التفاصيل البيبلوغرافية
| العنوان: |
Use of gene networks for identifying and validating drug targets |
| المؤلفون: |
Seiya Imoto, Christopher J. Savoie, Sachiyo Aburatani, Sunyong Kim, Kousuke Tashiro, Satoru Kuhara |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
http://bonsai.ims.u-tokyo.ac.jp/~imoto/imoto_jbcb2003_drug.pdfTest. |
| سنة النشر: |
2003 |
| المجموعة: |
CiteSeerX |
| مصطلحات موضوعية: |
Drug targets, gene network, microarray, Bayesian network. ∗ These authors contributed equally to this work. 459 |
| الوصف: |
We propose a new method for identifying and validating drug targets by using gene networks, which are estimated from cDNA microarray gene expression profile data. We created novel gene disruption and drug response microarray gene expression profile data libraries for the purpose of drug target elucidation. We use two types of microarray gene expression profile data for estimating gene networks and then identifying drug targets. The estimated gene networks play an essential role in understanding drug response data and this information is unattainable from clustering methods, which are the standard for gene expression analysis. In the construction of gene networks, we use the Bayesian network model. We use an actual example from analysis of the Saccharomyces cerevisiae gene expression profile data to express a concrete strategy for the application of gene network information to drug discovery. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.131.5792Test; http://bonsai.ims.u-tokyo.ac.jp/~imoto/imoto_jbcb2003_drug.pdfTest |
| الإتاحة: |
http://bonsai.ims.u-tokyo.ac.jp/~imoto/imoto_jbcb2003_drug.pdfTest |
| حقوق: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.94071D92 |
| قاعدة البيانات: |
BASE |
