المؤلفون: Sebastián-Pérez, Víctor, García-Rubia, Alfonso, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., William, Samia, Blundell, Tom L., Maes, Louis, Martínez, Ana, Campillo, Nuria E., Botros, Sanaa S., Gil, Carmen

المساهمون: European Commission, Ministerio de Educación, Cultura y Deporte (España), Sebastián-Pérez, Víctor, García-Rubia, Alfonso, Seif el-Din, Sayed H., El-Lakkany, Naglaa M., William, Samia, Maes, Louis /, Martínez, Ana, Campillo, Nuria E., Gil, Carmen

مصطلحات موضوعية: Drug discovery, Quinazoline, Schistosoma mansoni, Target deconvolution

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/EC/FP7/602666; Publisher's version; https://doi.org/10.1080/14756366.2020.1712595Test; Sí; J Enzyme Inhib Med Chem 35(1):511-523 (2020); http://hdl.handle.net/10261/200761Test; http://dx.doi.org/10.13039/501100000780Test; http://dx.doi.org/10.13039/501100003176Test

الإتاحة: https://doi.org/10.1080/14756366.2020.1712595Test
https://doi.org/10.13039/501100000780Test
https://doi.org/10.13039/501100003176Test
http://hdl.handle.net/10261/200761Test

المؤلفون: Sebastian-Perez, Victor, García-Rubia, Alfonso, Seif El-Din, Sayed H, Sabra, Abdel-Nasser A, El-Lakkany, Naglaa M, William, Samia, Blundell, Tom L, Maes, Louis, Martinez, Ana, Campillo, Nuria E, Botros, Sanaa S, Gil, Carmen

مصطلحات موضوعية: Anthelmintics, Male, Models, Molecular, Dose-Response Relationship, Drug, Molecular Structure, Drug discovery, Schistosoma mansoni, 3. Good health, Mice, Structure-Activity Relationship, Aldehyde Reductase, parasitic diseases, target deconvolution, Quinazolines, Animals, Enzyme Inhibitors, quinazoline

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::33228151f15f827b914b7d156efe1a30Test

المؤلفون: Víctor Sebastián-Pérez, Ana Martínez, Nuria E. Campillo, Sanaa S. Botros, Alfonso García-Rubia, Samia William, Louis Maes, Tom L. Blundell, Sayed H. Seif el-Din, Abdel-Nasser A. Sabra, Carmen Gil, Naglaa M. El-Lakkany

المساهمون: Sebastian-Perez, Victor [0000-0002-8248-4496], Martinez, Ana [0000-0002-2707-8110], Campillo, Nuria E [0000-0002-9948-2665], Gil, Carmen [0000-0002-3882-6081], Apollo - University of Cambridge Repository, European Commission, Ministerio de Educación, Cultura y Deporte (España), Sebastián-Pérez, Víctor [0000-0002-8248-4496], García-Rubia, Alfonso [0000-0003-4002-910X], Seif el-Din, Sayed H. [0000-0002-0357-3467], El-Lakkany, Naglaa M. [0000-0002-5783-9945], William, Samia [0000-0002-0521-1734], Maes, Louis [/0000-0002-2324-9509], Martínez, Ana [0000-0002-2707-8110], Campillo, Nuria E. [0000-0002-9948-2665], Sebastián-Pérez, Víctor, García-Rubia, Alfonso, Seif el-Din, Sayed H., El-Lakkany, Naglaa M., William, Samia, Maes, Louis, Martínez, Ana, Campillo, Nuria E., Gil, Carmen

المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 511-523 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of enzyme inhibition and medicinal chemistry
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Male, Models, Molecular, Scaffold, 01 natural sciences, Mice, chemistry.chemical_compound, Drug Discovery, Quinazoline, Enzyme Inhibitors, Target deconvolution, Anthelmintics, chemistry.chemical_classification, Molecular Structure, biology, Drug discovery, Pharmacology. Therapy, Schistosoma mansoni, General Medicine, 3. Good health, Praziquantel, Chemistry, Biochemistry, Research Article, Research Paper, quinazoline, medicine.drug, Phenotypic screening, RM1-950, Structure-Activity Relationship, Aldehyde Reductase, parasitic diseases, medicine, Animals, Biology, Pharmacology, Aldose reductase, Dose-Response Relationship, Drug, 010405 organic chemistry, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, target deconvolution, Quinazolines, Human medicine, Therapeutics. Pharmacology

وصف الملف: application/pdf; pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355a1a8e5ea3d14c01902878c40287e5Test
https://doi.org/10.1080/14756366.2020.1712595Test

المؤلفون: Irene G. Salado, Naglaa M. El-Lakkany, Maarten Sijm, Sayed H. Seif el-Din, Carmen Gil, Abdel-Nasser A. Sabra, Erik de Heuvel, Harry P. de Koning, A.R. Blaazer, Jane C. Munday, Yang Zheng, Alfonso García-Rubia, Louis Maes, Sanaa S. Botros, Iwan J. P. de Esch, Samia William, Geert Jan Sterk, Rob Leurs, Koen Augustyns, Víctor Sebastián-Pérez

المساهمون: European Commission, Ministerio de Educación, Cultura y Deporte (España), China Scholarship Council, El-Lakkany, Naglaa M. [0000-0002-5783-9945], Seif el-Din, Sayed H. [0000-0002-0357-3467], García-Rubia, Alfonso [0000-0003-4002-910X], Sebastián-Pérez, Víctor [0000-0002-8248-4496], Blaazer, Antoni R. [0000-0003-2329-0760], Munday, Jane C. [0000-0001-7792-2749], Maes, Louis [0000-0002-2324-9509], Leurs, Rob [0000-0003-1354-2848], Gil, Carmen [0000-0002-3882-6081], Koning, Harry de [0000-0002-9963-1827], El-Lakkany, Naglaa M., Seif el-Din, Sayed H., García-Rubia, Alfonso, Sebastián-Pérez, Víctor, Blaazer, Antoni R., Munday, Jane C., Maes, Louis, Leurs, Rob, Gil, Carmen, Koning, Harry de, Physical Chemistry, AIMMS, Medicinal chemistry, Chemistry and Pharmaceutical Sciences

المصدر: International Journal for Parasitology: Drugs and Drug Resistance
Digital.CSIC. Repositorio Institucional del CSIC
instname
Botros, S S, William, S, Sabra, A N A, El-Lakkany, N M, Seif el-Din, S H, García-Rubia, A, Sebastián-Pérez, V, Blaazer, A R, de Heuvel, E, Sijm, M, Zheng, Y, Salado, I G, Munday, J C, Maes, L, de Esch, I J P, Sterk, G J, Augustyns, K, Leurs, R, Gil, C & De Koning, H P 2019, ' Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity ', International Journal for Parasitology: Drugs and Drug Resistance, vol. 9, pp. 35-43 . https://doi.org/10.1016/j.ijpddr.2019.01.001Test
International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss, Pp 35-43 (2019)
International Journal for Parasitology: Drugs and Drug Resistance, 9, 35-43. Elsevier

مصطلحات موضوعية: Male, 0301 basic medicine, Egg load, Worm killing, 030231 tropical medicine, Schistosomiasis, Article, Praziquantel, lcsh:Infectious and parasitic diseases, Mouse model, Small Molecule Libraries, Andrology, Mice, 03 medical and health sciences, In vitro drug screening, 0302 clinical medicine, In vivo, Drug Discovery, parasitic diseases, medicine, Animals, Humans, lcsh:RC109-216, Phosphodiesterase, Pharmacology (medical), Parasite Egg Count, Anthelmintics, Pharmacology, biology, Pharmacology. Therapy, fungi, Imidazoles, Schistosoma mansoni, Fibroblasts, biology.organism_classification, medicine.disease, In vitro, High-Throughput Screening Assays, 3. Good health, 030104 developmental biology, Infectious Diseases, 3',5'-Cyclic-AMP Phosphodiesterases, Parasitology, Human medicine, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c92e19004a518cecbe3412299fb621Test
https://doi.org/10.1016/j.ijpddr.2019.01.001Test

المؤلفون: Botros, Sanaa S.¹ (AUTHOR), El-Lakkany, Naglaa M.¹ (AUTHOR), Seif el-Din, Sayed H.¹ (AUTHOR), William, Samia² (AUTHOR), Sabra, Abdel-Nasser¹ (AUTHOR), Hammam, Olfat A.³ (AUTHOR), de Koning, Harry P.^1,4 (AUTHOR) Harry.de-Koning@glasgow.ac.uk

المصدر: Experimental Parasitology. Jan2020, Vol. 208, pN.PAG-N.PAG. 1p.

مصطلحات موضوعية: *SCHISTOSOMA mansoni, *CYCLIC nucleotide phosphodiesterases, *PHOSPHODIESTERASES