التفاصيل البيبلوغرافية
| العنوان: |
Molecules promoting circulating clusters of cancer cells suggest novel therapeutic targets for treatment of metastatic cancers. |
| المؤلفون: |
Rozenberg, Julian M., Buzdin, Anton A., Mohammad, Tharaa, Rakitina, Olga A., Didych, Dmitry A., Pleshkan, Victor V., Alekseenko, Irina V. |
| المصدر: |
Frontiers in Immunology; 3/15/2023, Vol. 14, p1-17, 17p |
| مصطلحات موضوعية: |
METASTASIS, CANCER cells, DRUG target, BIOMOLECULES, OVERALL survival |
| مستخلص: |
Treatment of metastatic disease remains among the most challenging tasks in oncology. One of the early events that predicts a poor prognosis and precedes the development of metastasis is the occurrence of clusters of cancer cells in the blood flow. Moreover, the presence of heterogeneous clusters of cancerous and noncancerous cells in the circulation is even more dangerous. Review of pathological mechanisms and biological molecules directly involved in the formation and pathogenesis of the heterotypic circulating tumor cell (CTC) clusters revealed their common properties, which include increased adhesiveness, combined epithelial-mesenchymal phenotype, CTC-white blood cell interaction, and polyploidy. Several molecules involved in the heterotypic CTC interactions and their metastatic properties, including IL6R, CXCR4 and EPCAM, are targets of approved or experimental anticancer drugs. Accordingly, analysis of patient survival data from the published literature and public datasets revealed that the expression of several molecules affecting the formation of CTC clusters predicts patient survival in multiple cancer types. Thus, targeting of molecules involved in CTC heterotypic interactions might be a valuable strategy for the treatment of metastatic cancers. [ABSTRACT FROM AUTHOR] |
|
Copyright of Frontiers in Immunology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder