التفاصيل البيبلوغرافية
| العنوان: |
Insulin Detemir Provides Superior Glycaemic Control than Insulin NPH or Insulin Glargine in Type 1 Diabetic Subjects in a Clinical Setting. |
| المؤلفون: |
Jendle, Johan H., Norberg, Bengt |
| المصدر: |
Diabetes. Jun2007 Supplement 1, Vol. 56, pA548-A548. 1/5p. |
| مصطلحات موضوعية: |
*INSULIN, *TREATMENT of diabetes, *PEOPLE with diabetes, *BLOOD sugar, *DRUG dosage |
| مستخلص: |
Results: The advantages of basal insulin analogues for the treatment of diabetes are being questioned. The present analysis sought to determine whether in a clinical setting an improvement of diabetes control could be achieved when switching patients with type 1 diabetes on a basal-bolus regimen from insulin NPH or insulin glargine to basal insulin treatment with insulin detemir and continuing on short acting insulin. Subjects with type 1 diabetes (n=102) inadequately controlled by a basal-bolus regimen with short acting insulin analogues (insulin aspart or lyspro) in combination with a basal insulin where treated with insulin detemir in combination with the previous short acting insulin treatment. Insulin detemir was given sc OD or BID. 58 males and 44 females were followed during up to 18 months. Baseline data; 44±7 years body weight of 77±15 kg with a BMI25.3±3.9 kg/m². The diabetes duration was 20-±8 years. Baseline HbA1c was reduced from 7.9± 1.6% to 7.5±1.3%, p=0.0014. The total daily insulin dose was reduced from 51.8±18.4 U/d to 49.8±17.6 U/d, p=0.015. Also the basal insulin dose could be reduced from 27.9±1.8 U/d to 26.1 ±10.9 U/d, p=0.004. However, the average bolus dose was unchanged during the study. Neither weight gain, nor any significant change in BMI was observed during the study period. No serious hypoglycaemic episodes were registered. In conclusion a beneficial effect on the glycaemic control and a reduction of the insulin doses without any weight gain is seen when changing subjects with type 1 diabetes inadequately controlled on basal-bolus treatment to insulin detemir in combination with a short acting insulin analogue. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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