دورية أكاديمية
Antimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles
| العنوان: | Antimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles |
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| المؤلفون: | van der Weide H., Vermeulen-de Jongh D. M. C., van der Meijden A., Boers S. A., Kreft D., ten Kate M. T., Falciani C., Pini A., Strandh M., Bakker-Woudenberg I. A. J. M., Hays J. P., Goessens W. H. F. |
| المساهمون: | van der Weide, H., Vermeulen-de Jongh, D. M. C., van der Meijden, A., Boers, S. A., Kreft, D., ten Kate, M. T., Falciani, C., Pini, A., Strandh, M., Bakker-Woudenberg, I. A. J. M., Hays, J. P., Goessens, W. H. F. |
| سنة النشر: | 2019 |
| المجموعة: | Università degli Studi di Siena: USiena air |
| مصطلحات موضوعية: | Antimicrobial activity, Antimicrobial peptide, Antimicrobial resistance, Colistin, Gram-negative bacteria, Klebsiella pneumoniae, Anti-Infective Agent, Antimicrobial Cationic Peptide, Drug Resistance, Bacterial, Genetic Variation, Genotype, Microbial Sensitivity Test, Microbial Viability |
| الوصف: | Colistin is an antimicrobial peptide (AMP) used as a drug of last resort, although plasmid-mediated colistin resistance (MCR) has been reported. AA139 and SET-M33 are novel AMPs currently in development for the treatment of multidrug-resistant (MDR) Gram-negative bacterial infections. As many AMPs have a similar mode of action to colistin, potentially leading to cross-resistance, the antimicrobial activity of AA139 and SET-M33 was investigated against a collection of 50 clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles, including colistin-resistant strains. The collection was genotypically characterised and susceptibility to clinically relevant antibiotics was determined. Susceptibility to AA139 and SET-M33 did not differ among the collection despite differences in underlying mechanisms of resistance or susceptibility to colistin. For three colistin-susceptible and three colistin-resistant strains with distinct MDR profiles as well as an additional MCR-producing strain, the bactericidal activity of AA139, SET-M33 and colistin during 24 h of exposure was examined. Following 24 h of exposure to AA139, SET-M33 or colistin, the seven strains were tested for changes in susceptibility to the respective AMPs. AA139 and SET-M33 showed a concentration-dependent bactericidal effect irrespective of bacterial susceptibility to colistin. Exposure to low colistin concentrations resulted in the development of colistin resistance in colistin-susceptible strains, whereas susceptibility to AA139 and SET-M33 following exposure to the respective AMPs was maintained. The two novel AMPs remained effective against colistin-resistant strains and may be promising novel drugs for the treatment of clinically and genotypically diverse MDR K. pneumoniae infections, including infections associated with colistin-resistant bacteria. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| ردمك: | 978-0-924857-91-1 0-924857-91-9 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31173867; info:eu-repo/semantics/altIdentifier/wos/WOS:000477928400008; volume:54; issue:2; firstpage:159; lastpage:166; numberofpages:8; journal:INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS; http://hdl.handle.net/11365/1105146Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85068449380; https://www.sciencedirect.com/science/article/pii/S0924857919301360Test |
| DOI: | 10.1016/j.ijantimicag.2019.05.019 |
| الإتاحة: | https://doi.org/10.1016/j.ijantimicag.2019.05.019Test http://hdl.handle.net/11365/1105146Test https://www.sciencedirect.com/science/article/pii/S0924857919301360Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E657D888 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780924857911 0924857919 |
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| DOI: | 10.1016/j.ijantimicag.2019.05.019 |