المؤلفون: Akhmetzhanov, Andrei R, Kim, Jong Wook, Sullivan, Ryan, Beckman, Robert A, Tamayo, Pablo, Yeang, Chen-Hsiang

مصطلحات موضوعية: Biological Sciences, Mathematical Sciences, Cancer, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Drug Resistance, Neoplasm, Humans, Melanoma, Models, Biological, Mutation, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Tumour management, Targeted treatments, Drug resistance, State transitions, Pathway regulation, Oncogenic states, Information and Computing Sciences, Evolutionary Biology, Biological sciences, Mathematical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8ch5t0zmTest

المؤلفون: Kitajima, Shunsuke, Asahina, Hajime, Chen, Ting, Guo, Sujuan, Quiceno, Laura Gutierrez, Cavanaugh, Jillian D, Merlino, Ashley A, Tange, Shoichiro, Terai, Hideki, Kim, Jong Wook, Wang, Xiaoen, Zhou, Shan, Xu, Man, Wang, Stephen, Zhu, Zehua, Thai, Tran C, Takahashi, Chiaki, Wang, Yujin, Neve, Richard, Stinson, Susanna, Tamayo, Pablo, Watanabe, Hideo, Kirschmeier, Paul T, Wong, Kwok-Kin, Barbie, David A

المصدر: Cancer Cell. 34(3)

مصطلحات موضوعية: Cancer, Lung, Lung Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, AMP-Activated Protein Kinase Kinases, AMP-Activated Protein Kinases, Adaptor Proteins, Signal Transducing, Animals, Antineoplastic Agents, Immunological, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Disease Models, Animal, Drug Resistance, Neoplasm, HEK293 Cells, Humans, Immunity, Innate, Insulin-Like Growth Factor I, Lung Neoplasms, Mice, Mice, Transgenic, Mitogen-Activated Protein Kinase Kinases, Phosphoproteins, Protein Kinase Inhibitors, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins p21(ras), Transcription Factors, YAP-Signaling Proteins, BET inhibitor, IL-6, KRAS, MEK inhibitor, STK11/LKB1, TBK1 inhibitor, TP53, YAP1 signaling, innate immune signaling, non-small-cell lung cancer, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5b758027Test

المؤلفون: Kim, Jong Wook, Botvinnik, Olga B, Abudayyeh, Omar, Birger, Chet, Rosenbluh, Joseph, Shrestha, Yashaswi, Abazeed, Mohamed E, Hammerman, Peter S, DiCara, Daniel, Konieczkowski, David J, Johannessen, Cory M, Liberzon, Arthur, Alizad-Rahvar, Amir Reza, Alexe, Gabriela, Aguirre, Andrew, Ghandi, Mahmoud, Greulich, Heidi, Vazquez, Francisca, Weir, Barbara A, Van Allen, Eliezer M, Tsherniak, Aviad, Shao, Diane D, Zack, Travis I, Noble, Michael, Getz, Gad, Beroukhim, Rameen, Garraway, Levi A, Ardakani, Masoud, Romualdi, Chiara, Sales, Gabriele, Barbie, David A, Boehm, Jesse S, Hahn, William C, Mesirov, Jill P, Tamayo, Pablo

المصدر: Nature Biotechnology. 34(5)

مصطلحات موضوعية: Biological Sciences, Biomedical and Clinical Sciences, Genetics, Cancer, Good Health and Well Being, Biomarkers, Tumor, Chromosome Mapping, Drug Resistance, Neoplasm, Genes, Neoplasm, Genetic Predisposition to Disease, Genome, Human, Genome-Wide Association Study, Humans, Mutation, Neoplasm Proteins, Neoplasms, Polymorphism, Single Nucleotide, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3zw5j2cpTest

المؤلفون: Krall, Elsa B, Wang, Belinda, Munoz, Diana M, Ilic, Nina, Raghavan, Srivatsan, Niederst, Matthew J, Yu, Kristine, Ruddy, David A, Aguirre, Andrew J, Kim, Jong Wook, Redig, Amanda J, Gainor, Justin F, Williams, Juliet A, Asara, John M, Doench, John G, Janne, Pasi A, Shaw, Alice T, McDonald III, Robert E, Engelman, Jeffrey A, Stegmeier, Frank, Schlabach, Michael R, Hahn, William C

مصطلحات موضوعية: CRISPR-Cas9, drug resistance, lung cancer, Human

وصف الملف: application/pdf

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305212/pdfTest/; eLife; Krall, E. B., B. Wang, D. M. Munoz, N. Ilic, S. Raghavan, M. J. Niederst, K. Yu, et al. 2017. “KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.” eLife 6 (1): e18970. doi:10.7554/eLife.18970. http://dx.doi.org/10.7554/eLife.18970Test.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731721Test

الإتاحة: https://doi.org/10.7554/eLife.18970Test
http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731721Test

المؤلفون: Akhmetzhanov, Andrei R.^1,2 (AUTHOR), Kim, Jong Wook^3,4,5 (AUTHOR), Sullivan, Ryan⁶ (AUTHOR), Beckman, Robert A.⁷ (AUTHOR), Tamayo, Pablo^3,4,5 (AUTHOR), Yeang, Chen-Hsiang¹ (AUTHOR) chyeang@stat.sinica.edu.tw

المصدر: Journal of Theoretical Biology. Aug2019, Vol. 474, p88-102. 15p.

مصطلحات موضوعية: *THERAPEUTICS, *POPULATION dynamics, *DRUG side effects, *OPTIMAL control theory, *BRAF genes, *PHYSIOLOGICAL adaptation, *TUMORS, *MELANOMA treatment, *DRUG resistance in cancer cells, *ANTINEOPLASTIC agents

المؤلفون: Oh, Mi Mi¹, Chae, Ji Yun¹, Kim, Jin Wook¹, Kim, Jong Wook¹, Yoon, Cheol Yong^1,2, Park, Min Gu³, Moon, Du Geon^1,2 dgmoon@korea.ac.kr

المصدر: Urology. Jun2013, Vol. 81 Issue 6, p1209-1212. 4p.

مصطلحات موضوعية: *PROSTATITIS treatment, *BETA lactamases, *DISEASE progression, *BIOPSY, *QUINOLONE antibacterial agents, *DRUG resistance

المؤلفون: Elsa Beyer Krall, Matthew J. Niederst, Belinda Wang, Jong Wook Kim, John G. Doench, Kristine Yu, Diana M Munoz, Nina Ilic, Andrew J. Aguirre, Robert E McDonald, Juliet Williams, Jeffrey A. Engelman, Srivatsan Raghavan, Frank Stegmeier, John M. Asara, Alice T. Shaw, Amanda J. Redig, Justin F. Gainor, Michael R. Schlabach, Pasi A. Jänne, David A. Ruddy, William C. Hahn

المساهمون: Broad Institute of MIT and Harvard, Wang, Belinda, Raghavan, Srivatsan, Aguirre, Andrew J., Kim, Jong Wook, Doench, John Gerard, Hahn, William

المصدر: eLife
eLife, Vol 6 (2017)

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Neuroblastoma RAS viral oncogene homolog, QH301-705.5, Science, medicine.medical_treatment, Biology, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Receptor tyrosine kinase, Targeted therapy, 03 medical and health sciences, medicine, Biology (General), Protein kinase A, drug resistance, General Immunology and Microbiology, Cell growth, Kinase, General Neuroscience, General Medicine, 3. Good health, lung cancer, 030104 developmental biology, Cancer research, biology.protein, Medicine, KRAS, CRISPR-Cas9

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dee6a2469d5a5e1fb455bb61faaecedTest
https://doi.org/10.7554/elife.18970Test

المساهمون: Wilson, Frederick H., Johannessen, Cory M., Piccioni, Federica, Tamayo, Pablo, Kim, Jong Wook, Van Allen, Eliezer M., Corsello, Steven M., Capelletti, Marzia, Calles, Antonio, Butaney, Mohit, Sharifnia, Tanaz, Gabriel, Stacey B., Mesirov, Jill P., Hahn, William C., Engelman, Jeffrey A., Meyerson, Matthew, Root, David E., Jänne, Pasi A., Garraway, Levi A.

المصدر: Cancer Cell. 2015; 27(3):397-408.

مصطلحات موضوعية: Article, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Resistance, Neoplasm, Humans, Lung Neoplasms, Pyrazoles, Pyridines, Receptor Protein-Tyrosine Kinases, Receptor, Epidermal Growth Factor, ErbB-2, Receptors, Purinergic P2Y, Signal Transduction

العلاقة: cdc:30650; http://stacks.cdc.gov/view/cdc/30650Test/

الإتاحة: http://stacks.cdc.gov/view/cdc/30650Test/