المؤلفون: Sabatine, Marc S., Giugliano, Robert P., Keech, Anthony C., Honarpour, Narimon, Wiviott, Stephen D., Murphy, Sabina A., Kuder, Julia F., Wang, Huei, Liu, Thomas, Wasserman, Scott M., Sever, Peter S., Pedersen, Terje R. Fish MP, Abrahamsen TE, Im K, Kanevsky E, Bonaca MP, Lira Pineda A, Hanlon K, Knusel B, Somaratne R, Kurtz C, Scott R, Accini Mendoza JL, Amerena J, Badariene J, Burgess L, Ceska R, Charng MJ, Choi D, Cobos JL, Dan GA, De Ferrari GM, Deedwania PC, Chopra VK, Erglis A, Ezhov MV, Ferreira J, Filipová S, Gaciong ZA, Pasierski T, Georgiev BG, Gonzalez-Galvez G, Gouni-Berthold I, Schäufele T, Hirayama A, Huber K, Rammer M, Kjaerulf Jensen H, Wermuth S, Jiang L, Jukema JW, Kraydashenko O, Leiter LA, Lewis BS, López-Miranda J, Lorenzatti AJ, Mach F, McAdam B, Nilsson L, Olsson Å, Rallidis L, Rogelio GG, Kerr Saraiva JF, Scheen A, Schiele F, Scott RS, Connolly D, Siu CW, Tay L, Thorgeirsson G, Tikkanen MJ, Tokgozoglu SL, Toth K, Viigimaa M, Wan Ahmad WA, Hennekens CH, Andreotti F, Baigent C, Brown WV, Davis BR, Newcomer JW, Wood SK, LaRosa J, Ansell B, Olsson A, Lowe C, Zahn L, Awtry E, Berger C, Croce K, Desai A, Gelfand E, Ho C, Leeman D, Link M, Norden A, Pande A, Rost N, Ruberg F, Silverman S, Singhal A, Vita J, Mackinnon I, Vogel DR, Leon de la Fuente R, Perna E, Amuchastegui M, Pacora F, Hershson A, Blumberg E, Glenny JA, Colombo H, Cuadrado JA, Nicolosi L, Rojas CG, Ulla MR, Hasbani EG, Cuneo C, Lopez Santi RG, Sanabria HD, Hrabar A, Lozada A, Begg A, Lehman S, Wittert G, Juergens C, Kostner K, Beltrame J, Simpson R, Sinhal A, Adams M, Kritharides L, Roberts Thomson P, Cross D, Thompson P, Van Gaal W, Cox N, Farshid A, Hammett C, Garrahy P, Prasan A, Horrigan M, Ebenbichler C, Hanusch U, Prager R, Schernthaner G, Luger A, Siostrzonek P, Toplak H, Bergler-Klein J, Paulweber B, Sinzinger H, Buysschaert I, Thoeng J, Vandekerckhove H, Catez E, Verheye S, Descamps O, Hoffer E, Wollaert B, Chenu P, van de Borne P, De Meulemeester M, Friart A, Charlier F, De Raedt H, Rietzschel E, Roelandt R, Lalmand J, Tavares Russo LA, Reis G, Duarte Barbosa EC, Vidotti MH, Fernandes Manenti ER, Dutra O, Leaes PE, Rech RL, Bertolim Precoma D, Nicolau JC, Amoedo R, Eliaschewitz FG, Pereira A, Kurtz Lisboa HR, Soares Piegas L, Cunha Borges JL, Ferreira Rossi PR, Pimentel Filho P, Bodanese LC, de Sa Cunha R, Moura Jorge JC, Ardito WR, Barroso de Souza WK, Hissa M, Izar MC, Manolova A, Kitova L, Kinova E, Tzekova M, Velchev V, Tarnovska-Kadreva R, Gotchev D, Petrov I, Raev D, Trendafilova-Lazarova D, Yotov Y, Lazov P, Rahimi S, St Amour E, Constance C, Pesant Y, Hess A, Anderson T, Sussex B, Henein S, Tsoukas G, Pandey AS, Bergeron J, Hart R, Gosselin G, Chehayeb R, Hamet P, Hartleib M, Mukherjee A, Halperin F, Petrella R, Bhargava R, Lonn E, Sabbah E, Bata I, Cha J, Gaudet D, Chapman K, Murthy D, Nigro F, Rupka D, Gossard D, Gupta M, Dowell A, Mansour S, Baass A, Geadah C, Huynh T, Peterson S, Poirier P, Sabe-Affaki G, Vertes G, Crowley D, Duchesne L, Pincetti Jofre CP, Potthoff Cardenas S, Conejeros Kindel C, Saavedra Gajardo VA, Lanas Zanetti F, Sepulveda Varela PA, Stockins Fernandez BA, Li W, Li D, Zhao S, Li Z, Wang J, Yang Y, Zhang L, Yang P, Zhang X, Huang H, Xue L, Zheng Z, Huang W, Dai H, Su H, Zeng X, Zheng Y, Tang Y, Yao Z, Sun Y, Du Y, Ge Z, Yan J, Chen X, Liu F, Pei H, Yang X, Cui H, Gu Y, Yang Z, Li J, Lian Y, Cui Y, Wang D, Jiang J, Li X, Chen J, Mo Z, Xu P, He Y, Zhou C, Qu P, Zhu Y, Liu Y, Shen X, Gao X, Terront Lozano MA, Moncada Corredor MA, Hernandez Triana E, Botero Lopez R, Coronel Arroyo JA, Quintero Baiz AE, Sanchez Vallejo G, Arana Londoño C, Molina de Salazar DI, Castellanos Bueno R, Manzur Jattin F, Cure Cure CA, Sotomayor Herazo A, Spinar J, Hala T, Machkova M, Klimsa Z, Polasek R, Jerabek O, Kazdera P, Pozdisek Z, Vaclavik J, Frana P, Elbl L, Kucera D, Kryza R, Malecha J, Reichert P, Sochor K, Ludka O, Kellnerova I, Peterka K, Zidkova E, Cech V, Brabec T, Fiserova N, Kvasnicka J, Rosolova H, Nemecek E, Adamkova V, Dunaj M, Pojsl S, Cepelak M, Podpera I, Kuchar L, Rysava D, Burianova H, Spinarova L, Skrobakova J, Charvat J, Homza M, Zemanek J, Koleckar P, Karen I, Krupicka J, Blaha V, Matuska J, Brotanek J, Cifkova R, Kuchar R, Vomacka Z, Kosek Z, Hulinsky V, Krejcova H, Kuchar J, Jelinek Z, Jelinek P, Markdanner Lindgren L, Saetre Lihn A, Korsgaard Thomsen K, Bronnum-Schou J, Nielsen H, Nielsen T, Egstrup K, Klausen IC, Mickley H, Hove J, Jeppesen J, Melchior T, Schmidt EB, Valter I, Rosenthal A, Kaik J, Kork A, Alt I, Strand J, Nieminen S, Kahri J, Suomi J, Nyman K, Strandberg TE, Piippo T, Savolainen M, Vikman S, Pucheu Y, Cariou B, Henry P, Ferrari E, Montalescot G, Ferrieres J, Roubille F, Bonnet B, Angoulvant D, Range G, Bammert A, Delarche N, Mariat C, Cayla G, Durlach V, Coisne D, Paillard F, Rouzier R, Goralski M, Khanoyan P, Cottin Y, Ziegler O, Khalife K, Le Corvoisier P, Motreff P, Spaulding C, VanBelle E, Bourhaial H, Opitz C, Kahrmann G, Contzen C, Appel K, Schenkenberger I, Rinke A, Trenk D, Maus O, Karakas M, Hanefeld M, Darius H, Hetzel G, Münzel T, Wöhrle J, Stawowy P, Marten I, Isermann B, Kast P, Vorpahl M, Bosiljanoff P, Hengstenberg C, Kassner U, Salbach P, Fischer M, Steiner S, Wagner S, Kraatz U, von Hodenberg E, Weyland K, Mantas I, Tziakas D, Bousboulas S, Patsilinakos S, Mertzanos G, Panagoulis C, Bilianou H, Skoumas I, Elisaf M, Manolis A, Moschos N, Kochiadakis G, Ntaios G, Richter D, Athyros V, Kolovou G, Danias P, Melidonis A, Fan KYY, Siu SC, Hornyik A, Lakatos F, Zilahi Z, Nagy K, Laszlo Z, Peterfai E, Lupkovics G, Andreka P, Merkely B, Herczeg B, Piros GA, Salamon C, Mark L, Papp A, Szakal I, Edes I, Mohacsi A, Tomcsanyi J, Hajko E, Nagy A, Papp E, Kiss R, Karadi I, Sigurdsson A, Jain A, Pai R, Kothiwale V, Kulkarni G, Mahajan A, Aggarwal S, Mehta V, Rajadhyaksha G, Joshi A, Khandait V, Parmar M, Tyagi S, Airody Govinda R, Dwivedi SK, Parikh K, Pothineni RB, Solanki B, O’Donnell M, Crean P, Barton J, Shechter M, Shotan A, Klutstein M, Chorin E, Gavish D, Kracoff O, Atar S, Rigler S, Hasin Y, Schiff E, Merlini P, Rapezzi C, Pirro M, Gonnelli S, Floresta AM, Mennuni M, Ardissino D, Senni M, Marenzi G, Marcucci R, Sampietro T, Cosmi F, Perrone Filardi P, De Caterina R, Fedele Francesco, Moretti L, Biasucci LM, Ferri C, Go Y, Kiyosue A, Higashi Y, Tokunaga T, Kawasaki T, Sakagami S, Namba S, Saku K, Oku K, Arakawa T, Iida H, Nakamura Y, Yamamoto K, Hata Y, Katsuda Y, Koga Y, Shimizu M, Uehara H, Kajiyama S, Okamoto H, Shinozaki T, Fujino Y, Funazaki T, Higa N, Kaigawa K, Koike A, Nakane H, Sato K, Satoh Y, Shirasawa K, Sugino H, Tanabe J, Uemura O, Yoshimichi G, Akai A, Himeno H, Inage T, Inoko M, Kadokami T, Noguchi Y, Yamashita K, Yasumura Y, Yuge M, Hosokawa S, Kawamitsu K, Kozuma K, Matsuo H, Nakashima E, Okada M, Wada A, Yokoya K, Iwade K, Kawabata K, Tanno H, Ako J, Fujita H, Izumiya Y, Kanno M, Nunohiro T, Ohmura H, Ueno T, Kakurina N, Jasinkevica I, Stukena I, Veze I, Eglite R, Teterovska D, Sime I, Strazdiene V, Venceviciene L, Gustiene O, Radzeviciene-Jurgute R, Kucinskiene A, Maskon O, Lee CY, Erng T, Gan HW, Mohamed Yusof AK, Ramanathan GL, Liew H, Lopez Alvarado A, Nevarez Ruiz LA, De los Rios Ibarra MO, Bazzoni Ruiz AE, Ramos Lopez GA, Llamas Esperon GA, De la Peña Topete GDJ, Violante Ortiz RM, Illescas Diaz JJ, Leon Gonzalez S, Sanchez Diaz CJ, Mendez Machado GF, Venegas Carrillo LA, Aldrete Velasco JA, Cardona Muñoz EG, Leiva Pons JL, Perez Alva JC, van der Zwaan C, Oomen A, van de Wal R, Magro M, Boswijk D, Janus C, Groutars R, Tonino W, Cornel JH, Oude Ophuis A, Troquay R, Liem A, Westendorp I, Van Hessen M, Lok D, De Nooijer C, Den Hartog F, Van Beek E, Bendermacher P, Jansen R, Römer T, Rensing B, Hersbach F, Herrman J, Ladyjanskaia G, Karalis I, Linssen G, Bokern M, Visman A, Kooij A, Monajemi H, Lieverse A, Baker J, Tie S, Risberg K, Hysing J, Pedersen T, Hoivik HO, Norheim P, Solnor L, Hovland A, Kjaernli T, Jocson G, Coching RM, Batalla E, Go A, Habaluyas R, Barcinas R, Sy RA, Estepar RA, Germar A, Trebacz J, Szymkowiak K, Wnetrzak-Michalska R, Kopaczewski J, Przekwas-Jaruchowska M, Kania G, Zabowka M, Mirek-Bryniarska E, Dabrowska M, Napora P, Konieczny M, Spyra J, Lysek R, Pijanowski Z, Grzegorzewski B, Bednarkiewicz Z, Kinasz L, Antkowiak-Piatyszek K, Stania K, Szpajer M, Staneta P, Skonieczny G, Ksiezycka-Majczynska E, Blicharski T, Piepiorka M, Wozakowska-Kaplon B, Zechowicz T, Ilkowski J, Lubiszewska B, Hiczkiewicz J, Wierzbicka K, Kosior D, Garbocz P, Kubica J, Raczak G, Wozniak I, Cygler J, Kramarczuk E, Bystryk L, Pentela-Nowicka J, Dabrowski M, Podolec P, Zieba B, Mosiewicz J, Dubaniewicz W, Banach M, Tyszecka G, Lepich T, Rychlewska-Hanczewska A, Guzik T, Monteiro P, Pereira H, Oliveira L, Matos P, Soares Goncalves S, Leitao A, Vasco Salgado A, Timoteo AT, Pintilei E, Badila E, Militaru C, Tudoran M, Arsenescu-Georgescu C, Mitu F, Zdrenghea D, Lighezan D, Teodorescu I, Popescu MI, Coman I, Vintila MM, Vishnevsky A, Lukyanov Y, Blokhin A, Kostenko V, Shvarts Y, Markov V, Motylev I, Dronov D, Sherenkov A, Barbarash O, Shutemova E, Bolshakova O, Kobalava Z, Voevoda M, Treshkur T, Zrazhevskiy K, Pimenov L, Solovev O, Tarasov N, Arkhipov M, Freidlin M, Shalaev S, Yakhontova P, Shustov S, Goloshchekin B, Panov A, Bart B, Bubnova M, Gordeev I, Osipova I, Tereshenko S, Solovieva E, Meshkov A, Zateyshchikov D, Tan JL, Subramaniam T, Pella D, Fulop P, Antalik L, Dzupina A, Banikova A, Sosovec D, Urgeova L, Mazur J, Hranai M, Banik M, Vinanska D, Lennerova J, Kovar F, Pastrnakova E, Uhliar R, Blasko P, Gonsorcik J, Lukacova J, Oriesek R, Hatalova K, du Toit M, Ebrahim I, Vawda G, Lipschitz S, Blignaut S, Engelbrecht J, Coetzer TF, Pretorius M, Urbach D, Badat A, Pillay S, Van Zyl L, Abelson M, van der Walt E, Moodley R, Jacovides A, Oosthuysen WM, Klug E, Lottering H, Kok J, Saaiman J, Dawood S, De Jong DM, Kapp C, Makotoko E, Bayat J, Sarvan M, Vally T, Stapelberg A, Kim M, Bae J, Cho Y, Kim S, Han KH, Her S, Kim B, Lee S, Hong B, Kim W, Rha S, Jeong M, Shin GJ, Vida Gutierrez M, Valdes Chavarri M, Pinto Sala X, Gonzalez Juanatey JR, Civeira Murillo F, Zamorano Gomez JL, Lekuona Goya I, Iñiguez Romo A, Cordero Fort A, Ascaso Gimilio JF, Millan Nuñez-Cortes J, Lindholm C, Söderberg S, Suutari A, Berglund S, Mooe T, Kusiak D, Bandh S, Dahlén G, Olsson S, Witt N, Tydén P, Johansson P, Cizinsky S, Falck G, Pettersson SI, Rasmanis G, Östergren J, Moccetti T, Beer HJ, Eberli F, Krähenbühl S, Linka A, Ackermann D, Michel P, Yeh H, Tsai CF, Wu C, Hsia C, Juang J, Hsieh I, Lai W, Huang C, Hsieh Y, Sahin T, Duzenli M, Yigit Z, Demir M, Yilmaz MB, Muderrisoglu IH, Kirma C, Ercan E, Kayikcioglu L, Balbay Y, Lymar I, Kulynych O, Prokhorov O, Karpenko O, Kraіz I, Vakaliuk I, Stanislavchuk M, Korzh O, Rudyk I, Zhurba S, Svishchenko Y, Tseluyko V, Gyrina O, Reshotko D, Kopytsya M, Volkov V, Myshanych G, Rebrov B, Rishko M, Rudenko L, Shatylo V, Parkhomenko O, Yena L, Golovchenko O, Sorokina I, Malynovsky Y, Ivan P, Blagden M, Dear H, Mathew A, Lagocki S, Kondagunta V, Ahsan A, McKinnon C, Douglas F, Thom S, Fiore G, Caulfield M, Lynch M, Thomas H, Bain S, Hall A, McNally D, Fisher M, Keeling P, Al-Bahrani A, Lip G, Ellery A, Purohit J, Travill C, Cappuccio F, Davis G, Gaunt R, Adlam D, Asamoah N, Jaafar F, McCormack T, Jupp B, Pye M, Ainsworth P, Chauhan A, Paul N, Fairlie H, Fox C, Muzulu S, Trevelyan J, Aggarwal R, Issa B, Saravanan P, Cruickshank K, Gorog D, Heller S, Newby D, Nicolson A, Hare PO, Donnelly P, Rutherfurd S, de Belder M, Finlayson J, Harvey J, Hoye A, Kingston D, Sarkar D, Negahban A, Webster J, Wyatt N, Muir S, Cummings M, Mackenzie I, Senior R, Capps N, Fotherby K, McIntyre H, Aldegather J, Dixon L, Saksena R, Butler R, Ramstad D, Pierpont B, Levinson D, Mohammed A, Haddad T, Goel A, Dave K, Haught WH, Desire A, Hershon K, Napoli M, Tami L, Rothschild R, Khurana S, Gupta D, Cheung D, Hearne S, Grubb S, Miller A, Baird I, Marcus A, Srivastava S, Forgosh L, Fritz R, Mays M, Bertolet B, Reddy J, Khan M, Nakhle S, Dill S, Fishbein G, Khan B, Marais H, Reschak M, Malone M, Nadar V, Whitney R, Reichman A, Reyes H, El Shahawy M, Rabinowitz A, Weinstein D, Farhat N, Onyema D, Potu R, Runquist L, Barnum O, Crater T, Fialkow J, Shah A, Thompson C, Wiseman A, Doyle T, Henderson D, Herzog W, Schnitzler R, Carr K, Davis M, Nagajothi N, Olsen S, Rogers W, Rubino J, Singh I, Tarleton G, Bhagwat R, Clardy D, Jardula M, Robinson J, Torres M, Vijay N, Farris N, Lillo J, Moriarty P, Recknor C, Berlacher P, Christensen T, Gabra N, Issa M, Janik M, Lawless A, Molter D, Stout E, Brezina B, Claxton E, Linsky R, Poock J, Remler R, Roseman H, Schramm E, Al-Joundi T, Amin J, Hitchcock J, Isserman S, Kirstein J, Rider J, Shalek M, Sherman H, Bernstein M, Chandra L, Hatharasinghe R, Ibrahim H, Iteld B, Linzmeyer K, Seaton B, Zeig S, Christofides E, Dunbar R, Griffin S, Kohli N, Koren M, Pharr W, Purdy D, Spencer R, Yeoman G, Banerjee S, Cheek HB, Engel E, Hamroff G, Huling R, Kozlowski L, Levin P, Makam S, Meengs M, Bhushan R, Erickson B, Herman L, Lo E, McDowell E, McGrew F, Miller M, Ord J, Webel R, Wilhoit G, Wise J, Yang E, Budoff M, Collins J, Dauber I, Dobkin L, Focil A, Gandy W, Pasquini J, Ramos M, Rodriguez D, Rosenson R, Sanford K, Schlau A, Snyder B, Stonesifer L, Tang A, De Souza J, Elam M III, French J, Guyton J, Hage Korban E, Kereiakes D, King M, Loh I, Navarro J, Simons R, Tobin T, Younis L, Aboufakher R, Baldari D, Ballantyne C, Broughton R, Eaton C, Johnston J, Simon W, Thomson S, Vora K, Youngman D, Alzohaili O, Auerbach E, Brown C, Burrough B, Chen Y, Gilpatrick M, Landzberg J, Mitchell C, Rice L, Rubenfire M, Sofley CW, Strobl D, Atassi K, Davila W, Diogo J, Fagan T, Joffe I, Krishna J, Osea E, Penny W, Rowe W, Shapiro M, Welker J, Benton R, Dobratz D, Fortuin F, Graham J, Henry B, Kusnick B, Lutskiy M, McRae A, Saway W, Scott J, Shah M, Weinberg B, Zarich S, Acheatel R, Case C, Earl J, Fernandez S, Giugliano G, Handelsman Y, Hermany P, Holder S, Kashyap M, Khan A, Lader E, Peniston J, Raoof T, Sacco J, Shore K, Spriggs D, Stringam S, Tahirkheli N, Delgado E, Derian W, Greenwald J, Harris M, Jackson R, Marhefka G, McElveen W, Mooss A, Morris 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المساهمون: Sabatine, Marc S., Giugliano, Robert P., Keech, Anthony C., Honarpour, Narimon, Wiviott, Stephen D., Murphy, Sabina A., Kuder, Julia F., Wang, Huei, Liu, Thoma, Wasserman, Scott M., Sever, Peter S., Pedersen, Terje R., Fish MP, Abrahamsen, Te, Im, K, Kanevsky, E, Bonaca, Mp, Lira Pineda, A, Hanlon, K, Knusel, B, Somaratne, R, Kurtz, C, Scott, R, Accini Mendoza, Jl, Amerena, J, Badariene, J, Burgess, L, Ceska, R, Charng, Mj, Choi, D, Cobos, Jl, Dan, Ga, De Ferrari, Gm, Deedwania, Pc, Chopra, Vk, Erglis, A, Ezhov, Mv, Ferreira, J, Filipová, S, Gaciong, Za, Pasierski, T, Georgiev, Bg, Gonzalez-Galvez, G, Gouni-Berthold, I, Schäufele, T, Hirayama, A, Huber, K, Rammer, M, Kjaerulf Jensen, H, Wermuth, S, Jiang, L, Jukema, Jw, Kraydashenko, O, Leiter, La, Lewis, B, López-Miranda, J, Lorenzatti, Aj, Mach, F, McAdam, B, Nilsson, L, Olsson, Å, Rallidis, L, Rogelio, Gg, Kerr Saraiva, Jf, Scheen, A, Schiele, F, Connolly, D, Siu, Cw, Tay, L, Thorgeirsson, G, Tikkanen, Mj, Tokgozoglu, Sl, Toth, K, Viigimaa, M, Wan Ahmad, Wa, Hennekens, Ch, Andreotti, F, Baigent, C, Brown, Wv, Davis, Br, Newcomer, Jw, Wood, Sk, LaRosa, J, Ansell, B, Olsson, A, Lowe, C, Zahn, L, Awtry, E, Berger, C, Croce, K, Desai, A, Gelfand, E, Ho, C, Leeman, D, Link, M, Norden, A, Pande, A, Rost, N, Ruberg, F

مصطلحات موضوعية: Aged, antibodies, monoclonal, anticholesteremic agent, atherosclerosi, cardiovascular disease, cholesterol, ldl, double-blind method, drug therapy, combination, female, follow-up studie, human, hydroxymethylglutaryl-coa reductase inhibitor, hypercholesterolemia, incidence, least-squares analysi, male, middle aged, proprotein convertase 9, medicine (all)

الوصف: BACKGROUND Evolocumab is a monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and lowers low-density lipoprotein (LDL) cholesterol levels by approximately 60%. Whether it prevents cardiovascular events is uncertain. METHODS We conducted a randomized, double-blind, placebo-controlled trial involving 27,564 patients with atherosclerotic cardiovascular disease and LDL cholesterol levels of 70 mg per deciliter (1.8 mmol per liter) or higher who were receiving statin therapy. Patients were randomly assigned to receive evolocumab (either 140 mg every 2 weeks or 420 mg monthly) or matching placebo as subcutaneous injections. The primary efficacy end point was the composite of cardiovascular death, myocardial infarction, stroke, hospitalization for unstable angina, or coronary revascularization. The key secondary efficacy end point was the composite of cardiovascular death, myocardial infarction, or stroke. The median duration of follow-up was 2.2 years. RESULTS At 48 weeks, the least-squares mean percentage reduction in LDL cholesterol levels with evolocumab, as compared with placebo, was 59%, from a median baseline value of 92 mg per deciliter (2.4 mmol per liter) to 30 mg per deciliter (0.78 mmol per liter) (P<0.001). Relative to placebo, evolocumab treatment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patients [11.3%]; hazard ratio, 0.85; 95% confidence interval [CI], 0.79 to 0.92; P<0.001) and the key secondary end point (816 [5.9%] vs. 1013 [7.4%]; hazard ratio, 0.80; 95% CI, 0.73 to 0.88; P<0.001). The results were consistent across key subgroups, including the subgroup of patients in the lowest quartile for baseline LDL cholesterol levels (median, 74 mg per deciliter [1.9 mmol per liter]). There was no significant difference between the study groups with regard to adverse events (including new-onset diabetes and neurocognitive events), with the exception of injection-site reactions, which were more common with evolocumab ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28304224; info:eu-repo/semantics/altIdentifier/wos/WOS:000400442300005; volume:376; issue:18; firstpage:1713; lastpage:1722; numberofpages:10; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11573/1150634Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85017341929

الإتاحة: https://doi.org/10.1056/NEJMoa1615664Test
http://hdl.handle.net/11573/1150634Test

المؤلفون: Eikelboom J. W., Connolly S. J., Bosch J., Dagenais G. R., Hart R. G., Shestakovska O., Diaz R., Alings M., Lonn E. M., Anand S. S., Widimsky P., Hori M., Avezum A., Piegas L. S., Branch K. R. H., Probstfield J., Bhatt D. L., Zhu J., Liang Y., Maggioni A. P., Lopez-Jaramillo P., O'Donnell M., Kakkar A. K., Fox K. A. A., Parkhomenko A. N., Ertl G., Stork S., Keltai M., Ryden L., Pogosova N., Dans A. L., Lanas F., Commerford P. J., Torp-Pedersen C., Guzik T. J., Verhamme P. B., Vinereanu D., Kim J. -H., Tonkin A. M., Lewis B. S., Felix C., Yusoff K., Steg P. G., Metsarinne K. P., Bruns N. C., Misselwitz F., Chen E., Leong D., Yusuf S., Aboyans V., Ha J., Keltai K., Lamy A., Liu L., Moayyedi P., Sharma M., Stoerk S., Varigos J., Bhagirath V., Bogaty P., Botto F., Catanese L., Donato Magno J., Fabbri G., Gabizon I., Gosselin G., Halon D., Heldmann M., Lamelas P., Lauw M., Leong Y., Liang D., Lutay Y., Maly M., Mikulik R., Nayar S., Ng K., Perera K., Pirvu O., Ronner E., Sato S., Smyth A., Sokolova E., Wiendl M., Winkelmann B., Yang X., Yufereva Y., Cairns J., Sleight P., DeMets D., Momomura S. I., Prins M., Ramsay T., Goto S., Rouleau J. L., Schumi J., Thabane L., Casanova A., Bangdiwala S., Deng E., Dyal L., Khatun R., Marsden T., Pogue J., Tang C., Wong G., Yuan F., Aman S., Ariz A., Ashton H., Belanger J., Belanger M., Brettell K., Chandra J., Choppick C., Cisternino D., Cuncins-Hearn A., Di Marino M., Diao L., Dwomoh S., Dykstra A., Galatsis E., Gasic T., Gutierrez J., Hamilton L., Irwin L., Lapensee C., Li A., Lu X., MacRae L., Malik S., Malvestiti A., Mastrangelo J., Maystrenko A., O'Donnell L., Reeh K., Szymkow P., Thomas S., Thrasher D., Tyrwhitt J., White L., Bastone R., Berkowitz S., Dias A., Ho K., Keller L., Lanius V., Lister K., Merten C., Muehlhofer E., Schmidt K., Tasto C., Tsihlias E., Woroniecka-Osio A., Orlandini A., Niemann G., Pascual A., Toscanelli S., Cabezon M., Debaveye B., Meeusen K., Luys C., Broos K., Vandenberghe K., Luyten A., Oliveira GBF., Vila Nova D. C., Konishi MYN., Lonn A., Turbide G., Cayer M., Rovito C., Standen D., Li J., Lopez Pico M., Dusek R., Buzalka V., Larsen J., Paucar M. J., Saarinen M., Simon T., Bezault M., Le Lay M., Epstein L., Fajardo-Moser M., Roser C., Putz-Todd G., Scheidemantel F., Poehler D., Renner J., Hargitai A., Doherty A. O., Duffy N., Roarty C., Nolan A., Power A., Yuval R., Ben Ari M., Greenblatt S., Marmor Y., Lucci D., Ceseri M., Baldini E., Cipressa L., Miccoli M., Goto M., Yamasowa H., Kajiwara M., Takase D., Ikeguchi K., Matsumoto M., Ishii M., Asai J., Nozaki D., Akatsuka T., Yoshida T., Shahadan S., Md Nasir N., Schut A., Vinck L., van Leeuwen M., Sanchez J., Aquino M. R., Mararac T., Benedyk K., Iordache A., Ciobanu A., Rimbas R., Dragoi Galrinho R., Magda S., Mihaila S., Mincu R., Suran B., Cotoban A., Matei L., Kursakov A., Rusnak P., Zakharova A., Demidova E., Commerford A., Lee S., Ju I., Gunolf M., Lorimer A., Parkhomenko L., Johnson J., Anderson J., Norby-Slycord C., Sala J., Sicer M., Rasmussen M., Luciani C., Cartasegna L., Beltrano C., Medek G., Vico M., Lanchiotti P., Martella C., Hominal M., Castoldi M., Casali W., Raimondi S., Hasbani E., Prado A., Paterlini G., Waisman F., Leonard M., Caccavo A., Alarcon V., Zaidman C., Guerlloy F., Vogel D., Imposti H., Dominguez A., Hrabar A., Fernandez A., Schygiel P., Sokn F., Cuneo C., Gutierrez Carrillo N., Martinez G., Luquez H., Costantino M., Ruiz M., Beccetti N., Mackinnon I., Cluigt N., Ahuad Guerrero R., Fanuele M., Campisi V., Costabel J., Romanelli M., Bartolacci I., Echeverria M., Pedrotti M., Montana O., Camino A., Crespo C., Barbieri M., Lopez Santi R., Tonin H., Heffes R., Gomez Vilamajo O., Vanesio F., Allegrini E., Garcia Duran R., Garcia C., Garcia Duran L., Schiavi L., Mana M., Bordonava A., Rodriguez M., Gutierrez M., Garrido M., Rodriguez C., Ingaramo A., Costamagna O., Almagro S., Gerbaudo C., Pelagagge M., Bustamante Labarta M., Novaretto L., Maldini A., Lopez L., Albisu Di Gennero J., Ibanez Saggia L., Garcia Vilkas A., Alvarez M., Stoermann W., Vita N., Vottero E., Macin S., Cocco M., Onocko M., Dran R., Gimenez C., Cardona M., Guzman L., Guzman P., Martinez D., Sarjanovich R., Huerta C., Scaro G., Cuadrado J., Rodriguez G., Nani S., Guardiani F., Litvak Bruno M., Ceconi G., Chacon C., Casado M., Fernandez Moutin M., Maffei L., Sassone S., Yantorno M., Grinfeld D., Vensentini N., Rolandi F., Fallabrino L., Majul C., Paez O., Visser M., Luciardi H., Mansilla V., Gonzalez Colaso P., Ferre Pacora F., Jure H., Parody M., Espeche E., Whelan A., Boyle A., Collins N., Roberts-Thomson P., Rogers J., Caroll P., Colquhoun D., Williams L., Shaw J., Blombery P., Amerena J., Lee C., Hii C., Royse A., Royse C., Singh B., Selvanayagam J., Jansen S. J., Thompson P., Lo W., Hammett C., Poulter R., Graves S., Narasimhan S., Van Den Heuvel P., Wollaert B., Sinnaeve P., Fourneau I., Meuris B., Vanassche T., Ector B., Janssens L., Debonnaire P., Vandekerckhove Y., Van de Borne P., Wautrecht J., Motte S., Leroy J., Schroe H., Vrolix M., Ferdinande B., Vranckx P., Benit E., Elegeert I., Lerut P., Wallaert P., Hoffer E., Borgoens P., Dujardin K., Brasil CKOI., Del Monaco M. I., Uint L., Pavanello R., Precoma D. B., Vianna H. S., Abrantes J., Morelli J., Manenti E., Jaeger C., Reis G., Giorgeto F. E., Franca C. C. B., Quadros TFS., Saraiva J., Costa M., de Camargo O., Marson Lopes M., Silva J., Maia L. N., Nakazone M. A., Mouco OMCC., Lemos MABT., Hernandes M. E., Pantano G. S., de Castro JCM., Rossi PRF., Guedes AAM., dos Santos L. B., dos Santos F. R., Vidotti M. H., Zimmermann S. L., Rech R., Nunes C., Abib E., Oliveira KLC., Leaes P. E., Botelho R. V., Navarro ALC., Silva R. A., Arantes FBB., Dutra O., Vaz R., Souza WKSB., Souza ASB., Queiroz WCB., Braile M., Ferreira V., Izukawa N. M., Prakasan A. K., Nicolau J. C., Dalcoquio T. F., Tanajura LFL., Serrano C. V., Hueb W. A., Minelli C., Borsetti Neto F. A., Nasi L. A., Martins SCO., Oliveira LFA., Silva MAV., Ferreira J. O., de Carvalho Cantarelli M. J., Tytus R., Pasyk E., Pandey A. S., Rowe A., Cha J., Vizel S., Babapulle M., Semelhago L., Saunders K., Haligowski D., Berlingieri J., Nisker W., Kiaii B., Romsa J., Chu M., Nagpal D., Guo R., Mckenzie N., Quantz M., Bhargava R., Bhargava M., Mehta P., Hill L., Heslop W., Fell D., Hess A., Zadra R., Zeman P., Srivamadevan M., Lam A., Tai S., Al-Qoofi F., Spence F., Anderson T., Kieser T., Kidd W., Fedak P., Smith E., Har B., Brown C., Forgie R., Hassan A., Pelletier M., Searles G., Marr D., Bessoudo R., Douglas G., Legare J., Petrella R., Pavlosky W., Ricci J., Galiwango P., Janmohamed A., Kassam S., Mukherjee A., Vijayaraghavan R., Burstein J., D'Mello N., Glanz A., Noiseux N., Stevens L. M., Basile F., Prieto I., Normandin L., Helou J., Do Q. B., Bainey K., Tymchak W., Welsh R., Merali F., Pandith V., Heffernan M., Orfi J., Mcconachie D., Jedrzkiewicz S., Della Siega A., Robinson S., Nadra I., Poirier P., Dagenais F., Voisine P., Mohammadi S., Doyle D., Baillot R., Charbonneau E., Dumont E., Kalavrouziotis D., Perron J., Jacques F., Laflamme M., Brulotte S., Crete M., Degrace M., Delage F., Grondin F., Lemieux A., Michaud N., Saulnier D., Ross M. K., Nguyen M., Harvey R., Daneault B., Hartleib M., Guzman R., Nguyen T., Singal R., Bourgeois R., Landry D., Kamel S., Rupka D., Kuritzky R., Khaykin Y., Phaneuf D. C., Desjardins V., Coll X., Huynh T., Pilon C., Mansour S., Lemire F., Kokis A., Potvin J., Campeau J., Audet M., Boulianne M., Dupuis R., Lauzon C., Pruneau G., Senay B., Pichette F., Cieza T., Breton R., Belisle P., Barabas M., Diaz A., Costa R., Absi F., Garand M., Rheault A., Lemay C., Gisbert A., Raymond A., Barrero M., Gagne C. E., Rheault P., Pepin-Dubois Y., Johnston J., Mundi A., Cohen G., Shukle P., Baskett R., Hirsch G., Ali I., Stewart K., Fenton J., Pudupakkam S., Willoughby R., Czarnecki W., Roy A., Montigny M., Descarries L., Mayrand H., Comtois H., Essiambre R., Ringuette G., Boutros G., Gendreau R., Pham L., Nguyen V., Nguyen-Thanh H. K., Ben-Yedder N., Nawaz S., Fremes S., Moussa F., Shukla D., Labonte R., Jano G., Bobadilla B., Saavedra J., Bahamondes J., Cobos J., Grunberg E., Corbalan R., Verdejo H., Medina M., Vega M., Nahuelpan L., Castania F., Raffo C., Vargas A., Reyes T., Vargas D., Perez L., Arriagada G., Potthoff S., Godoy J., Stockins B., Larenas G., Quininao F., Sepulveda P., Trucco V., Pincetti C., Saavedra S., Silva P., Vejar M., Rodriguez T., Rodriguez J., Tian H., Zhang J., Meng Y., Wu X., Wu Q., Wang Q., Mu Y., Yang J., Wang F., Zhang W., Ke Y., Jiang H., Yin P., Jia K., Chen C., Wang Z., Qi B., Yu L., Feng G., Li L., Jiang L., Wu S., Yu H., Wu Z., Ding R., Liu S., Xu H., Cao H., Bai X., Zheng Y., Liu Z., Sun H., Yang P., Li B., Feng Z., Yang Y., Xu Z., Wu W., Meng Q., Ge J., Dai Y., Yang H., Chen X., Tian X., Shi Y., Hu T., Zhang R., Zhao Q., Quan W., Zhu Y., Zheng Z., Zhang S., Zhao Y., Zhao C., Wang R., Tao L., Hu D., Wang Y., Fan F., Huang W., Xia X., Fu G., Jiang D., Wang M., Li C., Xu K., Dong Y., Chen Y., Wu D., Wang C., Sun X., Lu S., Zhou X., Kong Y., Zhang B., Sotomayor A., Suarez M., Ripoll D., Herrera O., Accini Mendoza J., Saad Cure C., Reyes M., Vidal T., Donado Beltran P., Hernandez Jaimes E., Castillo H., Rocha C., Forero L., Zarate Bernal D., Vanstrrahle Gonzalez L., Urina Triana M., Quintero A., Ramirez N., Balaguera Mendoza J., Aroca Martinez G., Cotes C., Mercado A., Lastra Percy X., Perez Mayorga M., Rodriguez N., Molina De Salazar D., Perez Agudelo J., Lopez Villegas L., Agudelo Ramos L., Melo Polo M., Esparza Albornoz A., Forero Gomez J., Sanchez Vallejo G., Aristizabal J., Gallego A., Contreras C., Yepez J., Angel Escobar J., Manzur J F., Cohen L., Boneu D., Garcia Lozada H., Barrios L., Celemin C., Diego M., Garcia Ortiz L., Montoya C., Ramirez E., Arcos Palma E., Ceron J., Acosta G., Gomez Mesa J., Velasquez J., Barreto D., Trujillo Dada F., Trujillo Accini F., Cano R., Corredor De La Cruz K., Maria V., Palmera J., Vesga B., Hernandez H., Moreno Silgado G., Aruachan Vesga S., Burgos Martinez E., Quintero Villareal G., Solano Ayazo F., Porto Valiente J., Zidkova E., Krupicka P., Bultas J., Mandysova E., Lubanda J., Horak J., Belohlavek J., Kovarnik T., Gorican K., Rucka D., Smid O., Dostalova G., Skalicka H., Karetova D., Pavlinak V., Kuchynkova S., Marek J., Rob D., Ravlykova K., Prochazka P., Siranec M., Urbanec T., Vareka T., Nesvadbova P., Kaletova M., Indrakova J., Kryza R., Heczko M., Hanak P., Jancar R., Kocurkova L., Marcinek G., Cermak O., Drasnar T., Richter M., Kaspar J., Spinar J., Parenica J., Parenicova I., Schildberger J., Toman O., Ludka O., Poloczek M., Musil V., Miklik R., Labrova R., Lokaj P., Felsoci M., Bocek O., Kanovsky J., Zatocil T., Jerabek P., Matuska J., Jankovic M., Jankovicova H., Tesak M., Sulc D., Svacinova H., Radvan M., Bednar J., Motovska Z., Petr R., Fischerova M., Branny M., Vodzinska A., Cerny J., Indrak J., Sknouril L., Maly J., Vacek T., Prazak O., Broulikova K., Hajsl M., Jarkovsky P., Kamenik L., Kotik I., Krcova E., Sedlon P., Skvaril J., Cernohous M., Kohoutek J., Levcik M., Holek M., Hajdusek P., Foltynova Caisova L., Novak V., Kladivkova M., Slaby J., Houra M., Vojtisek P., Novotny V., Lazarak T., Pliva M., Pirk J., Barciakova L., Jandova R., Adamkova V., Galovcova M., Peterkova L., Turek D., Prochazka J., Belohoubek J., Spinarova L., Panovsky R., Novotny P., Krejci J., Hude P., Ozabalova E., Godava J., Honek T., Kincl V., Benesova M., Buckova J., Canadyova J., Mokracek A., Homza M., Stverka P., Florian J., Lukac B., Polasek R., Kucera P., Seiner J., Karasek J., Coufal Z., Stastny J., Cernicek V., Skalnikova V., Jiresova E., Brat R., Sieja J., Gloger J., Berger P., Prochazkova I., Samlik J., Brtko M., Tuna M., Polansky P., Omran N., Myjavec A., Hrdinova M., Jansky P., Kratochvilova R., Burkert J., Koubek F., Fiala R., Paulasova Schwabova J., Lindner J., Hlubocky J., Spacek M., Marcian P., Hanak V., Pozdisek Z., Lonsky V., Santavy P., Troubil M., Straka Z., Budera P., Fojt R., Talavera D., Tretina M., Nemec P., Orban M., Bedanova H., Wiggers H., Tougaard R., Larsen A., Nielsen H., Mattsson N., Gunnar G., Bruun N., Folke F., Soendergaard K., Koeber L., Frydland M., Fuchs A., Bang L., Houlind K., Olsen M., Soerensen V., Overgaard Andersen U., Dixen U., Refsgaard J., Moeller D., Zeuthen E., Lund J., Soegaard P., Jensen S., Duarte Y., Duarte W., Caceres S., Pow Chon Long F., Penaherrera C., Anzules N., Sanchez M., Zuleta I., Lopez J., Villota M., Sanchez H., Perugachi C., Gomez S., Morejon P., Marmol R., Guaman S., Trujillo F., Escobar M., Carrera F., Ponce F., Teran P., Carrasco S., Tuomilehto J., Humaloja K., Lindberg L., Tuomilehto H., Tuominen M. L., Kantola I., Juliard J., Feldman L., Ducrocq G., Boulogne C., Petitalot V., Leclercq F., Roubille F., Agullo A., Ferrari E., Chiche O., Moceri P., Boccara F., Charbonnier M., Azeddine B., Ederhy S., Soulat Dufour L., Cohen A., Etienney A., Messas E., Calvalido A., Galloula A., Zarka S., Courtois M. C., Mismetti P., Accassat S., Buchmuller A., Moulin N., Bertoletti L., Seffert B., Sevestre M., Samy Modeliar Remond S., Dupas S., Mardyla J., Le Gloan S., Cayla G., Cornillet L., Schmutz L., Motreff P., Souteyrand G., Amonchot A., Barber-Charmoux N., Combaret N., Malcles G., Brenner S., Christa M., Duengen H., Krackhardt F., Bobenko A., Hashemi D., Stellbrink C., Stellbrink E., Koster C., Guerocak O., Bourhaial H., Oumbe Tiam S., Kemala E., Froemke J., Kadel C., Moellinger H., Friedrich K., Rafoud K., Braun-Dullaeus R., Herold J., Ganzer M., Jeserich M., Kimmel S., Haggenmiller S., Schoengart H., Voehringer H., Opitz C., Appel K., Appel S., Utech A., Finger C., Duersch M., Dorsel T., Wistorf N., Grude M., Nikol S., Ueberschaer D., Kast P., Darius H., Sommer S., Girke F., Oeztuerk C., Ranft J., Mikalo A., Schellong S., Voigts B., Mueller C., Jungmair W., Davierwala P., Misfeld M., Bomke K., Akhavuz O., Haensig M., Vorpahl M., Blem A., Langer G., Nover I., Koehler T., Bajnok L., Marton Z., Laszlo Z., Noori E., Veress G., Fogarassy G., Aradi D., Kelemen B., Vertes A., Davidovits Z., Zsary A., Kis E., Hepp T., Koranyi L., Peterfai E., Bezzegh K., Bakai J., Agardi I., Boda Z., Razso K., Poor F., Varallyay Z., Jarai Z., Sallai L., Dudas M., Barton J., Mahmood K., Makki H., McAdam B., Salim T., Murphy A., Crean P., Liddy A. M., Mahon N., Khan I., Hassan S., Curtin R., McFadden E., MacNeill B., Kyvelou S., Canavan M., Veerasingam D., Dinneen S., Halabi M., Rosenfeld I., Levinas T., Goldberg A., Khateeb A., Zimlichman R., Ben-Aharon J., Beniashvili A., Betsalel A., Zeltser D., Rogowski O., Mardi T., Rozenbaum Z., Turgeman Y., Or T., Rabkin Y., Klainman E., Halabi S., Halon D. A., Katz A., Plaev T., Drogenikov T., Atar S., Kilimnik M., Wishniak A., Merei M., Zvi Y., Nikolsky E., Zukermann R., Petcherski S., Bosi S., Gaitani S., Naldi M., Barbieri A., Faggiano P., Guidetti F., Adamo M., D'Aloia A., Magatelli M., Robba D., Mos L., Vriz O., Sinagra G., Maras P., Doimo S., Cosmi F., D'Orazio S., Oltrona Visconti L., Leonardi S., Vullo E., Sbaffi A., Azzara G., Mauri S., Gianni U., De Matteis C., Campidonico U., Di Pasquale G., Di Niro M., Riva L., Filippini E., Di Biase M., Ieva R., Martone A., Mandorla S., Regni O., Capponi E. A., Martinelli S., Bernardinangeli M., Proietti G., Piccinni G. C., Gualtieri M. R., Gulizia M. M., Francese G. M., Portale A., Galvani M., Ottani F., Capatano O. G., Conficoni E., Longhi S., Bachetti C., Venturi F., Capati E., Morocutti G., Bisceglia T., Fresco C., Baldin M. G., Gamba C., Olivieri C., Perna G. P., Battistoni I., Marini M., Cirrincione V., Ingrilli F., Kanno T., Ishii Y., Kohmura C., Igawa T., Izawa K., Daida H., Miyauchi K., Shimada K., Ohmura H., Ito S., Okazaki S., Konishi H., Miyazaki T., Hiki M., Kurata T., Suzuki H., Morimoto R., Yokoyama M., Yamamoto T., Okai I., Isoda K., Fujimoto S., Dohi T., Shimada A., Ozaki Y., Watanabe E., Kawai H., Naruse H., Takada K., Okuda K., Okumura M., Ishikawa M., Ohtsuki M., Ohta M., Sarai M., Koshikawa M., Kawai M., Miyagi M., Motoyama S., Matsui S., Ichikawa T., Kato Y., Nagahara Y., Muramatsu T., Hashimoto Y., Hoshino N., Harada M., Yamada A., Yoshiki Y., Motoike Y., Nomura Y., Miyajima K., Takatsu H., Nishimura H., Nagasaka R., Kawada Y., Miyamoto N., Seki K., Inoue A., Higashiue S., Kojima S., Kuroyanagi S., Furuya O., Komooka M., Yamamoto S., Wakabayashi N., Domae H., Ata T., Hashidomi H., Kawahara R., Hosokawa S., Hiasa Y., Otani R., Kishi K., Takahashi T., Yuba K., Miyajima H., Tobetto Y., Yoneda K., Ogura R., Kobayashi H., Takamura T., Enkou K., Ochi Y., Yamada D., Kuramochi T., Misumi K., Iiduka D., Hirose M., Tone K., Taniguchi Y., Ebihara T., Makino M., Yokota M., Nitta M., Udo A., Shimizu S., Fujii K., Iwakura K., Okamura A., Inoue K., Nagai H., Hirao Y., Tanaka K., Tanaka N., Yamasaki T., Oka T., Iwamoto M., Tanaka T., Nakamaru R., Okada M., Takayasu K., Sumiyoshi A., Inoue H., Kitagaki R., Ninomiya Y., Mizutomi K., Koizumi I., Funada A., Tagawa S., Kamide S., Saku K., Ideishi M., Ogawa M., Uehara Y., Iwata A., Nishikawa H., Ike A., Sugihara M., Imaizumi S., Fujimi K., Kawamura A., Sako H., Morito N., Morii J., Fukuda Y., Yahiro E., Matsunaga A., Matsumoto N., Noda K., Shiga Y., Nagata Y., Kimura K., Ebina T., Hibi K., Iwahashi N., Maejima N., Konishi M., Matsushita K., Minamimoto Y., Kawashima C., Nakahashi H., Kimura Y., Takahashi H., Matsuzawa Y., Kirigaya J., Sato R., Kikuchi S., Ogino Y., Kirigaya H., Kashiwase K., Hirata A., Takeda Y., Amiya R., Higuchi Y., Sakaguchi T., Nakano T., Matsusaki N., Suzuki S., Hayashi T., Nakatani S., Koide M., Kobayashi T., Hamanaka Y., Makino N., Sotomi Y., Abe M., Fujieda H., Hashimoto K., Teratani Y., Abe Y., Yokoyama Y., Higashino H., Okuda H., Yamazato M., Noda T., Arai M., Ono K., Hirose T., Iwama M., Warita S., Goto Y., Abe S., Kojima T., Yoshizane T., Tanihata S., Fujii T., Yagasaki H., Miwa H., Ishiguro M., Kato T., Watanabe R., Horio S., Mita T., Hirayama A., Watanabe I., Hiro T., Nakai T., Takayama T., Yoda S., Yajima Y., Okubo K., Okumura Y., Kato M., Fukamachi D., Aizawa Y., Sonoda K., Iida K., Sasaki N., Iso K., Takahashi K., Kougo T., Haruta H., Kurokawa S., Mano H., Nagashima K., Onaka H., Doi H., Hirano N., Okamoto F., Mori K., Ri G., Zushi R., Otsuka K., Inoko M., Haruna T., Nakane E., Miyamoto S., Izumi T., Honjo S., Ikeda H., Wada Y., Funasako M., Hayashi H., Hamasaki A., Sasaki K., Seko Y., Nakasone K., Hanyu M., Iwasaki Y., Iwasaki K., Ayano S., Hirokami M., Omoto Y., Sasaki H., Sato H., Yuda S., Okubo M., Matsuo H., Tsuchiya K., Kawase Y., Miyake T., Kondo H., Hattori A., Kikuchi J., Okamoto S., Hirata T., Kawamura I., Ota H., Omori H., Tanigaki T., Kamiya H., Sobue Y., Komoda T., Akatsuka Y., Yamamoto M., Isegawa K., Takanezawa M., Kataoka C., Imamaki M., Shibata Y., Yasuda K., Shimano M., Ozaki R., Morishita Y., Okabe K., Kondo K., Miura A., Manita M., Tabata K., Asahi T., Mashidori T., Higa N., Nakata M., Himi T., Matsudo Y., Sekine T., Hou K., Tonoike N., Hama Y., Tanaka S., Ge B., Takahara M., Ishimura M., Shikada T., Ueno H., Amemiya H., Hisamatsu Y., Sada K., Sato T., Harada K., Nakamura T., Ako J., Tojo T., Shimohama T., Kishihara J., Ishii S., Fukaya H., Meguro K., Nishino Y., Inoue M., Matsui Y., Omura Y., Kawakami H., Matsuoka H., Oshita A., Seike F., Kondo N., Miyoshi T., Yamada Y., Uchiya T., Kikuchi Y., Koretsune Y., Abe H., Shinouchi K., Nishida H., Yasumura K., Date M., Ueda Y., Iida Y., Idemoto A., Toriyama C., Yokoi K., Mishima T., Yamada T., Fukunami M., Morita T., Furukawa Y., Kawasaki M., Kikuchi A., Tamaki S., Seo M., Shirakawa Y., Ikeda I., Fukuhara E., Kawai T., Kayama K., Kawahira M., Tanabe K., Nakamura J., Shimomura H., Kudo T., Morisaki S., Ogura Y., Chazono N., Onoue Y., Matsumuro Y., Shirakawa T., Nishi M., Kinoshita N., Nakamura R., Miyai N., Ohta K., Sawanishi T., Takahashi A., Hada T., Nakajima S., Taniguchi N., Mizuguchi Y., Takahashi Y., Hashimoto S., Machida M., Hirabayashi K., Morimoto S., Higashino Y., Otsuji S., Takiuchi S., Yabuki M., Hasegawa K., Shishikura D., Ibuki M., Ishibuchi K., Nagayama S., Ishii R., Tamaru H., Yamamoto W., Utsu N., Miyakoshi K., Nakashima D., Tsukuda K., Ueda K., Nakano A., Fukuda T., Ikeda S., Tsuchiya H., Toshima S., Tateno R., Ishikubo T., Suguta M., Nakamura S., Funatsu A., Mizobuchi M., Tanaka M., Nagai T., Hirano S., Hashimoto T., Doi T., Shirasaka A., Takeda S., Sasaki Y., Ohya H., Hosokawa A., Nishina N., Koki B., Ando K., Hiramori S., Soga Y., Tomoi Y., Tohoku S., Shirai S., Hyodo M., Isotani A., Domei T., Kuramitsu S., Morinaga T., Hayashi M., Hiromasa T., Nagae A., Yamaji Y., Nakao K., Sakamoto T., Taguchi E., Tsurugi T., Tanaka Y., Suzuyama H., Koyama J., Nagano M., Okamatsu H., Kodama K., Nakamura M., Horibata Y., Sone M., Tsunemori M., Bando M., Nakayama T., Tanigaito Y., Nomoto M., Sawamura T., Unoki T., Lim C. W., Zainal Rashid R., Najme Khir R., Ibrahim K. S., Wan Azman W. A., Sridhar G. S., Watson T., Abu Kassim Z., Mahmood Zuhdi A. S., Abdul Hafidz M. I., Abu Hassan M. R., Wan Rahimi Shah W. F., Karthikesan D., Mohd Suan M. A., Md Ali S. M., Kasim S., Mohd Arshad M. K., Ismail J. R., Ibrahim Z. O., Chua NYL., Abdul Rahim A. A., Rusani B. I., Yap L. B., Zamrin D. M., Amir M. A., Ismail N. I., Mohammad Razi A. A., Prins F., Bendermacher P., Burg M., Lok D., van der Sluis A., Martens F., Badings E., Milhous J., van Rossum P., Viergever E., van Hessen M., Willems F., Tjon Joe Gin R., Swart H., Oomen A., Kromhout S., Lauwerijssen I., Daalmans M., Breedveld R., De Vries K., Feenema Aardema M., Hofma S., Van Der Borgh R., van Nes E., Gobel E., Oei F., Dorman H., Bos R., Zoet-Nugteren S., Emans M., Kragten H., Lenderink T., Feld R., Herrman J., Van Bergen P., Gosselink M., Elvan A., Hoekstra E., The S., de Vries R., Zegers E., Oude Ophuis T., Remmen J., Bech J., Kooistra J., Den Hartog F., Oosterhof T., Bartels G., Posma J., Nierop P., Liem A., Van Der Zwaan C., Asselman M., Van Eck J., Gevers R., Van Gorselen E., van Hal J., Terpstra W., Groenemeijer B., Jerzewski A., Hoogslag P., Geertman J., De Groot M., Dijkstra B., Loyola A., Sulit D., Mercado M. J., Rey N., Evangelista L., Abola M., Padua L., Morales D., Palomares E., Abat M., Santos R., Rogelio G., Chua P., Baello R., Del Pilar J., Alianza M., Alcaraz J., Alcaraz L., Ebo G., Guido-Saliot I., Tirador L., Estoce E., Ygpuara M., Cruz J., Anonuevo J., Pitargue A., Janion M., Drewniak Z., Guzik B., Nowak M., Nosal M., Niewiara L., Gajos G., Bury K., Czubek U., Misztal M., Grzybczak R., Zalewski J., Kruszelnicka-Kwiatkowska O., Zabowka M., Rynkiewicz A., Grzybowski A., Szalkowski P., Broncel M., Gorzelak P., Mozdzan M., Olszewska Banaszczyk M., Szuba A., Tabin M., Chachaj A., Czarnecka D., Terlecki M., Klocek M., Maga P., Coman I., Tarlea M., Ghionea M., Gavrila C., Dimulescu D., Popescu A., Stoicescu C., Vintila V., Florescu M., Baghilovici Cretu D., Suran M., Mihalcea D., Lungeanu Juravle L., Cinteza M., Calin I., Bicescu G., Vasile Toma N., Udroiu C., Gherghinescu C., Darabont R., Patrascu N., Constantinescu C., Popescu I., Sinescu C., Andrei C., Axente L., Arsenescu C., Statescu C., Ardeleanu I., Anghel L., Benedek I., Benedek T., Kinga P., Banga D. 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G., Crljenica C., Dovgan N., Skarzhevskyi O., Kozhukhov S., Tseluyko V., Mishchuk N., Kuznetsov I., Semenikhin S., Matviichuk N., Matuzok O., Yakovleva L., Volkov V., Zaprovalna O., Serik S., Riabukha V., Koval O., Kaplan P., Ivanov A., Romanenko S., Skoromna A., Kononenko L., Saprychova L., Lazareva S., Prokhorov O., Vdovychenko V., Bychkov M., Demydova A., Kapustynska O., Bazylevych A., Dutka R., Vlasyuk Z., Shabat M., Rudenko L., Beregova O., Fedtchouk L., Gusak I., Vizir V., Sadomov A., Shkolovoy V., Nasonenko O., Demidenko O., Karpenko O., Ponomarenko K., Oryshych G., Nevolina I., Mitskevych L., Bezuglova S., Kizim S., Todoriuk L., Brodi N., Karpenko L., Malynovsky Y., Fedotov S., Malynovska O., Goydenko O., Miroshnykov S., Rabota I., Koval V., Ohirko O., Khaba U., Storozhuk B., Danylchuk I., Danylchuk A., Gutsuliak R., Cotton J., Luckraz H., Wrigley B., Venkataraman A., Maher A., Moriarty A., McEneaney D., Connolly D., Davis R., Banerjee P., Davey P., Elmahi E., Senior R., Ahmed A., Birdi I., Gedela S., Singh A., Calvert J., Butler M., Donnelly P., Jasinka A., Orr C., Trevelyan J., Routledge H., Carter J., Oxenham H., Peace A., McNeill A., Austin D., Jackson M., Kukreja N., Kotwinski P., Hilton T., Bilizarian S., Srivastava S., Walsh R., Fields R., Portnay E., Gogia H., Deits R., Salacata A., Hunter J., Bacharach J., Shammas N., Suresh D., Gurbel P., Banerjee S., Grena P., Bedwell N., Sloan S., Lupovitch S., Soni A., Gibson K., Pepper D., Sangrigoli R., Mehta R., Patel J., I-Hsuan Tsai P., Gillespie E., Harrison A., Dempsey S., Phillips R., Hamroff G., Hametz C., Black R., Lader E., Kostis J., Bittner V., Mcguinn W., Cheng R., Pal J., Malhotra V., Michaelson S., Vacante M., Mccormick M., Arimie R., Dukkipati R., Camp A., Dagher G., Kosh y N., Culp J., Thew S., Ferraro A., Costello F., Heiman M., Chilton R., Moran M., Adler F., Balingit P., Comerota A., Seiwert A., French W., Vardi G., Singh T., Serota H., Qayyum U., Das S., Harrison R., Vora A., Bakeen F., Omer S., Chandra L., Casaccia G., Tinto J., Sighel C., Giozzi E., Morell Y., Bianchini M., Yossen M., Hoyos M., Venturini C., Merkusa C., Carrique A., Carrique P., Fracaro V., Torres M., Crunger P., Espinosa M., Passarello A., Zaidman M., Ledesma M., Troncoso C., Aviles A., Rodera Vigil S., Vogel M., Takla M., Funosas C., Ferreiro M., Bruno T., Buzzetti C., Lozano J., Alvarez Damelio A., Bocanera M., Vicente D., Cenci A., Deluca C., Santana R., Ahuad Calvelo A., Alvarez D'Amelio A., Ahuad Calvelo J., Herrero S., Robertson M., Tapia D., Escalante M., Canas M., Cendali G., Esposito L., Muniz M., Montana J., Di Vruno M., Strevezza M., Lopez Santi M., Massei N., Garate V., Perlo D., Campora F., Jakubowski I., Gonzalez Moisello M., Actis M., Schiavi S., Aguirre M., Ceirano C., Zillo M., Yunis M., Berdini A., Gerbaudo R., Berdini J., Palma F., Pinero S., Virulio S., Vitale A., Sosa Flores G., Ibanez Saggia C., Ibanez Saggia D., Roses A., Martinelli C., Vargas L., Galarza Salazan M., Dran P., Tinnirello V., Pelayes S., Bordoni P., Navarro A., Barilati P., Serra R., Nigro A., Cleiman S., Bianchi M., Vallejo M., Ingratta M., Tonelli L., Levantini M., Bonifacio M., Hansen V., Chaieb A., Majul S., Medina F., Gallinotti P., Madariaga T., Andrea G., Blumberg C., Volpe M., Gandur H., Benincasa V., Barreto M., Jure D., Tulloch G., Greenwell D., Forrest N., Nyman E., Mcintosh C., O'May V., Grabek T., Conway B., O'Donoghue M., Brady L., Duroux M., Ratcliffe M., Shone S., Connelly A., Ferreira-Jardim A., Vandernet R., Downes R., Davids F., Teal L., Knight S., Soraghan D., Spence C., Smith K., Tivendale L., Williams Z., O'Connor M., Walker I., Ferguson L., Holiday J., Griffin R., Palethorpe L., Hindom L., Lilwall L., Wadham S., Narasimhan K., Van Extergem P., Joris I., Oreglia M., Jacobs C., Leus W., Robesyn V., Vanheule K., Van Den Bossche K., Albertijn S., Vissers C., Badts G., Vangenechten K., Derycker K., Dejaegher K., De Grande T., De Clippel M., Gayet F., Jorion M., Jourdan A., Tartaglia K., Zwinnen W., Roijakkers I., Van Genechten G., Schoonis A., Bollen J., Janssen A., De Coninck M., Ruell S., Grimonprez A., Bouckaert N., Van Eeckhoutte H., Malmendier D., Massoz M., Jacquet S., Vanhalst E., Casier T., Barroso S. 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T., MCamasmie P., Assompcao R. P., Marques L. L., Leung S., Lewis C., Tytus A., Clarus S., Juranics S., Pandey M., Frenette L., Magi A., Nowacki B., Otis J., Fox B., Corke R., Miller B., Rizzo A., Trombetta L., Power P., Richert L., Haligowski R., Macrae C., Kooistra L., Urso C., Fox S., Felbel S., Stafford C., Stata C., Barnabe B., Mehta K., Faul J., Gohel J., Bhakta S., Harwood A., McPherson C., Marucci J., Manasterski L., Veenhuyzen J., Ramadan D., Madden B., Jetha A., Pajevic M., Dube C., Rolfe B., O'Blenis G., Roy L., Dihel C., Butler J., Simmavong K., Bartol C., Bozek B., Hart B., Shier M., Coughlin M., Lamantia C., Lamantia D., Vilag C., Fecteau J., Dionne J., Peloquin G., Hogg N., Welsh S., Weerasingam S., Lantz M., Lounsbury N., Martin E., Mitchell L., Morgen G., Nelson S., Pelzer E., Sorensen S., LeBlanc A., Bourlaud A. S., Premont A., Leger P., Lariviere M. 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T., Abatello M., De Tora M., Pietrucci F., Pezzetta S., Chiminelli E., Dall'Asta A., Bennati M., Elia A., Bizzoco M., Iaquaniello A., Spigarelli R., Cremonesi C., Gagliardi M., Torricelli L., Ijichi N., Shiraiwa K., Murakami M., Takeshita K., Sato M., Shiratori A., Kinjo K., Tomita K., Mizuno M., Kurihara F., Tachibana M., Nitta Y., Unno K., Hiramatsu H., Sano A., Nanatsumura M., Tanikawa I., Uesugi K., Banno S., Miyata T., Kujuji A., Kawai K., Maegawa A., Koseki T., Watanabe Y., Aoki S., Maesawa M., Suzuki A., Itose Y., Konishi K., Fujieda K., Nakade S., Minami M., Yoneda J., Akiyama R., Sakai S., Nakatani K., Yamazaki A., Funama M., Kaneko E., Morii S., Onishi M., Sone A., Sagawa N., Iwai F., Kawahara A., Hasimoto C., Ueki M., Kamiji M., Ando M., Yokoo M., Okada Y., Yamada H., Matsushige N., Nagato A., Matsumoto R., Nishikawa M., Oka I., Kitou S., Tachiuchi M., Nakagawa M., Yoneda S., Iwasa K., Matsuda J., Oda A., Tokudome S., Kaneyuki Y., Higaki M., Yoneda H., Kajita C., Suwa K., Sato E., Nagata T., Kubo Y., Umesu A., Ohashi K., Takeuchi M., Tanaka I., Nobehara T., Yamano R., Yumiba A., Hamada M., Nishihata T., Ohashi Y., Morita M., Endo M., Matsugi M., Tateishi H., Nakamori R., Yamashita Y., Okabe M., Matsuo M., Ono T., Shigeyama Y., Ichiyanagi M., Sugimori K., Ohmura C., Igarashi M., Aotsuka S., Komoda N., Watanabe M., Enomoto Y., Suzuki Y., Kawaguchi A., Kasahara A., Koide A., Sakatani T., Kurihara T., Yokota S., Futagi R., Amemiya Y., Ono E., Maeda A., Kadono K., Ishiguchi Y., Kikuchi R., Kuramatsu M., Nakamura E., Chiba S., Higa A., Kitahashi M., Tanaka H., Ito T., Oba M., Tsubouchi M., Toshima M., Morishita M., Miyano A., Kondo M., Watanabe K., Shibata R., Tosaki Y., Ito Y., Saoda M., Yamasaki E., Kadosaki S., Motooka S., Akiyoshi H., Morio S., Nemoto H., Yoshizawa S., Okabe N., Semba K., Yoshida A., Lee Y., Yoshida M., Iwashita Y., Takeda A., Maezato M., Kawahira K., Yoshikawa M., Okamoto N., Nishimura M., Matsuura K., Fukunaga M., Fukai K., Osakabe Y., Yamamura K., Koike M., Shibuya S., Shiramata M., Ono Y., Tsujimoto Y., Tadokoro T., Morishita N., Matsuo Y., Yumoto I., Sakazaki S., Atarashi A., Nabata Y., Okuda N., Fujita A., Matsuo A., Ishizawa Y., Shibata H., Ootsuka M., Taimatsu R., Takeuchi A., Sumi Y., Yamamoto F., Araki Y., Tanaka A., Kuroda S., Sakata R., Okada N., Sawada Y., Miyata M., Asayama H., Koga N., Miki T., Yamaguchi N., Hashimoto A., Fukuike C., Kubo A., Yamasaki M., Mori Y., Nakayama S., Kobayashi Y., Takenaka S., Mashima M., Katsuta H., Matsumura T., Yanagida S., Watanabe N., Kodama S., Kusano M., Yamamoto N., Kamada R., Suzuki K., Itami K., Hasebe Y., Fujita N., Kubota S., Usuki A., Okamoto M., Uno S., Chikuma A., Kishikawa H., Yano K Nakano C., Otaguro M., Kayashima Y., Shinoda M., Jaafar S. 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S., Rutten R., Rademaker H., Van Buijsen M., Scholten M., Stuij S., van Zeijst M., van Houwelingen K., Engelen W., Kramer H., Maassen E., Verhoeven P., Awater J., Terwisscha van Scheltinga C., Meijlis P., Blom L., Bos M., van der Wal M., Van Laerhoven G., Jacobs T., Tan-Urgert B., Van de Gaag J., Den Boer P., Verlek E., Lardinois R., Coenjaerds C., Hendrick R., Schoep J., Froma E., van Nes C., Beuving D., Krikken J., Drent I., Geerlings F., Buvelot S., Wissenburg A., Dijkshoorn A., van Setten van der Meer L., Singerling M., Van Wijk D., Bor A., Aukema-Wouda Z., Hendriks-van Woerden M., Kort I., Danse I., van der Knaap M., de Jong C., Temminck M., Schaefer T., Van der Ven N., Drost I., Mulder R., De Vos A., de Hoop M., Post G., Wielandt D., Edorot N., De Castro K., Flotildes M., Mulingtapang T., Vasquez S., Facundo S., Peralta M., Jose M., Bandiez J., Sulit P., Joaquin F., Arbis M. G., Silva C., Delgado D., De Leon R., Maglasang P., Sian A., Alagban C., Alcorano J., Marcelo M. J., Dela Pena C., Hyra I., Malkiewicz B., Mosakowska K., Cana I., Dobrin I., Lautaru A., Manescu G., Samoila N., Lacatus M., Apostoie A., Prunoiu M., Tilinca M., Budeanu A., Nedelcu C., Dumitrache N., Boeru L., Zhuravleva E., Gundova M., Hoffmannova J., Svitkova M., Pekarova T., Ujacka K., Zsoriova T., Kubincova K., Jankovicova Z., Talliard C., Tyumbu N., Mngoma N., Kannemeyer M., Mostert J., Page A., Krahenbuhl C., Tredoux C., Hendricks L., Oliver S., Le Grange M., Naidoo V., Bae Y., Kim H., Lee J., Yu N., An S., Kim E., Yang K., Woo J., Kim S., Rasck J., Smetana S., Ajax K., Bylander L., Lindberg A., Dellborg H., Hultsberg-Olsson G., Harsmar K., Knutsson A., Hakansson L., Kaveryd-Holmstrom M., Lundmark L. M., Norrfors B., Lof P., Skoglund K., Torgersruud M., Johansson K., Mattsson A., Quist M., Haglund P., Lundell L., Gunvasdotter S., Rangman B., Liu R., Shi J., Forstedt G., Nylund L., Welin-Berger B., Nilsson O., Garcia-Varlid A., Forlenza R., Kaminska K., Nagorna T., Cottam V., Harper R., Gilchrist M., Musanhu R., Mackin A., Turner A., Willetts S., Cadd A., Evans J., Young G., Sevillano A., Brodie K., Eccles A., Kelly S., Doughty A., Gray J., Gibson M., Finlayson M., Domingo D., Brazee L., Renaud K., Doman A., Meyer R., Beatty J., Morgan T., Rodas E., Campbell D., Mcquarrie M., Battistelli E., Eisenbraun P., Farley R., Park H., Dwyer J., Adams K., Schneider W., Barbour C., Whyne E., Budzinski S., Craig M., Gilley Elmore J., Scott D., Bellini S., Pepper M., Gunderson K., Stipek I., Schwarz L., Watkins K., Moore V., Palao A., Keane-Richmond P., Franklin L., Ward L., Kostedt G., Bailey S., Hollenweger L., Solomon A., Johnson D., Gloer K., Meyer M., Boleyn M., Nieters D., Humphrey K., Bohn A., Mueller G., Mckenzie H., Edwards T., Velky J., Cole C., Diederick M., Burg S., Coulson T., Karunaratne K., Gunasekera R., Cook S., Fisher S., Garrison K., Passey L., Kuykendall K., Luck K., Ramia, Joan H., Reynoso F., Farley M., Shuman S., Santana-Fernandes E., Ventimiglia A., Steele V., Gers L., Brown P., Wilson J., Freebersyser J., Reno M., Buettner N., Mcgovern M., Hubbard T., Elmore H., Payne D., Mccann M., Decker S., Sharp A., Forgey E., Broussard E., Juett U., Siddiqui A.

المساهمون: Eikelboom, J. W., Connolly, S. J., Bosch, J., Dagenais, G. R., Hart, R. G., Shestakovska, O., Diaz, R., Alings, M., Lonn, E. M., Anand, S. S., Widimsky, P., Hori, M., Avezum, A., Piegas, L. S., Branch, K. R. H., Probstfield, J., Bhatt, D. L., Zhu, J., Liang, Y., Maggioni, A. P., Lopez-Jaramillo, P., O'Donnell, M., Kakkar, A. K., Fox, K. A. A., Parkhomenko, A. N., Ertl, G., Stork, S., Keltai, M., Ryden, L., Pogosova, N., Dans, A. L., Lanas, F., Commerford, P. J., Torp-Pedersen, C., Guzik, T. J., Verhamme, P. B., Vinereanu, D., Kim, J. -H., Tonkin, A. M., Lewis, B. S., Felix, C., Yusoff, K., Steg, P. G., Metsarinne, K. P., Bruns, N. C., Misselwitz, F., Chen, E., Leong, D., Yusuf, S., Aboyans, V., Ha, J., Keltai, K., Lamy, A., Liu, L., Moayyedi, P., Sharma, M., Stoerk, S., Varigos, J., Bhagirath, V., Bogaty, P., Botto, F., Catanese, L., Donato Magno, J., Fabbri, G., Gabizon, I., Gosselin, G., Halon, D., Heldmann, M., Lamelas, P., Lauw, M., Leong, Y., Liang, D., Lutay, Y., Maly, M., Mikulik, R., Nayar, S., Ng, K., Perera, K., Pirvu, O., Ronner, E., Sato, S., Smyth, A., Sokolova, E., Wiendl, M., Winkelmann, B., Yang, X., Yufereva, Y., Cairns, J., Sleight, P., Demets, D., Momomura, S. I., Prins, M., Ramsay, T., Goto, S., Rouleau, J. L., Schumi, J., Thabane, L., Casanova, A., Bangdiwala, S., Deng, E.

مصطلحات موضوعية: Aged, Aspirin, Atherosclerosi, Cardiovascular Disease, Double-Blind Method, Drug Therapy, Combination, Factor Xa Inhibitor, Female, Hemorrhage, Human, Male, Middle Aged, Platelet Aggregation Inhibitor, Rivaroxaban, Secondary Prevention

الوصف: BACKGROUND: We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. METHODS: In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). The primary outcome was a composite of cardiovascular death, stroke, or myocardial infarction. The study was stopped for superiority of the rivaroxaban-plus-aspirin group after a mean follow-up of 23 months. RESULTS: The primary outcome occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (379 patients [4.1%] vs. 496 patients [5.4%]; hazard ratio, 0.76; 95% confidence interval [CI], 0.66 to 0.86; P<0.001; z=−4.126), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (288 patients [3.1%] vs. 170 patients [1.9%]; hazard ratio, 1.70; 95% CI, 1.40 to 2.05; P<0.001). There was no significant difference in intracranial or fatal bleeding between these two groups. There were 313 deaths (3.4%) in the rivaroxaban-plus-aspirin group as compared with 378 (4.1%) in the aspirin-alone group (hazard ratio, 0.82; 95% CI, 0.71 to 0.96; P=0.01; threshold P value for significance, 0.0025). The primary outcome did not occur in significantly fewer patients in the rivaroxaban-alone group than in the aspirin-alone group, but major bleeding events occurred in more patients in the rivaroxaban-alone group. CONCLUSIONS: Among patients with stable atherosclerotic vascular disease, those assigned to rivaroxaban (2.5 mg twice daily) plus aspirin had better cardiovascular outcomes and more major bleeding events than those assigned to aspirin alone. Rivaroxaban (5 mg twice daily) alone did not result in better cardiovascular outcomes than aspirin alone and resulted in more major bleeding events.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28844192; info:eu-repo/semantics/altIdentifier/wos/WOS:000412375000012; volume:377; issue:14; firstpage:1319; lastpage:1330; numberofpages:12; journal:NEW ENGLAND JOURNAL OF MEDICINE; http://hdl.handle.net/11571/1342929Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85029804845

الإتاحة: https://doi.org/10.1056/NEJMoa1709118Test
http://hdl.handle.net/11571/1342929Test

المؤلفون: Parving, Hh, Brenner, Bm, Mcmurray, Jj, de Zeeuw, D, Haffner, Sm, Solomon, Sd, Chaturvedi, N, Persson, F, Desai, As, Nicolaides, M, Richard, A, Xiang, Z, Brunel, P, Pfeffer, Ma, Viberti, G, Lachin, Jm, Zinman, B, Pedersen, Tr, Villamil, As, Juncos, L, Prager, R, Verpooten, G, Zanella, Mt, Leiter, L, Pan, C, Wang, H, Botero, R, Cifkova, R, Christiansen, Js, Groop, Ph, Marre, M, Haller, H, Nickenig, G, Siamopoulos, K, Gero, L, Maggioni, A, Remuzzi, G, Katayama, Ss, Kim, Sg, Petrulioniene, Z, Lok, D, Kooy, A, Jorde, R, Medina, F, Polonia, J, Wong, Ks, Dukat, A, Rayner, Bl, Ruilope, L, Weiss, L, Wuethrich, R, Sheu, W, Sritara, P, Comlekci, A, Bilous, R, Toto, R, Jamerson, K, Carillo, E, Orias, M, Kuschnir, E, Rusculleda, M, Garcia, S, Farias, E, Lema, L, Hominal, M, Montaña, O, Sala, J, Diaz, M, Piskorz, D, Vita, N, Litwak, L, Sinay, I, Marin, M, Massari, P, Majul, C, Aizemberg, D, Azize, Gm, Bartolacci, I, Reboredo, A, Vico, M, Milesi, R, Sessa, H, Wassermann, A, Margulis, F, Zangroniz, P, Watschinger, B, Toplak, H, Paulweber, B, Drexel, H, Francesconi, C, Foeger, B, Mayer, G, Braun, Rk, Brath, H, Gaal, Lv, Niepen, Pv, Persu, A, Vercammen, C, Vriese, Ad, Coucke, F, Mathieu, C, Fery, F, Treille, S, Meeus, G, Acker, Kv, Scheen, A, Tits, J, Ruige, J, Krzesinski, Jm, Hollanders, G, Liénart, F, Dendale, P, Quinonez, M, Arnouts, P, Vanuytsel, J, Zanella, M, Mion D., Jr, Forti, A, Almeida, F, Cunha, R, de Paula RB, Brandao, A, Rocha, J, Krieger, E, Feitosa, G, Saraiva, J, Martin, J, Hissa, Mn, Schmid, H, Felicio, J, Sgarbi, J, Oigman, W, Bowering, K, Garceau, C, Berlingieri, Jc, Weisnagel, Sj, Hardin, P, Powell, C, Turcot, R, Muirhead, N, Aronson, R, Barima, Yt, Steele, Aw, Pandey, S, Woo, V, Cha, J, Dattani, D, Godin, C, Gupta, M, Saunders, K, Tellier, G, Ting, R, Tobe, S, Chouinard, G, Schlosser, R, Khandwala, H, Ekoe, Jm, Harris, Sb, Pichette, V, Lachance, P, Ooi, Tc, Tildesley, H, Barrett, B, Cournoyer, S, Lu, J, Zhang, H, Liu, X, Yan, S, Qi, X, Li, Q, Li, H, 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المساهمون: Groningen Kidney Center (GKC)

المصدر: Parving, Hans-Henrik; Brenner, Barry M.; McMurray, John J.V.; de Zeeuw, Dick; Haffner, Steven M.; Solomon, Scott D.; Chaturvedi, Nish; Persson, Frederik; Desai, Akshay S.; Nicolaides, Maria; Richard, Alexia; Xiang, Zhihua; Brunel, Patrick; Pfeffer, Marc A.; for the ALTITUDE, incl.; Allemann, Yves (2012). Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes. New England journal of medicine NEJM, 367(23), pp. 2204-2213. Waltham, Mass.: Massachusetts Medical Society MMS 10.1056/NEJMoa1208799 <http://dx.doi.org/10.1056/NEJMoa1208799Test>
NEW ENGLAND JOURNAL OF MEDICINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
New England Journal of Medicine, 367(23), 2204-2213. MASSACHUSETTS MEDICAL SOC
Parving, H-H, Brenner, B M, McMurray, J J V, de Zeeuw, D, Haffner, S M, Solomon, S D, Chaturvedi, N, Persson, F, Desai, A S, Nicolaides, M, Richard, A, Xiang, Z, Brunel, P, Pfeffer, M A & ALTITUDE Investigators 2012, ' Cardiorenal end points in a trial of aliskiren for type 2 diabetes ', Briefings from the New England Journal of Medicine (Spanish Edition), vol. 367, no. 23, pp. 2204-13 . https://doi.org/10.1056/NEJMoa1208799Test

مصطلحات موضوعية: Male, Hyperkalemia, CARDIOVASCULAR MORTALITY, BLOOD-PRESSURE, Angiotensin-Converting Enzyme Inhibitors, Type 2 diabetes, GLOMERULAR-FILTRATION-RATE, DOUBLE-BLIND, chemistry.chemical_compound, Fumarates, cardiovascular disease, Renin, Treatment Failure, Settore MED/49 - Scienze Tecniche Dietetiche Applicate, 610 Medicine & health, diabetes, Medicine (all), Hazard ratio, aliskiren, diabete, trial clinico, Liter, General Medicine, Middle Aged, hypertension, Cardiovascular Diseases, Combination, HEART-FAILURE, Drug Therapy, Combination, Female, Kidney Diseases, type 2 diabetes, medicine.symptom, Type 2, medicine.medical_specialty, Patient Dropouts, Urology, Hypokalemia, Aliskiren, chronic kidney disease, Placebo, Angiotensin Receptor Antagonists, LEFT-VENTRICULAR DYSFUNCTION, Drug Therapy, Double-Blind Method, Diabetes Mellitus, medicine, Humans, CONVERTING-ENZYME INHIBITORS, Antihypertensive Agents, Aged, Amides, Diabetes Mellitus, Type 2, Follow-Up Studies, business.industry, medicine.disease, Confidence interval, Surgery, Blood pressure, MYOCARDIAL-INFARCTION, chemistry, SYSTOLIC DYSFUNCTION, FOLLOW-UP, business

الوصف: BACKGROUND This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both. METHODS In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level. RESULTS The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P = 0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pressures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, = 6 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P CONCLUSIONS The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful. (Funded by Novartis; ALTITUDE ClinicalTrials.gov number, NCT00549757.)

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