that most dupilumab‐induced blepharoconjunctivitis cases are de novo. AD severity and conjunctivitis at baseline were not found to be associated risk factors in this study. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
