التفاصيل البيبلوغرافية
| العنوان: |
TROPiCS-02: A Phase III study investigating sacituzumab govitecan in the treatment of HR+/HER2- metastatic breast cancer. |
| المؤلفون: |
Rugo, Hope S, Bardia, Aditya, Tolaney, Sara M, Arteaga, Carlos, Cortes, Javier, Sohn, Joohyuk, Marmé, Frederik, Hong, Quan, Delaney, Rosemary J, Hafeez, Amir, André, Fabrice, Schmid, Peter |
| المصدر: |
Future Oncology; Apr2020, Vol. 16 Issue 10, p705-715, 11p |
| مصطلحات موضوعية: |
THERAPEUTIC use of immunoglobulins, THERAPEUTIC use of monoclonal antibodies, RESEARCH, IMMUNOGLOBULINS, CLINICAL trials, RESEARCH methodology, CAMPTOTHECIN, MONOCLONAL antibodies, CELL receptors, METASTASIS, EVALUATION research, MEDICAL cooperation, TUMOR classification, TREATMENT effectiveness, COMPARATIVE studies, CELL adhesion molecules, REOPERATION, DRUG therapy, TUMOR antigens, BREAST tumors, DRUG resistance in cancer cells |
| مستخلص: |
Patients with HR+/HER2- metastatic breast cancer (MBC) whose cancers have progressed despite conventional therapies represent an unmet clinical need. Trop-2, a transmembrane calcium signal transducer, is highly expressed in MBC and plays a role in tumor growth and progression. Sacituzumab govitecan (SG) is a novel antibody-drug conjugate comprising an Trop-2 antibody coupled to SN-38, the active metabolite of irinotecan, via a unique hydrolyzable linker. SG has demonstrated promising activity in a Phase I/II IMMU-132-01 basket study in heavily pretreated solid tumors, including HR+/HER2- MBC. We describe the registrational Phase III TROPiCS-02 study (NCT03901339), evaluating SG versus treatment of physician's choice in HR+/HER2- MBC. Trial registration number: NCT03901339. [ABSTRACT FROM AUTHOR] |
|
Copyright of Future Oncology is the property of Future Medicine Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
